Natural products as catalysts for innovation: a pharmaceutical industry perspective

Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional...

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Bibliographic Details
Published in:	Current opinion in chemical biology Vol. 15; no. 4; pp. 497 - 504
Main Authors:	Schmitt, Esther K, Moore, Charles M, Krastel, Philipp, Petersen, Frank
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2011
Subjects:	Biodiversity Biological Products - chemistry Drug Discovery - methods Drug Industry - methods Epigenomics - methods Genome High-Throughput Screening Assays - methods Humans Molecular Probes - chemistry Molecular Structure Technology, Pharmaceutical - methods
Online Access:	Get full text
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Summary:	Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1367-5931 1879-0402
DOI:	10.1016/j.cbpa.2011.05.018