Is one-size-fits-all strategy adequate for platelet storage?

• Published in: Transfusion and apheresis science Vol. 55; no. 3; pp. 323 - 328
• Main Authors: Eker, Ibrahim, Yilmaz, Soner, Cetinkaya, Rıza Aytac, Unlu, Aytekin, Pekel, Aysel, Acikel, Cengizhan, Yilmaz, Sebahattin, Gursel, Orhan, Avci, İsmail Yaşar
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-12-2016
• Subjects: Antigens, CD - metabolism; Blood Component Removal; Blood Platelets - cytology; Blood Preservation - methods; Cell Survival; Health technology assessment; Hematology, Oncology and Palliative Medicine; Hemostasis; Humans; Male; Platelets; Storage temperature; Trauma; Platelets; Hemostasis; Trauma; Storage Temperature; Storage temperature
• ISSN: 1473-0502; 1878-1683
• DOI: 10.1016/j.transci.2016.08.006

Abstract Background Platelet suspensions (PSs) are stored at room temperature. However, recent reports show that PS stored at 4°C possess superior hemostatic properties. We compared the viabilities and thrombin generation capacities of PSs stored either at 4°C or 22°C hours. Materials and Methods Twenty units of apheresis derived platelets (ADPs) from 20 male donors and 20 units of random platelet suspensions (RPSs) from another 20 male donors were obtained. Half of the ADPs and half of the RPSs (10 units/per group) were stored at 4°C, the other halves of ADPs and RPSs (10 units/per group) were stored in agitators, at 22°C for 48 hours. The flow cytometric viability tests and thrombin generation tests of the PSs were assessed. Results The viabilities of both ADPs and RPSs group platelets, stored either at 4°C or 22°C for 48 hours, were not statistically significantly different. The ADPs and RPSs stored at 4°C generated significantly higher peak thrombin levels than the platelets stored at 22°C. Moreover, the ADPs group stored at 4°C showed significantly shorter time to thrombin generation and reach peak levels. Conclusion The PSs stored at 4°C showed higher and faster thrombin generation capacities than the room temperature PSs. Given the superior hemostatic properties of refrigerated platelets, creating different storage temperature capabilities for specific transfusion purposes may be a prudent approach, especially for improving the outcome of bleeding trauma casualties.