Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization

Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprote...

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Bibliographic Details
Published in:	Vaccine Vol. 17; no. 15; pp. 2081 - 2088
Main Authors:	Iwasaki, Akiko, Dela Cruz, Charles S, Young, Alex R, Barber, Brian H
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 09-04-1999 Elsevier
Subjects:	Animals Antibodies, Viral - biosynthesis Antigen Presentation Biolistics Biological and medical sciences Cytokines - genetics Cytokines - immunology Cytotoxic T lymphocyte DNA vaccine Epitopes, T-Lymphocyte - administration & dosage Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Female Fundamental and applied biological sciences. Psychology Genes, Viral - genetics Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Injections, Intramuscular Mice Mice, Inbred Strains Microbiology Minigene Nucleoproteins - administration & dosage Nucleoproteins - genetics Nucleoproteins - immunology Nucleoproteins - metabolism Orthomyxoviridae - genetics Orthomyxoviridae - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Peptide Fragments - administration & dosage Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - metabolism Plasmids - genetics Protein Sorting Signals - genetics Recombinant Proteins - biosynthesis Recombinant Proteins - immunology Recombinant Proteins - metabolism RNA-Binding Proteins T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumor Cells, Cultured Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Core Proteins - administration & dosage Viral Core Proteins - genetics Viral Core Proteins - immunology Viral Core Proteins - metabolism Virology DNA vaccine Minigene Cytotoxic T lymphocyte Leader peptide Antigenic determinant Major histocompatibility system Rodentia Cytokine Orthomyxoviridae Interleukin 12 Nucleoprotein Cellular immunity Recombinant DNA Genetic vaccine Virus Vertebrata Mammalia Influenzavirus A Immunogenicity Histocompatibility restriction Mouse Class I histocompatibility antigen Granulocyte macrophage colony stimulating factor
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