Formation and fate of platelet microparticles

There is increasing evidence that platelet microparticles participate in thrombus formation. Yet the origin of platelet microparticles and their fate in the circulation remain poorly defined. It is unknown, for example, whether circulating platelet microparticles found in healthy individuals are der...

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Bibliographic Details
Published in:	Blood cells, molecules, & diseases Vol. 36; no. 2; pp. 182 - 187
Main Author:	Flaumenhaft, Robert
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2006
Subjects:	Blood Platelets - metabolism Blood Platelets - ultrastructure Cell Membrane - chemistry Clearance Complement Humans Macromolecular Substances - chemistry Macromolecular Substances - metabolism Megakaryocyte Megakaryocytes Microparticle Particle Size Phosphatidylinositol 4,5-bisphosphate (PIP 2) Phospholipids Platelet Thrombosis - etiology Phosphatidylinositol 4,5-bisphosphate (PIP 2) Megakaryocyte Microparticle Platelet Complement Clearance
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Summary:	There is increasing evidence that platelet microparticles participate in thrombus formation. Yet the origin of platelet microparticles and their fate in the circulation remain poorly defined. It is unknown, for example, whether circulating platelet microparticles found in healthy individuals are derived from activated platelets or generated during megakaryopoiesis. The life span of platelet microparticles and the mechanism of their clearance have also not been determined. This article addresses these fundamental aspects of the physiology of platelet microparticles.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1079-9796 1096-0961
DOI:	10.1016/j.bcmd.2005.12.019