Understanding the role of AMPA receptors in autism: insights from circuit and synapse dysfunction
Autism spectrum disorders represent a diverse etiological spectrum that converge on a syndrome characterized by discrepant deficits in developmental domains often highlighted by concerns in socialization, sensory integration, and autonomic functioning. Importantly, the incidence and prevalence of au...
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| Published in: | Frontiers in psychiatry Vol. 15; p. 1304300 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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| Abstract | Autism spectrum disorders represent a diverse etiological spectrum that converge on a syndrome characterized by discrepant deficits in developmental domains often highlighted by concerns in socialization, sensory integration, and autonomic functioning. Importantly, the incidence and prevalence of autism spectrum disorders have seen sharp increases since the syndrome was first described in the 1940s. The wide etiological spectrum and rising number of individuals being diagnosed with the condition lend urgency to capturing a more nuanced understanding of the pathogenic mechanisms underlying the autism spectrum disorders. The current review seeks to understand how the disruption of AMPA receptor (AMPAr)-mediated neurotransmission in the cerebro-cerebellar circuit, particularly in genetic autism related to SHANK3 or SYNGAP1 protein dysfunction function and autism associated with
exposure to the anti-seizure medications valproic acid and topiramate, may contribute to the disease presentation. Initially, a discussion contextualizing AMPAr signaling in the cerebro-cerebellar circuitry and microstructural circuit considerations is offered. Subsequently, a detailed review of the literature implicating mutations or deletions of
and
in disrupted AMPAr signaling reveals how bidirectional pathogenic modulation of this key circuit may contribute to autism. Finally, how pharmacological exposure may interact with this pathway,
increased risk of autism diagnosis with valproic acid and topiramate exposure and potential treatment of autism using AMPAr modulator perampanel, is discussed. Through the lens of the review, we will offer speculation on how neuromodulation may be used as a rational adjunct to therapy. Together, the present review seeks to synthesize the disparate considerations of circuit understanding, genetic etiology, and pharmacological modulation to understand the mechanistic interaction of this important and complex disorder. |
|---|---|
| AbstractList | Autism spectrum disorders represent a diverse etiological spectrum that converge on a syndrome characterized by discrepant deficits in developmental domains often highlighted by concerns in socialization, sensory integration, and autonomic functioning. Importantly, the incidence and prevalence of autism spectrum disorders have seen sharp increases since the syndrome was first described in the 1940s. The wide etiological spectrum and rising number of individuals being diagnosed with the condition lend urgency to capturing a more nuanced understanding of the pathogenic mechanisms underlying the autism spectrum disorders. The current review seeks to understand how the disruption of AMPA receptor (AMPAr)-mediated neurotransmission in the cerebro-cerebellar circuit, particularly in genetic autism related to SHANK3 or SYNGAP1 protein dysfunction function and autism associated with
in utero
exposure to the anti-seizure medications valproic acid and topiramate, may contribute to the disease presentation. Initially, a discussion contextualizing AMPAr signaling in the cerebro-cerebellar circuitry and microstructural circuit considerations is offered. Subsequently, a detailed review of the literature implicating mutations or deletions of
SHANK3
and
SYNGAP1
in disrupted AMPAr signaling reveals how bidirectional pathogenic modulation of this key circuit may contribute to autism. Finally, how pharmacological exposure may interact with this pathway,
via
increased risk of autism diagnosis with valproic acid and topiramate exposure and potential treatment of autism using AMPAr modulator perampanel, is discussed. Through the lens of the review, we will offer speculation on how neuromodulation may be used as a rational adjunct to therapy. Together, the present review seeks to synthesize the disparate considerations of circuit understanding, genetic etiology, and pharmacological modulation to understand the mechanistic interaction of this important and complex disorder. Autism spectrum disorders represent a diverse etiological spectrum that converge on a syndrome characterized by discrepant deficits in developmental domains often highlighted by concerns in socialization, sensory integration, and autonomic functioning. Importantly, the incidence and prevalence of autism spectrum disorders have seen sharp increases since the syndrome was first described in the 1940s. The wide etiological spectrum and rising number of individuals being diagnosed with the condition lend urgency to capturing a more nuanced understanding of the pathogenic mechanisms underlying the autism spectrum disorders. The current review seeks to understand how the disruption of AMPA receptor (AMPAr)-mediated neurotransmission in the cerebro-cerebellar circuit, particularly in genetic autism related to SHANK3 or SYNGAP1 protein dysfunction function and autism associated with in utero exposure to the anti-seizure medications valproic acid and topiramate, may contribute to the disease presentation. Initially, a discussion contextualizing AMPAr signaling in the cerebro-cerebellar circuitry and microstructural circuit considerations is offered. Subsequently, a detailed review of the literature implicating mutations or deletions of SHANK3 and SYNGAP1 in disrupted AMPAr signaling reveals how bidirectional pathogenic modulation of this key circuit may contribute to autism. Finally, how pharmacological exposure may interact with this pathway, via increased risk of autism diagnosis with valproic acid and topiramate exposure and potential treatment of autism using AMPAr modulator perampanel, is discussed. Through the lens of the review, we will offer speculation on how neuromodulation may be used as a rational adjunct to therapy. Together, the present review seeks to synthesize the disparate considerations of circuit understanding, genetic etiology, and pharmacological modulation to understand the mechanistic interaction of this important and complex disorder.Autism spectrum disorders represent a diverse etiological spectrum that converge on a syndrome characterized by discrepant deficits in developmental domains often highlighted by concerns in socialization, sensory integration, and autonomic functioning. Importantly, the incidence and prevalence of autism spectrum disorders have seen sharp increases since the syndrome was first described in the 1940s. The wide etiological spectrum and rising number of individuals being diagnosed with the condition lend urgency to capturing a more nuanced understanding of the pathogenic mechanisms underlying the autism spectrum disorders. The current review seeks to understand how the disruption of AMPA receptor (AMPAr)-mediated neurotransmission in the cerebro-cerebellar circuit, particularly in genetic autism related to SHANK3 or SYNGAP1 protein dysfunction function and autism associated with in utero exposure to the anti-seizure medications valproic acid and topiramate, may contribute to the disease presentation. Initially, a discussion contextualizing AMPAr signaling in the cerebro-cerebellar circuitry and microstructural circuit considerations is offered. Subsequently, a detailed review of the literature implicating mutations or deletions of SHANK3 and SYNGAP1 in disrupted AMPAr signaling reveals how bidirectional pathogenic modulation of this key circuit may contribute to autism. Finally, how pharmacological exposure may interact with this pathway, via increased risk of autism diagnosis with valproic acid and topiramate exposure and potential treatment of autism using AMPAr modulator perampanel, is discussed. Through the lens of the review, we will offer speculation on how neuromodulation may be used as a rational adjunct to therapy. Together, the present review seeks to synthesize the disparate considerations of circuit understanding, genetic etiology, and pharmacological modulation to understand the mechanistic interaction of this important and complex disorder. Autism spectrum disorders represent a diverse etiological spectrum that converge on a syndrome characterized by discrepant deficits in developmental domains often highlighted by concerns in socialization, sensory integration, and autonomic functioning. Importantly, the incidence and prevalence of autism spectrum disorders have seen sharp increases since the syndrome was first described in the 1940s. The wide etiological spectrum and rising number of individuals being diagnosed with the condition lend urgency to capturing a more nuanced understanding of the pathogenic mechanisms underlying the autism spectrum disorders. The current review seeks to understand how the disruption of AMPA receptor (AMPAr)-mediated neurotransmission in the cerebro-cerebellar circuit, particularly in genetic autism related to SHANK3 or SYNGAP1 protein dysfunction function and autism associated with in utero exposure to the anti-seizure medications valproic acid and topiramate, may contribute to the disease presentation. Initially, a discussion contextualizing AMPAr signaling in the cerebro-cerebellar circuitry and microstructural circuit considerations is offered. Subsequently, a detailed review of the literature implicating mutations or deletions of SHANK3 and SYNGAP1 in disrupted AMPAr signaling reveals how bidirectional pathogenic modulation of this key circuit may contribute to autism. Finally, how pharmacological exposure may interact with this pathway, via increased risk of autism diagnosis with valproic acid and topiramate exposure and potential treatment of autism using AMPAr modulator perampanel, is discussed. Through the lens of the review, we will offer speculation on how neuromodulation may be used as a rational adjunct to therapy. Together, the present review seeks to synthesize the disparate considerations of circuit understanding, genetic etiology, and pharmacological modulation to understand the mechanistic interaction of this important and complex disorder. Autism spectrum disorders represent a diverse etiological spectrum that converge on a syndrome characterized by discrepant deficits in developmental domains often highlighted by concerns in socialization, sensory integration, and autonomic functioning. Importantly, the incidence and prevalence of autism spectrum disorders have seen sharp increases since the syndrome was first described in the 1940s. The wide etiological spectrum and rising number of individuals being diagnosed with the condition lend urgency to capturing a more nuanced understanding of the pathogenic mechanisms underlying the autism spectrum disorders. The current review seeks to understand how the disruption of AMPA receptor (AMPAr)-mediated neurotransmission in the cerebro-cerebellar circuit, particularly in genetic autism related to SHANK3 or SYNGAP1 protein dysfunction function and autism associated with exposure to the anti-seizure medications valproic acid and topiramate, may contribute to the disease presentation. Initially, a discussion contextualizing AMPAr signaling in the cerebro-cerebellar circuitry and microstructural circuit considerations is offered. Subsequently, a detailed review of the literature implicating mutations or deletions of and in disrupted AMPAr signaling reveals how bidirectional pathogenic modulation of this key circuit may contribute to autism. Finally, how pharmacological exposure may interact with this pathway, increased risk of autism diagnosis with valproic acid and topiramate exposure and potential treatment of autism using AMPAr modulator perampanel, is discussed. Through the lens of the review, we will offer speculation on how neuromodulation may be used as a rational adjunct to therapy. Together, the present review seeks to synthesize the disparate considerations of circuit understanding, genetic etiology, and pharmacological modulation to understand the mechanistic interaction of this important and complex disorder. |
| Author | Nguyen, Megan X Jimenez-Gomez, Andres Gill, Jason S |
| AuthorAffiliation | 2 Department of Pediatrics, Division of Neurology & Developmental Neurosciences, Baylor College of Medicine , Houston, TX , United States 1 Neurodevelopmental Disabilities Program, Department of Neurology, Joe DiMaggio Children’s Hospital , Hollywood, FL , United States 3 Jan & Dan Duncan Neurologic Research Institute, Texas Children’s Hospital , Houston, TX , United States |
| AuthorAffiliation_xml | – name: 1 Neurodevelopmental Disabilities Program, Department of Neurology, Joe DiMaggio Children’s Hospital , Hollywood, FL , United States – name: 3 Jan & Dan Duncan Neurologic Research Institute, Texas Children’s Hospital , Houston, TX , United States – name: 2 Department of Pediatrics, Division of Neurology & Developmental Neurosciences, Baylor College of Medicine , Houston, TX , United States |
| Author_xml | – sequence: 1 givenname: Andres surname: Jimenez-Gomez fullname: Jimenez-Gomez, Andres organization: Neurodevelopmental Disabilities Program, Department of Neurology, Joe DiMaggio Children's Hospital, Hollywood, FL, United States – sequence: 2 givenname: Megan X surname: Nguyen fullname: Nguyen, Megan X organization: Jan & Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX, United States – sequence: 3 givenname: Jason S surname: Gill fullname: Gill, Jason S organization: Jan & Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38352654$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/epi.17530 10.3389/fgene.2022.652454 10.1016/j.tins.2015.10.002 10.1177/1362361318815662 10.1186/2040-2392-4-9 10.3389/fnins.2021.761473 10.1021/pr500697b 10.1016/j.neuron.2019.04.021 10.1136/jmedgenet-2015-103451 10.1016/j.reprotox.2012.05.038 10.1097/00005072-199807000-00001 10.1523/ENEURO.0475-22.2023 10.1016/j.eplepsyres.2020.106452 10.1016/j.tins.2021.08.005 10.1523/JNEUROSCI.4256-04.2005 10.1159/000515189 10.1038/ncomms1565 10.1016/j.neuron.2019.02.041 10.1016/j.cub.2021.09.022 10.1186/s11689-019-9276-y 10.1111/fwb.12896 10.3389/fncel.2016.00032 10.1159/000437413 10.1038/ncomms1900 10.1007/s13311-015-0352-z 10.3389/fnmol.2023.1191323 10.1017/S0012162205001076 10.3389/fnins.2015.00408 10.1038/s41380-021-01230-x 10.1007/s00431-022-04564-y 10.1523/JNEUROSCI.3213-04.2004 10.3389/fncel.2019.00385 10.1055/s-0043-1771460 10.7554/eLife.68045 10.1038/s41380-021-01023-2 10.1016/j.seizure.2023.01.008 10.3389/fneur.2023.1221161 10.1186/1471-2121-9-66 10.1097/MD.0000000000006696 10.1136/bmjopen-2019-034829 10.2174/15665240113139990019 10.1016/j.biopsych.2015.03.024 10.1016/j.mcn.2018.03.008 10.3390/ph16010001 10.1038/nrn1430 10.1016/j.neuron.2014.07.016 10.1016/j.cell.2012.08.045 10.1186/2040-2392-1-15 10.1016/j.neuron.2016.01.040 10.3389/fnmol.2019.00097 10.1002/ajmg.a.40666 10.1016/0169-328X(95)00021-J 10.1016/j.neulet.2023.137305 10.3389/fncel.2019.00441 10.1016/j.neuroscience.2020.06.010 10.1034/j.1601-183X.2003.00037.x 10.1038/266737a0 10.1002/aur.2696 10.1001/jama.2022.23661 10.1001/jama.2013.2270 10.1007/s12035-023-03560-z 10.1113/jphysiol.1973.sp010273 10.1542/peds.2007-1041 10.1038/s41593-019-0445-9 10.1111/epi.17825 10.1186/s11689-018-9225-1 10.1016/j.eplepsyres.2021.106550 10.1016/j.biopsych.2019.12.025 10.1016/j.brainres.2008.12.076 10.1186/s12915-023-01712-0 10.3389/fnhum.2022.918918 10.1016/j.biopsych.2014.08.001 10.1073/pnas.1512913112 10.1016/j.neuron.2016.11.007 10.1016/j.euroneuro.2021.02.017 10.1523/JNEUROSCI.16-06-01982.1996 10.3389/fnins.2021.751364 10.1136/jnnp-2018-318386 10.1056/NEJMoa0805392 10.1146/annurev-publhealth-031816-044318 10.1523/JNEUROSCI.0765-13.2013 10.1016/j.neuron.2004.08.003 10.1001/JAMANEUROL.2022.1269 10.1212/01.wnl.0000339399.64213.1a 10.1093/brain/121.5.889 10.1016/S0140-6736(18)31129-2 10.15585/mmwr.ss7202a1 10.1177/1533317513518645 10.1002/AJMG.A.63312 10.1073/pnas.0600084103 10.1016/j.seizure.2023.03.009 10.1016/j.cell.2010.01.026 10.1186/s11689-021-09397-8 10.1523/JNEUROSCI.1367-20.2020 10.1038/nature16971 10.1001/jamapediatrics.2023.4003 10.3389/fneur.2023.1182304 10.1111/epi.14689 10.1159/000503840 10.1038/s41598-019-45667-1 10.1016/j.isci.2019.06.014 10.1016/j.cub.2014.08.056 10.3389/fnana.2010.00012 10.1097/WCO.0000000000000186 10.3389/FNINS.2015.00408 10.3389/fnagi.2021.717263 10.1016/j.neuroscience.2021.09.013 10.1111/jnc.13523 10.1016/j.ejmg.2023.104746 10.1093/acprof:oso/9780195182224.003.0003 10.1016/j.neuron.2014.08.044 10.1016/j.neuron.2014.12.023 10.1016/j.celrep.2019.04.085 10.1523/JNEUROSCI.2529-18.2019 10.1002/aur.1529 10.1212/WNL.0000000000006729 10.1073/pnas.2100579118 10.1016/j.neuron.2016.12.015 10.1371/journal.pone.0083941 10.7554/eLife.35696 10.1111/j.1471-4159.2006.03831.x 10.3390/brainsci12020137 10.1371/journal.pone.0258766 10.1007/s11064-022-03623-y 10.1073/pnas.090504197 10.1016/j.cell.2019.12.036 10.1038/s41398-018-0142-6 10.1016/j.yebeh.2005.05.022 10.1023/B:NERE.0000010456.92887.3b 10.1152/jn.00339.2011 10.1016/j.pediatrneurol.2018.09.008 10.1016/j.clinph.2021.01.014 10.1016/j.expneurol.2017.04.017 10.1002/ajmg.a.35700 10.1007/s10803-021-04904-1 10.1016/B978-0-12-418675-0.00004-3 10.1038/nrn.2016.183 10.1212/WNL.57.9.1618 10.1146/annurev.ne.18.030195.001535 10.1523/JNEUROSCI.2725-12.2013 10.1523/JNEUROSCI.23-18-07069.2003 10.1016/j.neuron.2014.05.015 10.1002/aur.2898 10.1016/S1474-4422(13)70011-5 10.1172/JCI87997 |
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| Copyright | Copyright © 2024 Jimenez-Gomez, Nguyen and Gill. Copyright © 2024 Jimenez-Gomez, Nguyen and Gill 2024 Jimenez-Gomez, Nguyen and Gill |
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| Keywords | cerebro-cerebellar ASD AMPA synaptopathy SHANK3 SynGAP1 autism circuits |
| Language | English |
| License | Copyright © 2024 Jimenez-Gomez, Nguyen and Gill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| References | Sullivan (B150) 2020; 87 Blotière (B141) 2020; 10 Herculano-Houzel (B22) 2015; 86 Bliss (B66) 1973; 232 Zhang (B112) 2021; 15 Perversi (B146) 2023; 14 Weldon (B57) 2018; 10 Khlaifia (B130) 2023; 10 Kim (B138) 2018; 44 Smaers (B18) 2018; 7 Kanner (B4) 1943; 2 Waizbard-Bartov (B11) 2023; 16 Wang (B13) 2017; 96 Paul (B60) 2019; 12 Nicoll (B65) 2017; 93 Aldinger (B91) 2013; 161 Nissenkorn (B148) 2023; 64 Han (B78) 2016; 92 Braillon (B143) 2023; 107 Smaers (B17) 2014 Bradshaw (B2) 2019; 23 Noonan (B35) 2009; 1262 Spisák (B137) 2019; 9 Araki (B116) 2015; 85 Li (B88) 2021; 15 Mcafee (B49) 2019; 27 Kros (B32) 2015; 38 Monteiro (B53) 2017; 18 Tanaka (B37) 2005; 25 van der Heijden (B42) 2021; 462 Wan (B85) 2021; 13 Clement (B126) 2012; 151 Diedrichsen (B39) 2019; 102 Rosen (B9) 2021; 51 Llamosas (B119) 2021; 118 Ebrahimi-Fakhari (B16) 2015; 28 Ozkan (B125) 2014; 82 Rumbaugh (B118) 2006; 103 Salomaa (B86) 2021; 31 Lyall (B5) 2017; 38 Satterstrom (B83) 2020; 180 D’Mello (B24) 2015; 9 Baron (B30) 1981; 105 Mignot (B113) 2016; 53 Ross (B101) 2023; 809 Wu (B117) 2022; 47 Lynch (B68) 1977; 266 D’urso (B151) 2022; 11 Chen (B47) 2014; 13 Vlaskamp (B110) 2019; 92 Rasalam (B134) 2005; 47 Pagani (B89) 2019; 39 Limperopoulos (B26) 2007; 120 Purcell (B46) 2001; 57 Wang (B94) 2017; 127 Gupta (B147) 2023; 14 Droogmans (B76) 2020; 10 Rubenstein (B14) 2003; 2 Moreno-De-Luca (B153) 2013; 12 D’Angelo (B36) 2021 Bozdagi (B105) 2013; 4 Bjørk (B131) 2022; 79 Nevado (B74) 2022; 13 Srivastava (B81) 2023; 191 Molloy (B84) 2023; 16 Fukushima (B144) 2020; 167 de Coo (B82) 2023; 66 Niescier (B50) 2021; 479 Rihtman (B139) 2012; 34 Srivastava (B90) 2019; 90 Clement (B124) 2013; 33 Maenner (B7) 2023; 72 Rylaarsdam (B3) 2019; 13 Li (B77) 2018; 176 Wang (B1) 2014; 83 Jeyabalan (B59) 2016; 10 Poulsen (B64) 2004; 29 Harstad (B12) 2023; 177 Chiola (B97) 2021; 26 Hermann (B31) 2005; 7 B106 Bailey (B27) 1998; 121 Raynaud (B100) 2013; 33 Llamosas (B128) 2020; 40 Guo (B93) 2019; 22 Bromley (B133) 2008; 71 Alachkar (B72) 2013; 13 Bagni (B15) 2019; 101 Allen (B29) 2005; 2 Allen (B33) 2019; 60 Moutin (B98) 2021; 26 Buckner (B38) 2011; 106 Rogawski (B132) 2004; 5 Chen (B63) 2023; 61 Lo Barco (B111) 2021; 132 Lee (B92) 2022; 16 Qin (B104) 2019; 17 Zhang (B23) 2002; 97 Kemper (B28) 1998; 57 Niesmann (B71) 2011; 2 Bey (B95) 2018; 8 Aguilera (B108) 2021; 16 Wang (B115) 2013; 8 Zeidan (B8) 2022; 15 Barton (B21) 2014; 24 van der Heijden (B41) 2021; 10 Shin (B136) 2023; 65 Van Der Heijden (B25) 2021 Woelfle (B87) 2023; 21 Khan (B34) 2015; 78 McMahon (B120) 2012; 12 Hirota (B10) 2023; 329 Herculano-Houzel (B19) 2010; 4 B75 Day (B40) 1995; 31 Lord (B6) 2018; 392 Li (B70) 2015; 112 Jaramillo (B96) 2016; 9 Roth (B103) 2016; 89 Chow (B56) 2014; 29 Layne (B107) 2022; 16 Knight (B142) 2023; 105 Linden (B69) 1995; 18 B122 Greer (B67) 2010; 140 Costales (B73) 2015; 12 García-González (B152) 2021; 48 Vazquez (B127) 2004; 24 Schwenk (B44) 2014; 84 Davidson (B80) 2023; 43 Delling (B52) 2021; 13 Verpelli (B51) 2014 Christensen (B135) 2013; 309 Kilinc (B121) 2018; 91 Halbedl (B99) 2016; 137 Banker (B48) 2021 Uchino (B54) 2006; 97 Nicolini (B61) 2018; 299 Jung (B62) 2008; 9 Serrada-Tejeda (B79) 2022; 181 Gill (B20) 2019; 13 Kanemura (B149) 2021; 170 Bech (B140) 2018; 89 Hamdan (B114) 2009; 360 Jimenez-Gomez (B109) 2019; 11 Gryder (B145) 2003; 23 Bozdagi (B55) 2010; 1 D’Mello (B45) 2015; 9 Aceti (B58) 2015; 77 Krapivinsky (B129) 2004; 43 Lyons-Warren (B123) 2022; 12 Mei (B102) 2016; 530 Wenthold (B43) 1996; 16 |
| References_xml | – volume: 64 year: 2023 ident: B148 article-title: Perampanel as precision therapy in rare genetic epilepsies publication-title: Epilepsia doi: 10.1111/epi.17530 contributor: fullname: Nissenkorn – volume: 13 year: 2022 ident: B74 article-title: “Variability in phelan-mcDermid syndrome in a cohort of 210 individuals,” publication-title: Front Genet doi: 10.3389/fgene.2022.652454 contributor: fullname: Nevado – volume: 38 year: 2015 ident: B32 article-title: Controlling cerebellar output to treat refractory epilepsy publication-title: Trends Neurosci doi: 10.1016/j.tins.2015.10.002 contributor: fullname: Kros – volume-title: Modeling the evolution of the cerebellum. From macroevolution to function year: 2014 ident: B17 contributor: fullname: Smaers – volume: 23 start-page: 1485 year: 2019 ident: B2 article-title: Early emergence of discrepancy in adaptive behavior and cognitive skills in toddlers with autism spectrum disorder publication-title: Autism doi: 10.1177/1362361318815662 contributor: fullname: Bradshaw – volume: 4 start-page: 9 year: 2013 ident: B105 article-title: Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay publication-title: Mol Autism doi: 10.1186/2040-2392-4-9 contributor: fullname: Bozdagi – volume: 15 year: 2021 ident: B112 article-title: “Phenotypes in children with SYNGAP1 encephalopathy in China,” publication-title: Front Neurosci doi: 10.3389/fnins.2021.761473 contributor: fullname: Zhang – volume: 13 year: 2014 ident: B47 article-title: Interaction proteomics reveals brain region-specific AMPA receptor complexes publication-title: J Proteome Res doi: 10.1021/pr500697b contributor: fullname: Chen – volume: 102 year: 2019 ident: B39 article-title: Universal transform or multiple functionality? Understanding the contribution of the human cerebellum across task domains publication-title: Neuron doi: 10.1016/j.neuron.2019.04.021 contributor: fullname: Diedrichsen – volume: 53 year: 2016 ident: B113 article-title: Genetic and neurodevelopmental spectrum of SYNGAP1-associated intellectual disability and epilepsy publication-title: J Med Genet doi: 10.1136/jmedgenet-2015-103451 contributor: fullname: Mignot – volume: 34 year: 2012 ident: B139 article-title: Preliminary findings of the developmental effects of in utero exposure to topiramate publication-title: Reprod Toxicol doi: 10.1016/j.reprotox.2012.05.038 contributor: fullname: Rihtman – volume: 57 year: 1998 ident: B28 article-title: Neuropathology of infantile autism publication-title: J Neuropathol Exp Neurol doi: 10.1097/00005072-199807000-00001 contributor: fullname: Kemper – volume: 10 year: 2023 ident: B130 article-title: Syngap1 disruption induced by recombination between inverted loxP sites is associated with hippocampal interneuron dysfunction publication-title: eNeuro doi: 10.1523/ENEURO.0475-22.2023 contributor: fullname: Khlaifia – volume: 167 start-page: 106452 year: 2020 ident: B144 article-title: Inhibitory effect of anti-seizure medications on ionotropic glutamate receptors: special focus on AMPA receptor subunits publication-title: Epilepsy Res doi: 10.1016/j.eplepsyres.2020.106452 contributor: fullname: Fukushima – start-page: 793 year: 2021 ident: B48 article-title: Hippocampal contributions to social and cognitive deficits in autism spectrum disorder publication-title: Trends Neurosci doi: 10.1016/j.tins.2021.08.005 contributor: fullname: Banker – volume: 25 start-page: 799 year: 2005 ident: B37 article-title: Number and density of AMPA receptors in single synapses in immature cerebellum publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4256-04.2005 contributor: fullname: Tanaka – start-page: 1 year: 2021 ident: B25 article-title: Abnormal cerebellar development in autism spectrum disorders publication-title: Dev Neurosci doi: 10.1159/000515189 contributor: fullname: Van Der Heijden – volume: 2 start-page: 1 year: 2011 ident: B71 article-title: Dendritic spine formation and synaptic function require neurobeachin publication-title: Nat Commun doi: 10.1038/ncomms1565 contributor: fullname: Niesmann – volume: 101 year: 2019 ident: B15 article-title: A synaptic perspective of fragile X syndrome and autism spectrum disorders publication-title: Neuron doi: 10.1016/j.neuron.2019.02.041 contributor: fullname: Bagni – volume: 31 start-page: 4956 year: 2021 ident: B86 article-title: SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling publication-title: Curr Biol doi: 10.1016/j.cub.2021.09.022 contributor: fullname: Salomaa – volume: 11 start-page: 18 year: 2019 ident: B109 article-title: Phenotypic characterization of individuals with SYNGAP1 pathogenic variants reveals a potential correlation between posterior dominant rhythm and developmental progression publication-title: J Neurodev Disord doi: 10.1186/s11689-019-9276-y contributor: fullname: Jimenez-Gomez – volume: 2 year: 1943 ident: B4 article-title: Autistic disturbances of affective contact publication-title: Nerv Child doi: 10.1111/fwb.12896 contributor: fullname: Kanner – volume: 10 year: 2016 ident: B59 article-title: SYNGAP1: mind the gap publication-title: Front Cell Neurosci doi: 10.3389/fncel.2016.00032 contributor: fullname: Jeyabalan – ident: B106 – volume: 86 year: 2015 ident: B22 article-title: “Mammalian brains are made of these: A dataset of the numbers and densities of neuronal and nonneuronal cells in the brain of glires, primates, scandentia, eulipotyphlans, afrotherians and artiodactyls, and their relationship with body mass,” publication-title: Brain Behav Evol doi: 10.1159/000437413 contributor: fullname: Herculano-Houzel – volume: 12 start-page: 900 year: 2012 ident: B120 article-title: SynGAP isoforms exert opposing effects on synaptic strength publication-title: Nat Commun doi: 10.1038/ncomms1900 contributor: fullname: McMahon – volume: 12 year: 2015 ident: B73 article-title: Phelan-mcDermid syndrome and SHANK3: implications for treatment publication-title: Neurotherapeutics doi: 10.1007/s13311-015-0352-z contributor: fullname: Costales – volume: 16 year: 2023 ident: B84 article-title: “Bridging the translational gap: what can synaptopathies tell us about autism?,” publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2023.1191323 contributor: fullname: Molloy – volume: 47 year: 2005 ident: B134 article-title: Characteristics of fetal anticonvulsant syndrome associated autistic disorder publication-title: Dev Med Child Neurol doi: 10.1017/S0012162205001076 contributor: fullname: Rasalam – volume: 9 year: 2015 ident: B45 article-title: “Cerebro-cerebellar circuits in autism spectrum disorder publication-title: Front Neurosci doi: 10.3389/fnins.2015.00408 contributor: fullname: D’Mello – volume: 26 year: 2021 ident: B98 article-title: Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice publication-title: Mol Psychiatry doi: 10.1038/s41380-021-01230-x contributor: fullname: Moutin – volume: 181 year: 2022 ident: B79 article-title: Sensory processing and adaptive behavior in Phelan-McDermid syndrome: a cross-sectional study publication-title: Eur J Pediatr doi: 10.1007/s00431-022-04564-y contributor: fullname: Serrada-Tejeda – volume: 24 year: 2004 ident: B127 article-title: SynGAP regulates spine formation publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3213-04.2004 contributor: fullname: Vazquez – volume: 13 year: 2019 ident: B3 article-title: “Genetic causes and modifiers of autism spectrum disorder,” publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00385 contributor: fullname: Rylaarsdam – volume: 43 year: 2023 ident: B80 article-title: Gastrointestinal dysfunction in genetically defined neurodevelopmental disorders publication-title: Semin Neurol doi: 10.1055/s-0043-1771460 contributor: fullname: Davidson – volume: 10 start-page: 1 year: 2021 ident: B41 article-title: Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons publication-title: Elife doi: 10.7554/eLife.68045 contributor: fullname: van der Heijden – volume: 26 year: 2021 ident: B97 article-title: Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex publication-title: Mol Psychiatry doi: 10.1038/s41380-021-01023-2 contributor: fullname: Chiola – volume: 105 start-page: 56 year: 2023 ident: B142 article-title: Adaptive behaviour in children exposed to topiramate in the womb: An observational cohort study publication-title: Seizure doi: 10.1016/j.seizure.2023.01.008 contributor: fullname: Knight – volume: 14 year: 2023 ident: B147 article-title: Case report: Off-label use of low-dose perampanel in a 25-month-old girl with a pathogenic SYNGAP1 variant publication-title: Front Neurol doi: 10.3389/fneur.2023.1221161 contributor: fullname: Gupta – volume: 9 year: 2008 ident: B62 article-title: Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway publication-title: BMC Cell Biol doi: 10.1186/1471-2121-9-66 contributor: fullname: Jung – volume: 96 year: 2017 ident: B13 article-title: Prenatal, perinatal, and postnatal factors associated with autism publication-title: Med (Baltimore) doi: 10.1097/MD.0000000000006696 contributor: fullname: Wang – volume: 10 year: 2020 ident: B141 article-title: “Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study,” publication-title: BMJ Open doi: 10.1136/bmjopen-2019-034829 contributor: fullname: Blotière – volume: 13 year: 2013 ident: B72 article-title: An EJC factor RBM8a regulates anxiety behaviors publication-title: Curr Mol Med doi: 10.2174/15665240113139990019 contributor: fullname: Alachkar – volume: 78 year: 2015 ident: B34 article-title: Cerebro-cerebellar resting-state functional connectivity in children and adolescents with autism spectrum disorder publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2015.03.024 contributor: fullname: Khan – volume: 91 year: 2018 ident: B121 article-title: Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders publication-title: Mol Cell Neurosci doi: 10.1016/j.mcn.2018.03.008 contributor: fullname: Kilinc – volume: 16 start-page: 1 year: 2022 ident: B92 article-title: The role of zinc and NMDA receptors in autism spectrum disorders publication-title: Pharm (Basel) doi: 10.3390/ph16010001 contributor: fullname: Lee – volume: 5 year: 2004 ident: B132 article-title: The neurobiology of antiepileptic drugs publication-title: Nat Rev Neurosci 2004 57 doi: 10.1038/nrn1430 contributor: fullname: Rogawski – volume: 83 year: 2014 ident: B1 article-title: The cerebellum, sensitive periods, and autism publication-title: Neuron doi: 10.1016/j.neuron.2014.07.016 contributor: fullname: Wang – volume: 151 year: 2012 ident: B126 article-title: Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses publication-title: Cell doi: 10.1016/j.cell.2012.08.045 contributor: fullname: Clement – volume: 1 year: 2010 ident: B55 article-title: Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication publication-title: Mol Autism doi: 10.1186/2040-2392-1-15 contributor: fullname: Bozdagi – volume: 89 year: 2016 ident: B103 article-title: DREADDs for neuroscientists publication-title: Neuron doi: 10.1016/j.neuron.2016.01.040 contributor: fullname: Roth – volume: 12 year: 2019 ident: B60 article-title: Differential regulation of syngap1 translation by FMRP modulates eEF2 mediated response on NMDAR activity publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2019.00097 contributor: fullname: Paul – volume: 176 year: 2018 ident: B77 article-title: Genotype and phenotype correlations for SHANK3 de novo mutations in neurodevelopmental disorders publication-title: Am J Med Genet A doi: 10.1002/ajmg.a.40666 contributor: fullname: Li – volume: 31 start-page: 17 year: 1995 ident: B40 article-title: “Distribution of AMPA-selective glutamate receptor subunits in the human hippocampus and cerebellum,” publication-title: Mol Brain Res doi: 10.1016/0169-328X(95)00021-J contributor: fullname: Day – volume: 809 start-page: 137305 year: 2023 ident: B101 article-title: GluA1-Shank3 interaction decreases in response to chronic neuronal depolarization publication-title: Neurosci Lett doi: 10.1016/j.neulet.2023.137305 contributor: fullname: Ross – volume: 13 start-page: 1 year: 2019 ident: B20 article-title: “Functional outcomes of cerebellar malformations,” publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00441 contributor: fullname: Gill – volume: 462 start-page: 4 year: 2021 ident: B42 article-title: Interactions between purkinje cells and granule cells coordinate the development of functional cerebellar circuits publication-title: Neuroscience doi: 10.1016/j.neuroscience.2020.06.010 contributor: fullname: van der Heijden – volume: 2 year: 2003 ident: B14 article-title: Model of autism: increased ratio of excitation/inhibition in key neural systems publication-title: Genes Brain Behav doi: 10.1034/j.1601-183X.2003.00037.x contributor: fullname: Rubenstein – volume: 266 year: 1977 ident: B68 article-title: Heterosynaptic depression: a postsynaptic correlate of long-term potentiation publication-title: Nature doi: 10.1038/266737a0 contributor: fullname: Lynch – volume: 15 year: 2022 ident: B8 article-title: Global prevalence of autism: A systematic review update publication-title: Autism Res doi: 10.1002/aur.2696 contributor: fullname: Zeidan – volume: 329 year: 2023 ident: B10 article-title: Autism spectrum disorder: A review publication-title: JAMA doi: 10.1001/jama.2022.23661 contributor: fullname: Hirota – volume: 309 year: 2013 ident: B135 article-title: Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism publication-title: JAMA doi: 10.1001/jama.2013.2270 contributor: fullname: Christensen – volume: 61 year: 2023 ident: B63 article-title: Transcriptome analysis and epigenetics regulation in the hippocampus and the prefrontal cortex of VPA-induced rat model publication-title: Mol Neurobiol doi: 10.1007/s12035-023-03560-z contributor: fullname: Chen – volume: 232 year: 1973 ident: B66 article-title: Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path publication-title: J Physiol doi: 10.1113/jphysiol.1973.sp010273 contributor: fullname: Bliss – volume: 120 year: 2007 ident: B26 article-title: Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors publication-title: Pediatrics doi: 10.1542/peds.2007-1041 contributor: fullname: Limperopoulos – volume: 22 year: 2019 ident: B93 article-title: Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice publication-title: Nat Neurosci doi: 10.1038/s41593-019-0445-9 contributor: fullname: Guo – volume: 65 year: 2023 ident: B136 article-title: “Valproate use associated with frontal and cerebellar grey matter volume reductions: a voxel-based morphometry study,” publication-title: Epilepsia doi: 10.1111/epi.17825 contributor: fullname: Shin – volume: 44 year: 2018 ident: B138 article-title: Pharmacological modulation of AMPA receptor rescues social impairments in animal models of autism publication-title: Neuropsychopharmacol 2018 442 contributor: fullname: Kim – volume: 10 year: 2018 ident: B57 article-title: The first international conference on SYNGAP1-related brain disorders: a stakeholder meeting of families, researchers, clinicians, and regulators publication-title: J Neurodev Disord doi: 10.1186/s11689-018-9225-1 contributor: fullname: Weldon – volume: 170 start-page: 106550 year: 2021 ident: B149 article-title: Efficacy of perampanel in epilepsy patients with autism spectrum disorder publication-title: Epilepsy Res doi: 10.1016/j.eplepsyres.2021.106550 contributor: fullname: Kanemura – volume: 87 year: 2020 ident: B150 article-title: Low-dose perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron gluA2 upregulation in epileptic syngap1+/– mice publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2019.12.025 contributor: fullname: Sullivan – volume: 1262 start-page: 48 year: 2009 ident: B35 article-title: Aberrant functional connectivity in autism: Evidence from low-frequency BOLD signal fluctuations publication-title: Brain Res doi: 10.1016/j.brainres.2008.12.076 contributor: fullname: Noonan – volume: 21 start-page: 254 year: 2023 ident: B87 article-title: Expression profiles of the autism-related SHANK proteins in the human brain publication-title: BMC Biol doi: 10.1186/s12915-023-01712-0 contributor: fullname: Woelfle – volume: 16 year: 2022 ident: B107 article-title: “Comparison of treadmill gait between a pediatric-aged individual with SYNGAP1-related intellectual disability and a fraternal twin,” publication-title: Front Hum Neurosci doi: 10.3389/fnhum.2022.918918 contributor: fullname: Layne – volume: 77 year: 2015 ident: B58 article-title: Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2014.08.001 contributor: fullname: Aceti – volume: 105 year: 1981 ident: B30 article-title: Crossed cerebellar diaschisis in human supratentorial brain infarction publication-title: Trans Am Neurol Assoc contributor: fullname: Baron – volume: 112 year: 2015 ident: B70 article-title: Synaptic P-rex1 signaling regulates hippocampal long-term depression and autism-like social behavior publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.1512913112 contributor: fullname: Li – volume: 92 year: 2016 ident: B78 article-title: SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons publication-title: Neuron doi: 10.1016/j.neuron.2016.11.007 contributor: fullname: Han – volume: 48 start-page: 89 year: 2021 ident: B152 article-title: Transcranial direct current stimulation in Autism Spectrum Disorder: A systematic review and meta-analysis publication-title: Eur Neuropsychopharmacol doi: 10.1016/j.euroneuro.2021.02.017 contributor: fullname: García-González – volume: 16 year: 1996 ident: B43 article-title: “Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons publication-title: J Neurosci doi: 10.1523/JNEUROSCI.16-06-01982.1996 contributor: fullname: Wenthold – volume: 15 start-page: 1 year: 2021 ident: B88 article-title: “Common and distinct disruptions of cortical surface morphology between autism spectrum disorder children with and without SHANK3 deficiency,” publication-title: Front Neurosci doi: 10.3389/fnins.2021.751364 contributor: fullname: Li – volume: 89 year: 2018 ident: B140 article-title: In utero exposure to antiepileptic drugs is associated with learning disabilities among offspring publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2018-318386 contributor: fullname: Bech – volume: 360 start-page: 599 year: 2009 ident: B114 article-title: Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation publication-title: N Engl J Med doi: 10.1056/NEJMoa0805392 contributor: fullname: Hamdan – volume: 38 start-page: 81 year: 2017 ident: B5 article-title: The changing epidemiology of autism spectrum disorders publication-title: Annu Rev Public Health doi: 10.1146/annurev-publhealth-031816-044318 contributor: fullname: Lyall – volume: 33 year: 2013 ident: B124 article-title: SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0765-13.2013 contributor: fullname: Clement – volume: 43 year: 2004 ident: B129 article-title: SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor- dependent synaptic AMPA receptor potentiation publication-title: Neuron doi: 10.1016/j.neuron.2004.08.003 contributor: fullname: Krapivinsky – volume: 79 year: 2022 ident: B131 article-title: Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability publication-title: JAMA Neurol doi: 10.1001/JAMANEUROL.2022.1269 contributor: fullname: Bjørk – volume: 71 year: 2008 ident: B133 article-title: Autism spectrum disorders following in utero exposure to antiepileptic drugs publication-title: Neurology doi: 10.1212/01.wnl.0000339399.64213.1a contributor: fullname: Bromley – volume: 121 start-page: 889 year: 1998 ident: B27 article-title: A clinicopathological study of autism publication-title: Brain doi: 10.1093/brain/121.5.889 contributor: fullname: Bailey – volume: 392 year: 2018 ident: B6 article-title: Autism spectrum disorder publication-title: Lancet (London England) doi: 10.1016/S0140-6736(18)31129-2 contributor: fullname: Lord – volume: 72 start-page: 1 year: 2023 ident: B7 article-title: Prevalence and characteristics of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2020 publication-title: MMWR Surveill Summ doi: 10.15585/mmwr.ss7202a1 contributor: fullname: Maenner – volume: 29 year: 2014 ident: B56 article-title: The potential role of insulin on the shank-postsynaptic platform in neurodegenerative diseases involving cognition publication-title: Am J Alzheimers Dis Other Demen doi: 10.1177/1533317513518645 contributor: fullname: Chow – volume: 191 year: 2023 ident: B81 article-title: Updated consensus guidelines on the management of Phelan-McDermid syndrome publication-title: Am J Med Genet A doi: 10.1002/AJMG.A.63312 contributor: fullname: Srivastava – volume: 103 year: 2006 ident: B118 article-title: SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0600084103 contributor: fullname: Rumbaugh – volume: 107 year: 2023 ident: B143 article-title: Neurodevelopmental disorders after prenatal exposure to topiramate: A lost decade idly watching from the sidelines publication-title: Seizure doi: 10.1016/j.seizure.2023.03.009 contributor: fullname: Braillon – volume: 140 year: 2010 ident: B67 article-title: The angelman syndrome protein ube3A regulates synapse development by ubiquitinating arc publication-title: Cell doi: 10.1016/j.cell.2010.01.026 contributor: fullname: Greer – volume: 13 year: 2021 ident: B52 article-title: Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications publication-title: J Neurodev Disord doi: 10.1186/s11689-021-09397-8 contributor: fullname: Delling – volume: 40 year: 2020 ident: B128 article-title: SYNGAP1 controls the maturation of dendrites, synaptic function, and network activity in developing human neurons publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1367-20.2020 contributor: fullname: Llamosas – volume: 530 year: 2016 ident: B102 article-title: Adult restoration of Shank3 expression rescues selective autistic-like phenotypes publication-title: Nature doi: 10.1038/nature16971 contributor: fullname: Mei – volume: 177 year: 2023 ident: B12 article-title: Persistence of autism spectrum disorder from early childhood through school age publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2023.4003 contributor: fullname: Harstad – volume: 14 year: 2023 ident: B146 article-title: The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy publication-title: Front Neurol doi: 10.3389/fneur.2023.1182304 contributor: fullname: Perversi – volume: 60 year: 2019 ident: B33 article-title: Cerebellar, limbic, and midbrain volume alterations in sudden unexpected death in epilepsy publication-title: Epilepsia doi: 10.1111/epi.14689 contributor: fullname: Allen – volume: 10 start-page: 294 year: 2020 ident: B76 article-title: Deep phenotyping of development, communication and behaviour in phelan-mcDermid syndrome publication-title: Mol Syndromol doi: 10.1159/000503840 contributor: fullname: Droogmans – volume: 9 start-page: 1 year: 2019 ident: B137 article-title: Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism publication-title: Sci Rep doi: 10.1038/s41598-019-45667-1 contributor: fullname: Spisák – volume: 17 start-page: 24 year: 2019 ident: B104 article-title: Chemogenetic activation of prefrontal cortex in shank3-deficient mice ameliorates social deficits, NMDAR hypofunction, and sgk2 downregulation publication-title: iScience doi: 10.1016/j.isci.2019.06.014 contributor: fullname: Qin – volume: 24 year: 2014 ident: B21 article-title: Rapid evolution of the cerebellum in humans and other great apes publication-title: Curr Biol doi: 10.1016/j.cub.2014.08.056 contributor: fullname: Barton – volume: 4 start-page: 1 year: 2010 ident: B19 article-title: “Coordinated scaling of cortical and cerebellar numbers of neurons,” publication-title: Front Neuroanat doi: 10.3389/fnana.2010.00012 contributor: fullname: Herculano-Houzel – volume: 28 start-page: 91 year: 2015 ident: B16 article-title: Autism and the synapse: emerging mechanisms and mechanism-based therapies publication-title: Curr Opin Neurol doi: 10.1097/WCO.0000000000000186 contributor: fullname: Ebrahimi-Fakhari – volume: 9 year: 2015 ident: B24 article-title: Cerebro-cerebellar circuits in autism spectrum disorder publication-title: Front Neurosci doi: 10.3389/FNINS.2015.00408 contributor: fullname: D’Mello – volume: 13 year: 2021 ident: B85 article-title: Expression of the excitatory postsynaptic scaffolding protein, shank3, in human brain: effect of age and alzheimer’s disease publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2021.717263 contributor: fullname: Wan – ident: B122 – volume: 479 year: 2021 ident: B50 article-title: The potential role of AMPA receptor trafficking in autism and other neurodevelopmental conditions publication-title: Neuroscience doi: 10.1016/j.neuroscience.2021.09.013 contributor: fullname: Niescier – volume: 137 start-page: 26 year: 2016 ident: B99 article-title: Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals publication-title: J Neurochem doi: 10.1111/jnc.13523 contributor: fullname: Halbedl – volume: 66 start-page: 104746 year: 2023 ident: B82 article-title: Consensus recommendations on Epilepsy in Phelan-McDermid syndrome publication-title: Eur J Med Genet doi: 10.1016/j.ejmg.2023.104746 contributor: fullname: de Coo – volume: 2 year: 2005 ident: B29 article-title: The cerebellum in autism publication-title: Clin Neuropsychiatry doi: 10.1093/acprof:oso/9780195182224.003.0003 contributor: fullname: Allen – volume: 84 start-page: 41 year: 2014 ident: B44 article-title: Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain publication-title: Neuron doi: 10.1016/j.neuron.2014.08.044 contributor: fullname: Schwenk – volume: 85 year: 2015 ident: B116 article-title: Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP publication-title: Neuron doi: 10.1016/j.neuron.2014.12.023 contributor: fullname: Araki – volume: 27 start-page: 2328 year: 2019 ident: B49 article-title: Cerebellar lobulus simplex and crus I differentially represent phase and phase difference of prefrontal cortical and hippocampal oscillations article cerebellar lobulus simplex and crus I differentially represent phase and phase difference of prefrontal C publication-title: Cell Rep doi: 10.1016/j.celrep.2019.04.085 contributor: fullname: Mcafee – volume: 39 year: 2019 ident: B89 article-title: Deletion of autism risk gene shank3 disrupts prefrontal connectivity publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2529-18.2019 contributor: fullname: Pagani – volume: 9 year: 2016 ident: B96 article-title: Altered striatal synaptic function and abnormal behaviour in shank3 exon4-9 deletion mouse model of autism publication-title: Autism Res doi: 10.1002/aur.1529 contributor: fullname: Jaramillo – volume: 92 start-page: E96 year: 2019 ident: B110 article-title: “SYNGAP1 encephalopathy: A distinctive generalized developmental and epileptic encephalopathy,” publication-title: Neurology doi: 10.1212/WNL.0000000000006729 contributor: fullname: Vlaskamp – volume: 118 year: 2021 ident: B119 article-title: Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.2100579118 contributor: fullname: Llamosas – volume: 93 year: 2017 ident: B65 article-title: A brief history of long-term potentiation publication-title: Neuron doi: 10.1016/j.neuron.2016.12.015 contributor: fullname: Nicoll – volume: 8 year: 2013 ident: B115 article-title: SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks publication-title: PloS One doi: 10.1371/journal.pone.0083941 contributor: fullname: Wang – volume-title: Cerebellar granule cell,” in handbook of the cerebellum and cerebellar disorders year: 2021 ident: B36 contributor: fullname: D’Angelo – volume: 7 start-page: 1 year: 2018 ident: B18 article-title: A cerebellar substrate for cognition evolved multiple times independently in mammals publication-title: Elife doi: 10.7554/eLife.35696 contributor: fullname: Smaers – volume: 97 year: 2006 ident: B54 article-title: Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.03831.x contributor: fullname: Uchino – volume: 12 start-page: 137 year: 2022 ident: B123 article-title: Sensory processing phenotypes in phelan-mcDermid syndrome and SYNGAP1-related intellectual disability publication-title: Brain Sci doi: 10.3390/brainsci12020137 contributor: fullname: Lyons-Warren – volume: 16 year: 2021 ident: B108 article-title: New genes involved in Angelman syndrome-like: Expanding the genetic spectrum publication-title: PloS One doi: 10.1371/journal.pone.0258766 contributor: fullname: Aguilera – volume: 47 year: 2022 ident: B117 article-title: Rho-rho-kinase regulates ras-ERK signaling through synGAP1 for dendritic spine morphology publication-title: Neurochem Res doi: 10.1007/s11064-022-03623-y contributor: fullname: Wu – volume: 97 year: 2002 ident: B23 article-title: A universal scaling law between gray matter and white matter of cerebral cortex publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.090504197 contributor: fullname: Zhang – volume: 180 start-page: 568 year: 2020 ident: B83 article-title: “Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism publication-title: Cell doi: 10.1016/j.cell.2019.12.036 contributor: fullname: Satterstrom – volume: 8 start-page: 84 year: 2018 ident: B95 article-title: Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors publication-title: Transl Psychiatry doi: 10.1038/s41398-018-0142-6 contributor: fullname: Bey – volume: 7 year: 2005 ident: B31 article-title: Cerebellar atrophy in temporal lobe epilepsy publication-title: Epilepsy Behav doi: 10.1016/j.yebeh.2005.05.022 contributor: fullname: Hermann – volume: 29 year: 2004 ident: B64 article-title: Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons publication-title: Neurochem Res doi: 10.1023/B:NERE.0000010456.92887.3b contributor: fullname: Poulsen – volume: 106 year: 2011 ident: B38 article-title: The organization of the human cerebellum estimated by intrinsic functional connectivity publication-title: J Neurophysiol doi: 10.1152/jn.00339.2011 contributor: fullname: Buckner – ident: B75 – volume: 11 start-page: 1 year: 2022 ident: B151 article-title: Cerebellar transcranial direct current stimulation in children with autism spectrum disorder: A pilot study on efficacy, feasibility, safety, and unexpected outcomes in tic disorder and epilepsy publication-title: J Clin Med contributor: fullname: D’urso – volume: 90 start-page: 37 year: 2019 ident: B90 article-title: Volumetric analysis of the basal ganglia and cerebellar structures in patients with phelan-mcDermid syndrome publication-title: Pediatr Neurol doi: 10.1016/j.pediatrneurol.2018.09.008 contributor: fullname: Srivastava – volume: 132 year: 2021 ident: B111 article-title: SYNGAP1-DEE: A visual sensitive epilepsy publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2021.01.014 contributor: fullname: Lo Barco – volume: 299 year: 2018 ident: B61 article-title: “The valproic acid-induced rodent model of autism,” publication-title: Exp Neurol doi: 10.1016/j.expneurol.2017.04.017 contributor: fullname: Nicolini – volume: 161 year: 2013 ident: B91 article-title: Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion publication-title: Am J Med Genet Part A doi: 10.1002/ajmg.a.35700 contributor: fullname: Aldinger – volume: 51 year: 2021 ident: B9 article-title: The diagnosis of autism: from kanner to DSM-III to DSM-5 and beyond publication-title: J Autism Dev Disord doi: 10.1007/s10803-021-04904-1 contributor: fullname: Rosen – year: 2014 ident: B51 article-title: “Structural and functional organization of the postsynaptic density,” publication-title: Synap Struct Funct doi: 10.1016/B978-0-12-418675-0.00004-3 contributor: fullname: Verpelli – volume: 18 year: 2017 ident: B53 article-title: SHANK proteins: roles at the synapse and in autism spectrum disorder publication-title: Nat Rev Neurosci doi: 10.1038/nrn.2016.183 contributor: fullname: Monteiro – volume: 57 year: 2001 ident: B46 article-title: Postmortem brain abnormalities of the glutamate neurotransmitter system in autism publication-title: Neurology doi: 10.1212/WNL.57.9.1618 contributor: fullname: Purcell – volume: 18 year: 1995 ident: B69 article-title: Long-term synaptic depression publication-title: Annu Rev Neurosci doi: 10.1146/annurev.ne.18.030195.001535 contributor: fullname: Linden – volume: 33 year: 2013 ident: B100 article-title: Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2725-12.2013 contributor: fullname: Raynaud – volume: 23 year: 2003 ident: B145 article-title: Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-18-07069.2003 contributor: fullname: Gryder – volume: 82 year: 2014 ident: B125 article-title: Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons publication-title: Neuron doi: 10.1016/j.neuron.2014.05.015 contributor: fullname: Ozkan – volume: 16 year: 2023 ident: B11 article-title: Autism severity and its relationship to disability publication-title: Autism Res doi: 10.1002/aur.2898 contributor: fullname: Waizbard-Bartov – volume: 12 year: 2013 ident: B153 article-title: Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence publication-title: Lancet Neurol doi: 10.1016/S1474-4422(13)70011-5 contributor: fullname: Moreno-De-Luca – volume: 127 year: 2017 ident: B94 article-title: Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism publication-title: J Clin Invest doi: 10.1172/JCI87997 contributor: fullname: Wang |
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