Long-term nifedipine unloading therapy in asymptomatic patients with chronic severe aortic regurgitation

• Published in: Journal of the American College of Cardiology Vol. 16; no. 2; pp. 424 - 429
• Main Authors: Scognamiglio, Roldano, Fasoli, Giuseppe, Ponchia, Andrea, Dalla-Volta, Sergio
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-08-1990; Elsevier Science
• Subjects: Adult; Aortic Valve Insufficiency - drug therapy; Aortic Valve Insufficiency - pathology; Aortic Valve Insufficiency - physiopathology; Biological and medical sciences; Cardiovascular system; Chronic Disease; Double-Blind Method; Echocardiography; Female; Follow-Up Studies; Heart Ventricles - drug effects; Hemodynamics - drug effects; Humans; Male; Medical sciences; Middle Aged; Nifedipine - adverse effects; Nifedipine - therapeutic use; Pharmacology. Drug treatments; Prospective Studies; Randomized Controlled Trials as Topic; Stress, Mechanical; Stroke Volume - drug effects; Vasodilator agents. Cerebral vasodilators; Human; Vasodilator agent; Ultrasonic investigation; Calcium antagonist; Cardiovascular disease; Aortic valve disease; Long term; Result; Thickness; Chemotherapy; Treatment; Regurgitation; Myocardium; Left ventricle performance; Aortic valve
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/0735-1097(90)90596-H

Vasodilating agents acutely reduce regurgitant volume and improve left ventricular performance in aortic regurgitation, but more information is necessary about their long-term efficacy. To evaluate the effects of 12 months of therapy with nifedipine, a randomized, double-blind, placebo-controlled trial was performed in 72 asymptomatic patients with severe aortic regurgitation.
At 12 months, patients receiving nifedipine had a significant reduction in left ventricular end-diastolic volume index (110 ± 19 versus 136 ± 22 ml/m2, p < 0.01) and mass (115 ± 19 versus 142 ± 16 g/m2, p < 0.01) measured by two-dimensional echocardiography. They also had a reduction in left ventricular mean wall stress (360 ± 27 versus 479 ± 36 kdyne/cm2, p < 0.001) and an increase in ejection fraction (72 ± 8% versus 60 ± 6%, p < 0.05).
These data show that the long-term unloading action of nifedipine is able to reverse left ventricular dilation and hypertrophy and suggest that such therapy has the potential to delay the need for valve replacement in asymptomatic patients.