Molecular and pharmacological aspects of antiestrogen resistance

Endocrine therapy is effective in approximately one-third of all breast cancers and up to 80% of tumors that express both estrogen and progesterone receptors. Despite the low toxicity, good overall response rates, and additional benefits associated with its partial agonist activity, most Tamoxifen-r...

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Bibliographic Details
Published in:	Journal of steroid biochemistry and molecular biology Vol. 76; no. 1; pp. 71 - 84
Main Authors:	Clarke, Robert, Skaar, Todd C., Bouker, Kerrie B., Davis, Natalie, Lee, Y.Richard, Welch, James N., Leonessa, Fabio
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Oxford Elsevier Ltd 01-01-2001 Elsevier Science
Subjects:	Antiestrogen resistance Biological and medical sciences Cell Division - drug effects Drug Resistance, Neoplasm Estrogen Receptor Modulators - pharmacology Estrogen Receptor Modulators - therapeutic use Growth Substances - physiology Hormones. Endocrine system Medical sciences Mitogen-Activated Protein Kinases - metabolism Molecular aspects Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - enzymology Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Oxidative Stress Pharmacological aspects Pharmacology. Drug treatments Receptors, Estrogen - metabolism Receptors, Estrogen - physiology Signal Transduction steroid hormones Tamoxifen - pharmacology Tamoxifen - therapeutic use Molecular aspects Pharmacological aspects Antiestrogen resistance Mammary gland diseases Target tissue resistance Antiestrogen Antihormone Review Mammary gland Malignant tumor Non steroid compound Mechanism Tamoxifene Hormonal receptor
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