Lack of evidence for the efficacy of enhanced surveillance compared to other specific interventions to control neonatal healthcare-associated infection outbreaks

• Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 110; no. 2; pp. 98 - 106
• Main Authors: Birt, J., Le Doare, K., Kortsalioudaki, C., Lawn, J., Heath, P. T., Sharland, M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01-02-2016
• Subjects: Cross Infection - epidemiology; Cross Infection - prevention & control; Cross Infection - transmission; Disease Outbreaks - prevention & control; Evidence-Based Practice; Humans; Infant; Infant, Newborn; Intensive Care Units, Neonatal; Sentinel Surveillance; Systematic Review; Prevention; Neonates; Outbreaks; Hospital-acquired infection
• ISSN: 0035-9203; 1878-3503
• DOI: 10.1093/trstmh/trv116

Background
Despite current prevention efforts, outbreaks of healthcare-associated infections in neonatal units remain high globally, with a considerable burden of mortality and morbidity.
Methods
We searched Medline, Cochrane Library and Outbreak database to identify studies of neonatal healthcare-associated outbreaks between 2005 and 2015 that described interventions to control outbreaks. All studies were evaluated using the ORION guidance.
Results
Thirty studies were identified including 17 102 infants of whom 664 (3.9%) became infected. No single intervention was identified that reduced duration or mortality. Studies that introduced multiple interventions had significantly reduced case fatality ratio and outbreak duration compared to those that used basic surveillance only. Low and low-middle income countries reported the fewest interventions to control outbreaks and these studies were also associated with higher mortality than that found in middle and high income countries.
Conclusions
Systematic reporting and formal evaluation of interventions used to reduce healthcare-associated neonatal infection outbreaks is key to identifying containment strategies worldwide.