Effect of desferrioxamine (DFO) and calcium trinatrium diethylenetriaminepentaacetic acid (DTPA) on rat cytomegalovirus replication in vitro and in vivo

Effect of desferrioxamine (DFO) and calcium trinatrium diethylenetriaminepentaacetic acid (DTPA) on rat cytomegalovirus replication in vitro and in vivo

Cytomegalovirus (CMV) infection is a major problem in the immunosuppressed patient. It is thought that besides direct CMV induced cell lysis, immunological damage is part of CMV pathogenesis. New antiviral drugs, which combine immunomodulating and antiviral qualities, could be beneficial. Recently,...

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Published in:Antiviral research Vol. 44; no. 1; pp. 55 - 65
Main Authors: Kloover, Jeroen S, Scholz, Martin, Cinatl Jr, Jindrich, Lautenschlager, Irmeli, Grauls, Gert E.L.M, Bruggeman, Cathrien A
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 01-11-1999
Elsevier
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antigens, Viral - analysis
Antiviral agents
Antiviral Agents - pharmacology
Biological and medical sciences
Cells, Cultured
Cytomegalovirus
Cytomegalovirus - drug effects
Cytomegalovirus - physiology
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - pathology
Deferoxamine - pharmacology
DFO
DTPA
In vitro
In vivo
Injections, Intraperitoneal
Injections, Subcutaneous
Liver - virology
Medical sciences
Pentetic Acid - pharmacology
Pharmacology. Drug treatments
Rat cytomegalovirus
Rats
Rats, Inbred Lew
Salivary Glands - virology
Spleen - virology
Viral Plaque Assay
Virus Replication - drug effects
DTPA
In vivo
DFO
Rat cytomegalovirus
In vitro
Rat
Murine cytomegalovirus
Herpesviridae
Rodentia
Betaherpesvirinae
Deferoxamine
Infection
Virus
Immunomodulator
Vertebrata
Pentetic acid
Chemotherapy
Mammalia
Treatment
Animal
Viral disease
Antiviral
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Abstract Cytomegalovirus (CMV) infection is a major problem in the immunosuppressed patient. It is thought that besides direct CMV induced cell lysis, immunological damage is part of CMV pathogenesis. New antiviral drugs, which combine immunomodulating and antiviral qualities, could be beneficial. Recently, it has been described that desferrioxamine (DFO) and calcium trinatrium diethylenetriaminepentaacetic acid (DTPA) exhibit both properties. In this report the antiviral effects of both compounds against rat CMV (RCMV) are described in vitro and in vivo using a generalised and local infection model. In vitro , both compounds exhibited a significant antiviral effect, DTPA being more potent than DFO. However, in the generalised infection model no effect was seen on mortality, morbidity or presence of virus in internal organs. In rats infected subcutaneously in the hind paw, no effect was seen locally on paw thickness, presence of viral antigens and inflammatory response. In addition, these rats suffered from a generalised infection of low magnitude at 15 days post infection, although both DFO and DTPA were able to lower the level of viral replication. In conclusion, our data indicate that despite in vitro activity, in vivo usage of DFO or DTPA for acute CMV infection is not warranted.
AbstractList Cytomegalovirus (CMV) infection is a major problem in the immunosuppressed patient. It is thought that besides direct CMV induced cell lysis, immunological damage is part of CMV pathogenesis. New antiviral drugs, which combine immunomodulating and antiviral qualities, could be beneficial. Recently, it has been described that desferrioxamine (DFO) and calcium trinatrium diethylenetriaminepentaacetic acid (DTPA) exhibit both properties. In this report the antiviral effects of both compounds against rat CMV (RCMV) are described in vitro and in vivo using a generalised and local infection model. In vitro, both compounds exhibited a significant antiviral effect, DTPA being more potent than DFO. However, in the generalised infection model no effect was seen on mortality, morbidity or presence of virus in internal organs. In rats infected subcutaneously in the hind paw, no effect was seen locally on paw thickness, presence of viral antigens and inflammatory response. In addition, these rats suffered from a generalised infection of low magnitude at 15 days post infection, although both DFO and DTPA were able to lower the level of viral replication. In conclusion, our data indicate that despite in vitro activity, in vivo usage of DFO or DTPA for acute CMV infection is not warranted.
Cytomegalovirus (CMV) infection is a major problem in the immunosuppressed patient. It is thought that besides direct CMV induced cell lysis, immunological damage is part of CMV pathogenesis. New antiviral drugs, which combine immunomodulating and antiviral qualities, could be beneficial. Recently, it has been described that desferrioxamine (DFO) and calcium trinatrium diethylenetriaminepentaacetic acid (DTPA) exhibit both properties. In this report the antiviral effects of both compounds against rat CMV (RCMV) are described in vitro and in vivo using a generalised and local infection model. In vitro , both compounds exhibited a significant antiviral effect, DTPA being more potent than DFO. However, in the generalised infection model no effect was seen on mortality, morbidity or presence of virus in internal organs. In rats infected subcutaneously in the hind paw, no effect was seen locally on paw thickness, presence of viral antigens and inflammatory response. In addition, these rats suffered from a generalised infection of low magnitude at 15 days post infection, although both DFO and DTPA were able to lower the level of viral replication. In conclusion, our data indicate that despite in vitro activity, in vivo usage of DFO or DTPA for acute CMV infection is not warranted.
Author Kloover, Jeroen S
Cinatl Jr, Jindrich
Scholz, Martin
Lautenschlager, Irmeli
Grauls, Gert E.L.M
Bruggeman, Cathrien A
Author_xml – sequence: 1
  givenname: Jeroen S
  surname: Kloover
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  organization: Department of Medical Microbiology, P.O. Box 5800, 6200 AZ Maastricht, University of Maastricht, Maastricht, The Netherlands
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  givenname: Martin
  surname: Scholz
  fullname: Scholz, Martin
  organization: Institute of Medical Virology, J.W. Goethe University, Frankfurt am Main, Germany
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  surname: Cinatl Jr
  fullname: Cinatl Jr, Jindrich
  organization: Institute of Medical Virology, J.W. Goethe University, Frankfurt am Main, Germany
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  givenname: Irmeli
  surname: Lautenschlager
  fullname: Lautenschlager, Irmeli
  organization: Department of Virology, Helsinki University Central Hospital, Helsinki, Finland
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  givenname: Gert E.L.M
  surname: Grauls
  fullname: Grauls, Gert E.L.M
  organization: Department of Medical Microbiology, P.O. Box 5800, 6200 AZ Maastricht, University of Maastricht, Maastricht, The Netherlands
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  givenname: Cathrien A
  surname: Bruggeman
  fullname: Bruggeman, Cathrien A
  email: aee@lmib.azm.nl
  organization: Department of Medical Microbiology, P.O. Box 5800, 6200 AZ Maastricht, University of Maastricht, Maastricht, The Netherlands
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Issue 1
Keywords DTPA
In vivo
DFO
Rat cytomegalovirus
In vitro
Rat
Murine cytomegalovirus
Herpesviridae
Rodentia
Betaherpesvirinae
Deferoxamine
Infection
Virus
Immunomodulator
Vertebrata
Pentetic acid
Chemotherapy
Mammalia
Treatment
Animal
Viral disease
Antiviral
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Snippet Cytomegalovirus (CMV) infection is a major problem in the immunosuppressed patient. It is thought that besides direct CMV induced cell lysis, immunological...
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SubjectTerms Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antigens, Viral - analysis
Antiviral agents
Antiviral Agents - pharmacology
Biological and medical sciences
Cells, Cultured
Cytomegalovirus
Cytomegalovirus - drug effects
Cytomegalovirus - physiology
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - pathology
Deferoxamine - pharmacology
DFO
DTPA
In vitro
In vivo
Injections, Intraperitoneal
Injections, Subcutaneous
Liver - virology
Medical sciences
Pentetic Acid - pharmacology
Pharmacology. Drug treatments
Rat cytomegalovirus
Rats
Rats, Inbred Lew
Salivary Glands - virology
Spleen - virology
Viral Plaque Assay
Virus Replication - drug effects
Title Effect of desferrioxamine (DFO) and calcium trinatrium diethylenetriaminepentaacetic acid (DTPA) on rat cytomegalovirus replication in vitro and in vivo
URI https://dx.doi.org/10.1016/S0166-3542(99)00054-6
https://www.ncbi.nlm.nih.gov/pubmed/10588333
https://search.proquest.com/docview/17349175
https://search.proquest.com/docview/69332910
Volume 44
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