Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses

2-Amino-3,8-dimethylimidazo[4,5- f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) are heterocyclic amines formed during the cooking of meat and fish. Both are genotoxic in a number of test systems and are carcinogenic in rats and mice. Human exposure to these compoun...

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Bibliographic Details
Published in:	Cancer letters Vol. 143; no. 2; pp. 149 - 155
Main Authors:	Turteltaub, Kenneth W, Dingley, Karen H, Curtis, Kellie D, Malfatti, Michael A, Turesky, Robert J, Colin Garner, R, Felton, James S, Lang, Nicholas P
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-09-1999 Elsevier
Subjects:	2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine 2-Amino-3,8-dimethylimidazo[4,5- f]quinoxaline Accelerator mass spectrometry Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - administration & dosage Carcinogens - metabolism DNA Adducts - metabolism Dose-Response Relationship, Drug Dosimetry Foods and miscellaneous heterocyclic amines Human Humans Imidazoles - administration & dosage Imidazoles - metabolism Macromolecular Substances Medical sciences Mice Quinoxalines - administration & dosage Quinoxalines - metabolism Rats Rodent Tumors Human 2-Amino-3,8-dimethylimidazo[4,5- f]quinoxaline Accelerator mass spectrometry Dosimetry Rodent 2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine Urine Quinoxaline derivatives Hydroxylation Metabolite Toxicity Rodentia Detoxication Bioavailability Mutagen Metabolism Blood Pyridine derivatives Carcinogen Vertebrata Mammalia DNA Arylamine Mass spectrometry Cooked food Heterocyclic compound
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