Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL

STUDY QUESTION Does inhibition of dimethylarginine dimethylaminohydrolase (DDAH) increase the sensitivity of trophoblasts to TRAIL-induced apoptosis? SUMMARY ANSWER Inhibition of DDAH1, but not DDAH2, increases the sensitivity of trophoblasts to TRAIL-induced apoptosis. WHAT IS KNOWN ALREADY Success...

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Bibliographic Details
Published in:	Human reproduction (Oxford) Vol. 30; no. 8; pp. 1813 - 1819
Main Authors:	Lumicisi, B.A., Cartwright, J.E., Leslie, K., Wallace, A.E., Whitley, G.S.
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-08-2015
Subjects:	Amidohydrolases - genetics Amidohydrolases - metabolism Apoptosis - drug effects Apoptosis - genetics Cell Line Humans Original Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism RNA, Small Interfering TNF-Related Apoptosis-Inducing Ligand - pharmacology Trophoblasts - drug effects Trophoblasts - metabolism DDAH apoptosis ADMA extravillous trophoblast TRAIL
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