Severe multisystem inflammatory syndrome in a vaccinated adult with COVID-19

• Published in: BMJ case reports Vol. 15; no. 4; p. e249425
• Main Authors: Selvaraj, Vijairam, Finn, Arkadiy, Santos, Michael, Dapaah-Afriyie, Kwame
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 26-04-2022; BMJ Publishing Group
• Subjects: Adult; Antibodies; Antigens; Case reports; Case Reports: Rare disease; Child; Coronaviruses; COVID-19 - complications; COVID-19 vaccines; Extubation; Health care; Heart rate; Hospitals; Humans; Illnesses; Immunoglobulins; Infections; Inflammatory diseases; Kawasaki disease; Multiple organ dysfunction syndrome; Pathophysiology; Patients; Pneumonia; Proteins; Pulmonary arteries; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Systemic Inflammatory Response Syndrome; Medical education; Intensive care; Immunology; Infectious diseases; Medical management
• ISSN: 1757-790X; 1757-790X
• DOI: 10.1136/bcr-2022-249425

The ability of SARS-CoV-2 to trigger hyperinflammatory response in children and adults is increasingly recognised. However, the detailed features that distinguish severe COVID-19-associated hyperinflammation from multisystem inflammatory syndrome in adults (MIS-A) is not yet known. We describe a young, vaccinated patient with no prior SARS-CoV-2 exposure who developed COVID-19 and MIS-A. We also provide a review of the current literature on MIS-A and COVID-19-associated hyperinflammation.