Retrospective review comparing intrapleural fibrinolytic therapy (alteplase) and surgical intervention in complex pleural effusion

• Published in: BMC pulmonary medicine Vol. 22; no. 1; pp. 1 - 439
• Main Authors: Abdul Hamid, Mohamed Faisal, Hasbullah, Ahmad Hadyan Husainy, Mohamad Jailaini, Mas Fazlin, Nik Abeed, Nik Nuratiqah, Ng, Boon Hau, Haron, Hairulfaizi, Md Ali, Nur Ayub, Ismail, Muhammad Ishamuddin, Nik Ismail, Nik Azuan, Abdul Rahman, Mohd Ramzisham, Ban, Andrea Yu-Lin
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 23-11-2022; BioMed Central; BMC
• Subjects: Antibiotics; Care and treatment; Chest; Clinical respiratory medicine; Diagnosis; Dosage and administration; Fibrin; Infections; Inflammation; Normal distribution; Patients; Pleural disease; Pleural effusion; Pleural effusions; Pulmonology; Respiratory infection; Sepsis; Surgery; t-Plasminogen activator; Thoracic surgery; Tissue plasminogen activator; Ultrasonic imaging; Malaysia
• ISSN: 1471-2466; 1471-2466
• DOI: 10.1186/s12890-022-02239-w

Background Intrapleural fibrinolytic therapy (IPFT) is one of the treatment options for complex pleural effusion. In this study, the IPFT agent used was alteplase, a tissue plasminogen activator (t-PA). This study aims to determine the difference in the outcome of patients with complex pleural effusion between IPFT and surgery in terms of radiological improvement, inflammatory parameters, length of stay, and post-intervention complications. Methods A retrospective review of patients with complex pleural effusion treated at Universiti Kebangsaan Malaysia Medical Center from January 2012 to August 2020 was performed. Patient demographics, chest imaging, drainage chart, inflammatory parameters, length of hospital stay, and post-intervention and outcome were analyzed. Results Fifty-eight patients were identified (surgical intervention, n = 18; 31% and IPFT, n = 40, 69%). The mean age was 51.7 [+ or -] 18.2 years. Indication for surgical intervention was pleural infection (n = 18; 100%), and MPE (n = 0). Indications for IPFT was pleural infection (n = 30; 75%) and MPE (n = 10; 25%). The dosages of t-PA were one to five doses of 2-50 mg. The baseline chest radiograph in the IPFT group was worse than in the surgical intervention group. (119.96 [+ or -] 56.05 vs. 78.19 [+ or -] 55.6; p = 0.029) At week 1, the radiological success rate for IPFT and surgical intervention were 27% and 20%, respectively, and at weeks 4-8, the success rate was 56% and 80% respectively. IPFT was associated with lesser complications; fever (17.5%), chest pain (10%), and non-life-threatening bleeding (5%). Conclusion IPFT was comparable to surgery in radiological outcome, inflammatory parameters, and length of stay with lesser reported complications. Keywords: Thoracic surgery, Respiratory infection, Clinical respiratory medicine, Pleural disease