A death-domain-containing receptor that mediates apoptosis

The cell-killing effects of the cytokines TNF-alpha and FasL are mediated by the distinct cell-surface receptors TNFR1, TNFR2 and Fas (also known as CD95/APO-1), which are all members of a receptor superfamily that is important for regulating cell survival. The cytoplasmic regions of TNFR1 and Fas c...

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Bibliographic Details
Published in:	Nature (London) Vol. 384; no. 6607; pp. 372 - 375
Main Authors:	Kitson, Jeremy, Raven, Thomas, Jiang, Ying-Ping, Goeddel, David V, Giles, Katharine M, Pun, Kwok-Tao, Grinham, Christine J, Brown, Robin, Farrow, Stuart N
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 28-11-1996 Nature Publishing Group
Subjects:	Ageing, cell death Amino Acid Sequence Antigens, CD - chemistry Apoptosis Biological and medical sciences Cell Line Cell physiology Cloning, Molecular Conserved Sequence Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular Sequence Data Mortality Mutagenesis Protein Binding Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor, Member 25 Receptors, Tumor Necrosis Factor, Type I Sequence Homology, Amino Acid Signal Transduction Transfection Yeasts Human Nucleotide sequence Tissue specificity Homology Gene expression Binding protein Signal transduction Cell line Complementary DNA Gene Domain structure Tumor necrosis factor Multigene family Apoptosis Biological receptor
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