Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules

Purpose: To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature. Materials and methods: Mesenteric microvessels of rats were examined after an intravenous injection of fluorocein-labeled erythrocytes or...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of cardiology Vol. 98; no. 2; pp. 245 - 252
Main Authors:	Yasu, Takanori, Greener, Yigal, Jablonski, Edward, Killam, Anne L., Fukuda, Shunichi, Suematsu, Makoto, Tojo, Shinichiro J., Schmid-Schönbein, Geert W.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 15-02-2005 Elsevier Science
Subjects:	Animals Biological and medical sciences Blood Pressure Cardiology. Vascular system Contrast Echocardiography Endothelial Cells - physiology Erythrocytes Fluorocarbons Heart Rate Inflammation - diagnostic imaging Inflammation - physiopathology Kinetics Leukocyte Leukocytes - physiology Male Medical sciences Membrane adhesion Microcirculation Microcirculation - physiology Microscopy, Fluorescence Microspheres Platelet Activating Factor Rats Rats, Wistar Ultrasonography Venules - cytology Venules - pathology Membrane adhesion Microcirculation Echocardiography Leukocyte Contrast Sonography Endothelial cell Microsphere Cardiovascular disease Retention Venule Adhesion Membrane Ultrasound
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Purpose: To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature. Materials and methods: Mesenteric microvessels of rats were examined after an intravenous injection of fluorocein-labeled erythrocytes or PFP microspheres by fluorescence intravital microscopy with and without local application of 10 −8 M platelet activating factor (PAF) as an experimental form of inflammation. Results: All the microspheres passed freely through arterioles and capillaries. Mean velocities of the microspheres in each vessel were closely correlated with those of erythrocytes. Only a minor fraction of the microspheres was retained in the venules (≥0.1 s stoppage) by attachment to endothelial cells. The frequency of microsphere retention in venules was significantly enhanced by PAF (2.6±2.1%, P<0.01 vs. control), especially in regions with leukocyte adhesion. Treatment with a monoclonal antibody to intercellular adhesion molecule-1, P-selectin or the common leukocyte antigen inhibited PAF-induced microsphere retention in venules ( P<0.05). In the inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. Conclusion: In inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. These results suggest that ultrasonography with microspheres has the potential to evaluate inflammatory site distribution as well as tissue perfusion.
AbstractList	Purpose: To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature. Materials and methods: Mesenteric microvessels of rats were examined after an intravenous injection of fluorocein-labeled erythrocytes or PFP microspheres by fluorescence intravital microscopy with and without local application of 10-8 M platelet activating factor (PAF) as an experimental form of inflammation. Results: All the microspheres passed freely through arterioles and capillaries. Mean velocities of the microspheres in each vessel were closely correlated with those of erythrocytes. Only a minor fraction of the microspheres was retained in the venules (>=0.1 s stoppage) by attachment to endothelial cells. The frequency of microsphere retention in venules was significantly enhanced by PAF (2.6±2.1%, P<0.01 vs. control), especially in regions with leukocyte adhesion. Treatment with a monoclonal antibody to intercellular adhesion molecule-1, P-selectin or the common leukocyte antigen inhibited PAF-induced microsphere retention in venules (P<0.05). In the inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. Conclusion: In inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. These results suggest that ultrasonography with microspheres has the potential to evaluate inflammatory site distribution as well as tissue perfusion. To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature. Mesenteric microvessels of rats were examined after an intravenous injection of fluorocein-labeled erythrocytes or PFP microspheres by fluorescence intravital microscopy with and without local application of 10(-8) M platelet activating factor (PAF) as an experimental form of inflammation. All the microspheres passed freely through arterioles and capillaries. Mean velocities of the microspheres in each vessel were closely correlated with those of erythrocytes. Only a minor fraction of the microspheres was retained in the venules (> or =0.1 s stoppage) by attachment to endothelial cells. The frequency of microsphere retention in venules was significantly enhanced by PAF (2.6+/-2.1%, P<0.01 vs. control), especially in regions with leukocyte adhesion. Treatment with a monoclonal antibody to intercellular adhesion molecule-1, P-selectin or the common leukocyte antigen inhibited PAF-induced microsphere retention in venules (P<0.05). In the inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. In inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. These results suggest that ultrasonography with microspheres has the potential to evaluate inflammatory site distribution as well as tissue perfusion. Purpose: To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature. Materials and methods: Mesenteric microvessels of rats were examined after an intravenous injection of fluorocein-labeled erythrocytes or PFP microspheres by fluorescence intravital microscopy with and without local application of 10 −8 M platelet activating factor (PAF) as an experimental form of inflammation. Results: All the microspheres passed freely through arterioles and capillaries. Mean velocities of the microspheres in each vessel were closely correlated with those of erythrocytes. Only a minor fraction of the microspheres was retained in the venules (≥0.1 s stoppage) by attachment to endothelial cells. The frequency of microsphere retention in venules was significantly enhanced by PAF (2.6±2.1%, P<0.01 vs. control), especially in regions with leukocyte adhesion. Treatment with a monoclonal antibody to intercellular adhesion molecule-1, P-selectin or the common leukocyte antigen inhibited PAF-induced microsphere retention in venules ( P<0.05). In the inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. Conclusion: In inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. These results suggest that ultrasonography with microspheres has the potential to evaluate inflammatory site distribution as well as tissue perfusion. PURPOSETo characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature.MATERIALS AND METHODSMesenteric microvessels of rats were examined after an intravenous injection of fluorocein-labeled erythrocytes or PFP microspheres by fluorescence intravital microscopy with and without local application of 10(-8) M platelet activating factor (PAF) as an experimental form of inflammation.RESULTSAll the microspheres passed freely through arterioles and capillaries. Mean velocities of the microspheres in each vessel were closely correlated with those of erythrocytes. Only a minor fraction of the microspheres was retained in the venules (> or =0.1 s stoppage) by attachment to endothelial cells. The frequency of microsphere retention in venules was significantly enhanced by PAF (2.6+/-2.1%, P<0.01 vs. control), especially in regions with leukocyte adhesion. Treatment with a monoclonal antibody to intercellular adhesion molecule-1, P-selectin or the common leukocyte antigen inhibited PAF-induced microsphere retention in venules (P<0.05). In the inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules.CONCLUSIONIn inflamed microcirculation, a small subgroup of microspheres becomes attached to venular endothelial cells in regions with leukocyte adhesion via interaction among microspheres, activated leukocytes and endothelial cells via adhesion molecules. These results suggest that ultrasonography with microspheres has the potential to evaluate inflammatory site distribution as well as tissue perfusion.
Author	Killam, Anne L. Jablonski, Edward Yasu, Takanori Fukuda, Shunichi Tojo, Shinichiro J. Greener, Yigal Suematsu, Makoto Schmid-Schönbein, Geert W.
Author_xml	– sequence: 1 givenname: Takanori surname: Yasu fullname: Yasu, Takanori email: tyasu@omiya.jichi.ac.jp organization: Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA – sequence: 2 givenname: Yigal surname: Greener fullname: Greener, Yigal organization: Molecular Biosystems Inc., San Diego, CA 92121-2789, USA – sequence: 3 givenname: Edward surname: Jablonski fullname: Jablonski, Edward organization: Molecular Biosystems Inc., San Diego, CA 92121-2789, USA – sequence: 4 givenname: Anne L. surname: Killam fullname: Killam, Anne L. organization: Molecular Biosystems Inc., San Diego, CA 92121-2789, USA – sequence: 5 givenname: Shunichi surname: Fukuda fullname: Fukuda, Shunichi organization: Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA – sequence: 6 givenname: Makoto surname: Suematsu fullname: Suematsu, Makoto organization: Department of Biochemistry, Keio University, Tokyo, Japan – sequence: 7 givenname: Shinichiro J. surname: Tojo fullname: Tojo, Shinichiro J. organization: Sumitomo Pharmaceutical Co. Ltd., Osaka, Japan – sequence: 8 givenname: Geert W. surname: Schmid-Schönbein fullname: Schmid-Schönbein, Geert W. organization: Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16474691$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15686774$$D View this record in MEDLINE/PubMed
BookMark	eNqFkc2KFDEUhYOMOD2jbyCSje6qzV9VKhthGPyDATe6DqnUjZ02nbRJqmHewkc2RTfMTiGQcPjuyb333KCrmCIg9JqSLSV0eL_f-r01ed4yQniTtkSwZ2hDRyk6KntxhTYNk13PJL9GN6XsCSFCqfEFuqb9MA5Sig36c2erP5kKMw6w_Er2sULBJs4Y4pzqDoI3AVsIoTRlZ6IFnKFCrD5FnBxeQs2mpKVV2BTXd8UHb3Mqxx3k5rWqxkcff-IjZBeWlNOxHRMB-9iOC-bQvj9BXAKUl-i5M6HAq8t9i358-vj9_kv38O3z1_u7h84KRmtnJ8KFAeMcNyOXalLcKj7RuReUUQKTGmGylE5s5FQNpLeMWmYsc5LNjvf8Fr07-7Zefi9Qqj74ss7Z-kpL0YMUhPRE_RekSgyDHFdHcQbX4UsGp4_ZH0x-1JToNTK91-fI9BrZqrbIWtmbi_8ytT08FV0yasDbC2CKNcHlFoIvT9wgpBgUbdyHMwdtbScPWRfroQU2-wy26jn5f3fyF11kvL4
CODEN	IJCDD5
CitedBy_id	crossref_primary_10_1002_bit_20625 crossref_primary_10_1111_j_1549_8719_2011_00152_x crossref_primary_10_1021_acs_chemrev_4c00009 crossref_primary_10_7863_jum_2006_25_7_883 crossref_primary_10_1016_j_ultrasmedbio_2018_06_018 crossref_primary_10_1146_annurev_bioeng_8_061505_095708 crossref_primary_10_1016_j_pbiomolbio_2006_07_017 crossref_primary_10_1253_circj_69_1041 crossref_primary_10_1016_j_amjsurg_2011_10_024 crossref_primary_10_3390_diagnostics13050855
Cites_doi	10.1016/S0021-9258(18)38167-5 10.1161/01.RES.65.2.458 10.1016/S0735-1097(98)00311-8 10.1253/circj.67.630 10.1016/S0301-5629(02)00532-X 10.1016/S0735-1097(96)00328-2 10.1182/blood.V74.6.2172.2172 10.1161/01.RES.85.8.663 10.1016/S0735-1097(97)00197-6 10.1161/01.CIR.101.6.668 10.1161/01.CIR.94.12.3334 10.1038/359848a0 10.1161/01.CIR.93.10.1784 10.1172/JCI116501 10.1161/01.CIR.92.9.2391 10.1016/S0735-1097(99)00209-0 10.1093/oxfordjournals.jbchem.a122857 10.1016/0026-2862(80)90083-7 10.1161/01.CIR.98.20.2187 10.1038/340167a0 10.1164/ajrccm.157.2.9704102 10.1016/0735-1097(90)90565-7 10.1161/01.CIR.98.1.1 10.1016/S0735-1097(97)00029-6 10.1002/eji.1830150211 10.1161/01.CIR.98.4.290
ContentType	Journal Article
Copyright	2004 Elsevier Ireland Ltd 2005 INIST-CNRS
Copyright_xml	– notice: 2004 Elsevier Ireland Ltd – notice: 2005 INIST-CNRS
DBID	IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 7T5 8FD FR3 H94 P64 7X8
DOI	10.1016/j.ijcard.2003.10.042
DatabaseName	Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Biotechnology Research Abstracts Immunology Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitleList	AIDS and Cancer Research Abstracts MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1874-1754
EndPage	252
ExternalDocumentID	10_1016_j_ijcard_2003_10_042 15686774 16474691 S0167527304000609
Genre	Journal Article
GroupedDBID	--- --K --M .1- .55 .FO .GJ .~1 0R~ 0SF 1B1 1P~ 1RT 1~. 1~5 29J 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABFNM ABJNI ABLJU ABLVK ABMAC ABMZM ABOCM ABXDB ABYKQ ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEB HMK HMO HVGLF HZ~ IHE J1W KOM LCYCR M29 M41 MO0 N9A NCXOZ O-L O9- OA. OAUVE OL~ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SEL SES SEW SPCBC SSH SSZ T5K UV1 WUQ X7M Z5R ZA5 ZGI ~G- AAUGY ABPIF ABPTK IQODW AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX ADVLN AFJKZ CITATION 7QO 7T5 8FD FR3 H94 P64 7X8
ID	FETCH-LOGICAL-c421t-cb034aeaff3a8379b93c93b1d541210eb98ebc11b28319605c21c2ac2f72df353
ISSN	0167-5273
IngestDate	Fri Oct 25 22:59:04 EDT 2024 Fri Oct 25 21:46:21 EDT 2024 Thu Sep 26 16:21:54 EDT 2024 Sat Sep 28 07:51:33 EDT 2024 Sun Oct 22 16:09:02 EDT 2023 Fri Feb 23 02:26:46 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	Membrane adhesion Microcirculation Echocardiography Leukocyte Contrast Sonography Endothelial cell Microsphere Cardiovascular disease Retention Venule Adhesion Membrane Ultrasound
Language	English
License	CC BY 4.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c421t-cb034aeaff3a8379b93c93b1d541210eb98ebc11b28319605c21c2ac2f72df353
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	15686774
PQID	19466785
PQPubID	23462
PageCount	8
ParticipantIDs	proquest_miscellaneous_67400509 proquest_miscellaneous_19466785 crossref_primary_10_1016_j_ijcard_2003_10_042 pubmed_primary_15686774 pascalfrancis_primary_16474691 elsevier_sciencedirect_doi_10_1016_j_ijcard_2003_10_042
PublicationCentury	2000
PublicationDate	2005-02-15
PublicationDateYYYYMMDD	2005-02-15
PublicationDate_xml	– month: 02 year: 2005 text: 2005-02-15 day: 15
PublicationDecade	2000
PublicationPlace	Shannon
PublicationPlace_xml	– name: Shannon – name: Netherlands
PublicationTitle	International journal of cardiology
PublicationTitleAlternate	Int J Cardiol
PublicationYear	2005
Publisher	Elsevier Ireland Ltd Elsevier Science
Publisher_xml	– name: Elsevier Ireland Ltd – name: Elsevier Science
References	Kubes, Ibbotson, Russell, Wallace, Granger (BIB7) 1990; 259 Shreiden, Cole, Ramage (BIB11) 1996; 93 Skyba, Camarano, Goodman, Price, Skalak, Kaul (BIB2) 1996; 28 Lindner, Coggins, Kaul, Klibanov, Brandenburger, Ley (BIB6) 2000; 101 Engler, Schmid-Schönbein, Pavelec (BIB8) 1983; 111 Nishio, Suzuki, Aoki, Suzuki, Miyake, Sato (BIB18) 1998; 157 Keller, Spotnitz, Matthew, Glasheen, Watson, Kaul (BIB4) 1990; 16 Schmid-Schönbein, Murakami (BIB15) 1985; 4 Villanueva, Jankowski, Klinbanov, Pina, Alber, Watkins (BIB34) 1998; 98 Cohen, Cheirif, Segar, Gillam, Gottdiener, Hausnerova (BIB1) 1998; 32 Kobayashi, Yasu, Yamada, Kudo, Kuroki, Miyatake (BIB32) 2003; 63 Slezak, Horan (BIB14) 1989; 74 Skyba, Price, Linka, Skalak, Kaul (BIB30) 1998; 98 Precott, Zimmerman, McIntyre (BIB12) 1990; 265 Iigo, Suematsu, Higashida, Oheda, Matsumoto, Wakabayashi (BIB25) 1997; 273 Weyrich, Ma, Lefer, Albertine, Lefer (BIB27) 1993; 91 Lindner, Ismail, Spotniz, Skyba, Jayaweera, Kaul (BIB5) 1998; 98 Kobayashi, Yasu, Yamada, Kudo, Kawakami, Kuroki (BIB31) 2002; 28 Shreiden, Cole, Ramage (BIB9) 1996; 93 Harris, Consta, Delano, Zweifach, Schmid-Schönbein (BIB17) 1998; 273 Villanueva, Jankowski, Manaugh, Wagner (BIB21) 1996; 30 Slezak, Horan (BIB13) 1989; 340 Suematsu, DeLano, Poole, Engler, Miyasaka, Zweifach (BIB10) 1994; 70 Keller, Segal, Kaul, Duling (BIB20) 1989; 65 Woollett, Barclay, Puklavec, Williams (BIB16) 1985; 15 Porter, Xie (BIB28) 1995; 92 Wei, Skyba, Firschke, Jayaweera, Lindner, Kaul (BIB29) 1997; 29 Lanza, Wallance, Scott, Cacheris, Abenschein, Christy (BIB33) 1996; 94 Schmid-Schönbein, Usami, Skalak, Chien (BIB24) 1980; 19 Palabrica, Lobb, Furie (BIB26) 1992; 359 Hayashi, Takamiya, Yamaguchi, Matsumoto, Tojo, Tamatani (BIB19) 1999; 85 Yasu, Schmid-Schönbein, Cotter, DeMaria (BIB3) 1999; 34 Suematsu, Kurose, Asako, Miura, Tsuchiya (BIB23) 1989; 106 Clay, Wagner, Golec, Villanueva (BIB22) 1999; 33 Kobayashi (10.1016/j.ijcard.2003.10.042_BIB31) 2002; 28 Kobayashi (10.1016/j.ijcard.2003.10.042_BIB32) 2003; 63 Harris (10.1016/j.ijcard.2003.10.042_BIB17) 1998; 273 Skyba (10.1016/j.ijcard.2003.10.042_BIB2) 1996; 28 Suematsu (10.1016/j.ijcard.2003.10.042_BIB23) 1989; 106 Iigo (10.1016/j.ijcard.2003.10.042_BIB25) 1997; 273 Keller (10.1016/j.ijcard.2003.10.042_BIB4) 1990; 16 Slezak (10.1016/j.ijcard.2003.10.042_BIB14) 1989; 74 Lindner (10.1016/j.ijcard.2003.10.042_BIB6) 2000; 101 Clay (10.1016/j.ijcard.2003.10.042_BIB22) 1999; 33 Suematsu (10.1016/j.ijcard.2003.10.042_BIB10) 1994; 70 Palabrica (10.1016/j.ijcard.2003.10.042_BIB26) 1992; 359 Engler (10.1016/j.ijcard.2003.10.042_BIB8) 1983; 111 Porter (10.1016/j.ijcard.2003.10.042_BIB28) 1995; 92 Keller (10.1016/j.ijcard.2003.10.042_BIB20) 1989; 65 Kubes (10.1016/j.ijcard.2003.10.042_BIB7) 1990; 259 Slezak (10.1016/j.ijcard.2003.10.042_BIB13) 1989; 340 Woollett (10.1016/j.ijcard.2003.10.042_BIB16) 1985; 15 Villanueva (10.1016/j.ijcard.2003.10.042_BIB21) 1996; 30 Schmid-Schönbein (10.1016/j.ijcard.2003.10.042_BIB24) 1980; 19 Lanza (10.1016/j.ijcard.2003.10.042_BIB33) 1996; 94 Nishio (10.1016/j.ijcard.2003.10.042_BIB18) 1998; 157 Villanueva (10.1016/j.ijcard.2003.10.042_BIB34) 1998; 98 Cohen (10.1016/j.ijcard.2003.10.042_BIB1) 1998; 32 Precott (10.1016/j.ijcard.2003.10.042_BIB12) 1990; 265 Shreiden (10.1016/j.ijcard.2003.10.042_BIB11) 1996; 93 Skyba (10.1016/j.ijcard.2003.10.042_BIB30) 1998; 98 Schmid-Schönbein (10.1016/j.ijcard.2003.10.042_BIB15) 1985; 4 Weyrich (10.1016/j.ijcard.2003.10.042_BIB27) 1993; 91 Shreiden (10.1016/j.ijcard.2003.10.042_BIB9) 1996; 93 Hayashi (10.1016/j.ijcard.2003.10.042_BIB19) 1999; 85 Wei (10.1016/j.ijcard.2003.10.042_BIB29) 1997; 29 Lindner (10.1016/j.ijcard.2003.10.042_BIB5) 1998; 98 Yasu (10.1016/j.ijcard.2003.10.042_BIB3) 1999; 34
References_xml	– volume: 92 start-page: 2391 year: 1995 end-page: 2395 ident: BIB28 article-title: Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles: demonstration and potential mechanisms publication-title: Circulation contributor: fullname: Xie – volume: 4 start-page: 311 year: 1985 end-page: 328 ident: BIB15 article-title: Blood flow in contracting arterioles publication-title: Int. J. Microcirc. Clin. Exp. contributor: fullname: Murakami – volume: 74 start-page: 2172 year: 1989 end-page: 2177 ident: BIB14 article-title: Fluorescent in vivo tracking of hematopoietic cells: Part I. Technical considerations publication-title: Blood contributor: fullname: Horan – volume: 93 start-page: 1784 year: 1996 end-page: 1787 ident: BIB9 article-title: Leukocyte adhesion to the coronary microvasculature during ischemia and reperfusion in an in vivo canine model publication-title: Circulation contributor: fullname: Ramage – volume: 28 start-page: 949 year: 2002 end-page: 956 ident: BIB31 article-title: Endothelial cell injury in venule and capillary induced by contrast ultrasonography publication-title: Ultrasound Med. Biol. contributor: fullname: Kuroki – volume: 28 start-page: 1292 year: 1996 end-page: 1300 ident: BIB2 article-title: Hemodynamic characteristics, myocardial kinetics and microvascular rheology of FS-069, a second-generation echocardiographic contrast agent capable of producing myocardial opacification from a venous injection publication-title: J. Am. Coll. Cardiol. contributor: fullname: Kaul – volume: 32 start-page: 746 year: 1998 end-page: 752 ident: BIB1 article-title: Improved left ventricular endocardial border delineation and opacification with OPTISON (FS069), a new echocardiographic contrast agent; results of a phase III multicenter trial publication-title: J. Am. Coll. Cardiol. contributor: fullname: Hausnerova – volume: 85 start-page: 663 year: 1999 end-page: 671 ident: BIB19 article-title: Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme publication-title: Circ. Res. contributor: fullname: Tamatani – volume: 91 start-page: 2620 year: 1993 end-page: 2629 ident: BIB27 article-title: In vivo neutralization of P-selectin protests ferine heart and endothelium in myocardial ischemia and reperfusion injury publication-title: J. Clin. Invest. contributor: fullname: Lefer – volume: 98 start-page: 2187 year: 1998 end-page: 2194 ident: BIB5 article-title: Albumin microbubble persistance during myocardial contrast echocardiography is associated with microvascular endothelial glycocalyx damage publication-title: Circulation contributor: fullname: Kaul – volume: 273 start-page: H138 year: 1997 end-page: H147 ident: BIB25 article-title: Constitutive expression of ICAM-1 in rat microvascular system analyzed by laser confocal microscopy publication-title: Am. J. Physiol. contributor: fullname: Wakabayashi – volume: 273 start-page: H1005 year: 1998 end-page: H1015 ident: BIB17 article-title: Mechanism of cell injury in rat mesentary and cremaster muscle publication-title: Am. J. Physiol. contributor: fullname: Schmid-Schönbein – volume: 259 start-page: G300 year: 1990 end-page: G305 ident: BIB7 article-title: Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence publication-title: Am. J. Physiol. contributor: fullname: Granger – volume: 70 start-page: 684 year: 1994 end-page: 695 ident: BIB10 article-title: Spatial and temporal correlation between leukocyte behavior and cell injury postischemic rat skeletal muscle microcirculation publication-title: Lab. Invest. contributor: fullname: Zweifach – volume: 359 start-page: 848 year: 1992 end-page: 851 ident: BIB26 article-title: Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets publication-title: Nature contributor: fullname: Furie – volume: 16 start-page: 1267 year: 1990 end-page: 1279 ident: BIB4 article-title: Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography: an experimental evaluation publication-title: J. Am. Coll. Cardiol. contributor: fullname: Kaul – volume: 111 start-page: 98 year: 1983 end-page: 111 ident: BIB8 article-title: Leukocyte capillary plugging in myocardial ischemia and reperfusion in dogs publication-title: Am. J. Pathol. contributor: fullname: Pavelec – volume: 30 start-page: 689 year: 1996 end-page: 693 ident: BIB21 article-title: Albumin microbubble adherence to human coronary endothelium: implications for assessment of endothelial function using myocardial contrast echocardiography publication-title: J. Am. Coll. Cardiol. contributor: fullname: Wagner – volume: 15 start-page: 168 year: 1985 end-page: 173 ident: BIB16 article-title: Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes publication-title: Eur. J. Immunol. contributor: fullname: Williams – volume: 19 start-page: 45 year: 1980 end-page: 70 ident: BIB24 article-title: The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels publication-title: Microvasc. Res. contributor: fullname: Chien – volume: 93 start-page: 1784 year: 1996 end-page: 1787 ident: BIB11 article-title: Leukocyte adhesion to the coronary microvasculature during ischemia and reperfusion in an in vivo canine model publication-title: Circulation contributor: fullname: Ramage – volume: 33 start-page: 407A year: 1999 ident: BIB22 article-title: New insights into mechanisms of albumin microbubble adhesion to coronary endothelium with chemically modified microbubbles publication-title: J. Am. Coll. Cardiol. (suppl) contributor: fullname: Villanueva – volume: 34 start-page: 578 year: 1999 end-page: 586 ident: BIB3 article-title: Flow dynamics of QW7437, a new dodecafluoropentane ultrasound contrast agent, in the microcirculation: microvascular mechanisms for the persistent tissue echo-enhancement publication-title: J. Am. Coll. Cardiol. contributor: fullname: DeMaria – volume: 157 start-page: 599 year: 1998 end-page: 609 ident: BIB18 article-title: Differential contribution of various adhesion molecules to leukocyte kinetics in pulmonary microvessels of hyperoxia-exposed rat lungs publication-title: Am. J. Res. Crit. Care Med. contributor: fullname: Sato – volume: 106 start-page: 355 year: 1989 end-page: 360 ident: BIB23 article-title: In vivo visualization of oxyradical-dependent photoemission during endothelium–granulocyte interaction in microvascular beds treated with platelet-activating factor publication-title: J. Biochem. contributor: fullname: Tsuchiya – volume: 63 start-page: 630 year: 2003 end-page: 636 ident: BIB32 article-title: The influence of contrast ultrasonography with perflutren lipid microspheres on microvessels publication-title: Circ. J. contributor: fullname: Miyatake – volume: 65 start-page: 458 year: 1989 end-page: 467 ident: BIB20 article-title: The behavior of sonicated albumin microspheres within the microcirculation: a basis for their use during myocardial contrast echocardiography publication-title: Circ. Res. contributor: fullname: Duling – volume: 94 start-page: 3334 year: 1996 end-page: 3340 ident: BIB33 article-title: A novel site-targeted ultrasound contrast agent with broad biomedical application publication-title: Circulation contributor: fullname: Christy – volume: 98 start-page: 290 year: 1998 end-page: 293 ident: BIB30 article-title: Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue publication-title: Circulation contributor: fullname: Kaul – volume: 340 start-page: 167 year: 1989 end-page: 168 ident: BIB13 article-title: Stable cell membrane labelling publication-title: Nature contributor: fullname: Horan – volume: 98 start-page: 1 year: 1998 end-page: 5 ident: BIB34 article-title: Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells publication-title: Circulation contributor: fullname: Watkins – volume: 101 start-page: 668 year: 2000 end-page: 675 ident: BIB6 article-title: Microbubble persistance in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes publication-title: Circulation contributor: fullname: Ley – volume: 265 start-page: 17381 year: 1990 end-page: 17384 ident: BIB12 article-title: Platelet-activating factor publication-title: J. Biol. Chem. contributor: fullname: McIntyre – volume: 29 start-page: 1081 year: 1997 end-page: 1088 ident: BIB29 article-title: Interactions between microbubbles and ultrasound: in vitro and in vivo observations publication-title: J. Am. Coll. Cardiol. contributor: fullname: Kaul – volume: 265 start-page: 17381 year: 1990 ident: 10.1016/j.ijcard.2003.10.042_BIB12 article-title: Platelet-activating factor publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)38167-5 contributor: fullname: Precott – volume: 65 start-page: 458 year: 1989 ident: 10.1016/j.ijcard.2003.10.042_BIB20 article-title: The behavior of sonicated albumin microspheres within the microcirculation: a basis for their use during myocardial contrast echocardiography publication-title: Circ. Res. doi: 10.1161/01.RES.65.2.458 contributor: fullname: Keller – volume: 32 start-page: 746 year: 1998 ident: 10.1016/j.ijcard.2003.10.042_BIB1 article-title: Improved left ventricular endocardial border delineation and opacification with OPTISON (FS069), a new echocardiographic contrast agent; results of a phase III multicenter trial publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(98)00311-8 contributor: fullname: Cohen – volume: 63 start-page: 630 year: 2003 ident: 10.1016/j.ijcard.2003.10.042_BIB32 article-title: The influence of contrast ultrasonography with perflutren lipid microspheres on microvessels publication-title: Circ. J. doi: 10.1253/circj.67.630 contributor: fullname: Kobayashi – volume: 273 start-page: H138 year: 1997 ident: 10.1016/j.ijcard.2003.10.042_BIB25 article-title: Constitutive expression of ICAM-1 in rat microvascular system analyzed by laser confocal microscopy publication-title: Am. J. Physiol. contributor: fullname: Iigo – volume: 28 start-page: 949 year: 2002 ident: 10.1016/j.ijcard.2003.10.042_BIB31 article-title: Endothelial cell injury in venule and capillary induced by contrast ultrasonography publication-title: Ultrasound Med. Biol. doi: 10.1016/S0301-5629(02)00532-X contributor: fullname: Kobayashi – volume: 28 start-page: 1292 year: 1996 ident: 10.1016/j.ijcard.2003.10.042_BIB2 article-title: Hemodynamic characteristics, myocardial kinetics and microvascular rheology of FS-069, a second-generation echocardiographic contrast agent capable of producing myocardial opacification from a venous injection publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(96)00328-2 contributor: fullname: Skyba – volume: 74 start-page: 2172 year: 1989 ident: 10.1016/j.ijcard.2003.10.042_BIB14 article-title: Fluorescent in vivo tracking of hematopoietic cells: Part I. Technical considerations publication-title: Blood doi: 10.1182/blood.V74.6.2172.2172 contributor: fullname: Slezak – volume: 85 start-page: 663 year: 1999 ident: 10.1016/j.ijcard.2003.10.042_BIB19 article-title: Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme publication-title: Circ. Res. doi: 10.1161/01.RES.85.8.663 contributor: fullname: Hayashi – volume: 30 start-page: 689 year: 1996 ident: 10.1016/j.ijcard.2003.10.042_BIB21 article-title: Albumin microbubble adherence to human coronary endothelium: implications for assessment of endothelial function using myocardial contrast echocardiography publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(97)00197-6 contributor: fullname: Villanueva – volume: 273 start-page: H1005 year: 1998 ident: 10.1016/j.ijcard.2003.10.042_BIB17 article-title: Mechanism of cell injury in rat mesentary and cremaster muscle publication-title: Am. J. Physiol. contributor: fullname: Harris – volume: 101 start-page: 668 year: 2000 ident: 10.1016/j.ijcard.2003.10.042_BIB6 article-title: Microbubble persistance in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes publication-title: Circulation doi: 10.1161/01.CIR.101.6.668 contributor: fullname: Lindner – volume: 70 start-page: 684 year: 1994 ident: 10.1016/j.ijcard.2003.10.042_BIB10 article-title: Spatial and temporal correlation between leukocyte behavior and cell injury postischemic rat skeletal muscle microcirculation publication-title: Lab. Invest. contributor: fullname: Suematsu – volume: 111 start-page: 98 year: 1983 ident: 10.1016/j.ijcard.2003.10.042_BIB8 article-title: Leukocyte capillary plugging in myocardial ischemia and reperfusion in dogs publication-title: Am. J. Pathol. contributor: fullname: Engler – volume: 94 start-page: 3334 year: 1996 ident: 10.1016/j.ijcard.2003.10.042_BIB33 article-title: A novel site-targeted ultrasound contrast agent with broad biomedical application publication-title: Circulation doi: 10.1161/01.CIR.94.12.3334 contributor: fullname: Lanza – volume: 359 start-page: 848 year: 1992 ident: 10.1016/j.ijcard.2003.10.042_BIB26 article-title: Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets publication-title: Nature doi: 10.1038/359848a0 contributor: fullname: Palabrica – volume: 259 start-page: G300 year: 1990 ident: 10.1016/j.ijcard.2003.10.042_BIB7 article-title: Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence publication-title: Am. J. Physiol. contributor: fullname: Kubes – volume: 93 start-page: 1784 year: 1996 ident: 10.1016/j.ijcard.2003.10.042_BIB9 article-title: Leukocyte adhesion to the coronary microvasculature during ischemia and reperfusion in an in vivo canine model publication-title: Circulation doi: 10.1161/01.CIR.93.10.1784 contributor: fullname: Shreiden – volume: 91 start-page: 2620 year: 1993 ident: 10.1016/j.ijcard.2003.10.042_BIB27 article-title: In vivo neutralization of P-selectin protests ferine heart and endothelium in myocardial ischemia and reperfusion injury publication-title: J. Clin. Invest. doi: 10.1172/JCI116501 contributor: fullname: Weyrich – volume: 92 start-page: 2391 year: 1995 ident: 10.1016/j.ijcard.2003.10.042_BIB28 article-title: Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles: demonstration and potential mechanisms publication-title: Circulation doi: 10.1161/01.CIR.92.9.2391 contributor: fullname: Porter – volume: 34 start-page: 578 year: 1999 ident: 10.1016/j.ijcard.2003.10.042_BIB3 article-title: Flow dynamics of QW7437, a new dodecafluoropentane ultrasound contrast agent, in the microcirculation: microvascular mechanisms for the persistent tissue echo-enhancement publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(99)00209-0 contributor: fullname: Yasu – volume: 106 start-page: 355 year: 1989 ident: 10.1016/j.ijcard.2003.10.042_BIB23 article-title: In vivo visualization of oxyradical-dependent photoemission during endothelium–granulocyte interaction in microvascular beds treated with platelet-activating factor publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a122857 contributor: fullname: Suematsu – volume: 4 start-page: 311 year: 1985 ident: 10.1016/j.ijcard.2003.10.042_BIB15 article-title: Blood flow in contracting arterioles publication-title: Int. J. Microcirc. Clin. Exp. contributor: fullname: Schmid-Schönbein – volume: 19 start-page: 45 year: 1980 ident: 10.1016/j.ijcard.2003.10.042_BIB24 article-title: The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels publication-title: Microvasc. Res. doi: 10.1016/0026-2862(80)90083-7 contributor: fullname: Schmid-Schönbein – volume: 98 start-page: 2187 year: 1998 ident: 10.1016/j.ijcard.2003.10.042_BIB5 article-title: Albumin microbubble persistance during myocardial contrast echocardiography is associated with microvascular endothelial glycocalyx damage publication-title: Circulation doi: 10.1161/01.CIR.98.20.2187 contributor: fullname: Lindner – volume: 340 start-page: 167 year: 1989 ident: 10.1016/j.ijcard.2003.10.042_BIB13 article-title: Stable cell membrane labelling publication-title: Nature doi: 10.1038/340167a0 contributor: fullname: Slezak – volume: 157 start-page: 599 year: 1998 ident: 10.1016/j.ijcard.2003.10.042_BIB18 article-title: Differential contribution of various adhesion molecules to leukocyte kinetics in pulmonary microvessels of hyperoxia-exposed rat lungs publication-title: Am. J. Res. Crit. Care Med. doi: 10.1164/ajrccm.157.2.9704102 contributor: fullname: Nishio – volume: 16 start-page: 1267 year: 1990 ident: 10.1016/j.ijcard.2003.10.042_BIB4 article-title: Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography: an experimental evaluation publication-title: J. Am. Coll. Cardiol. doi: 10.1016/0735-1097(90)90565-7 contributor: fullname: Keller – volume: 98 start-page: 1 year: 1998 ident: 10.1016/j.ijcard.2003.10.042_BIB34 article-title: Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells publication-title: Circulation doi: 10.1161/01.CIR.98.1.1 contributor: fullname: Villanueva – volume: 93 start-page: 1784 year: 1996 ident: 10.1016/j.ijcard.2003.10.042_BIB11 article-title: Leukocyte adhesion to the coronary microvasculature during ischemia and reperfusion in an in vivo canine model publication-title: Circulation doi: 10.1161/01.CIR.93.10.1784 contributor: fullname: Shreiden – volume: 33 start-page: 407A year: 1999 ident: 10.1016/j.ijcard.2003.10.042_BIB22 article-title: New insights into mechanisms of albumin microbubble adhesion to coronary endothelium with chemically modified microbubbles publication-title: J. Am. Coll. Cardiol. (suppl) contributor: fullname: Clay – volume: 29 start-page: 1081 year: 1997 ident: 10.1016/j.ijcard.2003.10.042_BIB29 article-title: Interactions between microbubbles and ultrasound: in vitro and in vivo observations publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(97)00029-6 contributor: fullname: Wei – volume: 15 start-page: 168 year: 1985 ident: 10.1016/j.ijcard.2003.10.042_BIB16 article-title: Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830150211 contributor: fullname: Woollett – volume: 98 start-page: 290 year: 1998 ident: 10.1016/j.ijcard.2003.10.042_BIB30 article-title: Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue publication-title: Circulation doi: 10.1161/01.CIR.98.4.290 contributor: fullname: Skyba
SSID	ssj0004998
Score	1.8467937
Snippet	Purpose: To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed... To characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed microvasculature.... PURPOSETo characterize the flow dynamics of albumin ultrasound contrast microspheres containing perfluoropropane (PFP) in normal and inflamed...
SourceID	proquest crossref pubmed pascalfrancis elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	245
SubjectTerms	Animals Biological and medical sciences Blood Pressure Cardiology. Vascular system Contrast Echocardiography Endothelial Cells - physiology Erythrocytes Fluorocarbons Heart Rate Inflammation - diagnostic imaging Inflammation - physiopathology Kinetics Leukocyte Leukocytes - physiology Male Medical sciences Membrane adhesion Microcirculation Microcirculation - physiology Microscopy, Fluorescence Microspheres Platelet Activating Factor Rats Rats, Wistar Ultrasonography Venules - cytology Venules - pathology
Title	Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules
URI	https://dx.doi.org/10.1016/j.ijcard.2003.10.042 https://www.ncbi.nlm.nih.gov/pubmed/15686774 https://search.proquest.com/docview/19466785 https://search.proquest.com/docview/67400509
Volume	98
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3JbtswECXcBCgKFEX3ukvKQ2-BDEuitqPRukiCtpekQHISSIpq7KhSYFmH_kU_uTOkaMoJjC5AL4JByFo4T8PHwcwbQt4pWLV9X5SeLFTmMVGUnkjkFIhcGpYAgkBI3CgenSZfztMPczYfjawIghv7r5aGMbA1Vs7-hbU3F4UB-A02hyNYHY5_ZPeZ1A3LgEdWqrtq5A8MrGJ0XNUFVltVGCLHcH0LI5e6YGCFxNkyx65ar3iLzZZMGjtv14ffMWuvRQECuBaOmrYSqHlcVl2zasANg1fR-iPwDgAyuD140a7qMxSXLl_ehR8HohVSZ8UOA_wXvO00lvgVr5vVYitPyMDsYvGNb_JDTrioGtuE23SiHqQX9LCfwaJy-GmyFenQleOm1tOE32wJzjGW-cAsuLwnHRkFj49qcmZhM948TZgH_IgN3X2WDmAdDH230bXsaUBghHVvrTAm2LGcLJY4NVpQdoLpgUYj7IZ29yk-FT4UusppjIWm-wF4RHDI-7Pj-fmJK-HNdNvmzVvYKk-dinj7XrtY1P1r3sK3XZqmLLt3TZo9nT0kD_ptD50ZvD4iI1U_Jnc_94kdT8jPDWypgy2F6acD2FINW9rDlm5gS5uSOthSC1s6hC11sKU3YUsXNbWwpT1sn5KvH-dn74-8vlmIJ1ngrz0ppiHjipdlyNMwyUQWyiwUfhEx1MhTIksV-B1fAJ-GVWcaycCXAZdBmQRFGUbhM7JXN7V6QWg8lSriQGJilgLHYyIueQboKBKfA6cMxsSzk59fG02Y3CZLLnNjLGzvGuIoGGtMEmuhvOe1hq_mAKrf_PNgy6DudjFLWJz5Y_LWWjiHdQHNANPWdG3uY-OIJI12nxEnTKs_jclzAw139ShGmUv28p8f_BW5577g12RvverUG3KnLbqDHvm_ADzs_Pw
link.rule.ids	315,782,786,27933,27934
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Activated+leukocytes+and+endothelial+cells+enhance+retention+of+ultrasound+contrast+microspheres+containing+perfluoropropane+in+inflamed+venules&rft.jtitle=International+journal+of+cardiology&rft.au=Yasu%2C+Takanori&rft.au=Greener%2C+Yigal&rft.au=Jablonski%2C+Edward&rft.au=Killam%2C+Anne+L.&rft.date=2005-02-15&rft.pub=Elsevier+Ireland+Ltd&rft.issn=0167-5273&rft.eissn=1874-1754&rft.volume=98&rft.issue=2&rft.spage=245&rft.epage=252&rft_id=info:doi/10.1016%2Fj.ijcard.2003.10.042&rft.externalDocID=S0167527304000609
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-5273&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-5273&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-5273&client=summon