Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer

• Published in: World journal of gastroenterology : WJG Vol. 17; no. 16; pp. 2109 - 2112
• Main Authors: Kemik, Ozgur, Kemik, Ahu Sarbay, Sümer, Aziz, Dulger, Ahmet Cumhur, Adas, Mine, Begenik, Huseyin, Hasirci, Ismail, Yilmaz, Ozkan, Purisa, Sevim, Kisli, Erol, Tuzun, Sefa, Kotan, Cetin
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 28-04-2011
• Subjects: Adult; Aged; Biomarkers, Tumor - blood; Brief; Disease Progression; Female; Gastrectomy; Humans; Male; Matrix Metalloproteinase 1 - blood; Middle Aged; MMP; Stomach Neoplasms - blood; Stomach Neoplasms - enzymology; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Tissue Inhibitor of Metalloproteinase-1 - blood; 基质金属蛋白酶; 外观形态; 水; 组织抑制剂; 胃癌; 血清; 酶联免疫吸附试验; Matrix metalloproteinase-1; Tissue matrix metalloproteinase-1; Gastric cancer
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i16.2109

AIM：To evaluate the levels of preoperative serum matrix metalloproteinase-1 （MMP-1） and tissue inhibitor of metalloproteinase-1 （TIMP-1） in gastric cancer.METHODS：One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS：Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls （P 〈 0.001）.Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION：Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer.