Effects of preoperative radiotherapy for primary resectable rectal adenocarcinoma on male sexual and urinary function

• Published in: Diseases of the colon & rectum Vol. 45; no. 7; p. 934
• Main Authors: Bonnel, Catherine, Parc, Yann R, Pocard, Marc, Dehni, Nidal, Caplin, Scott, Parc, Rolland, Tiret, Emmanuel
• Format: Journal Article
• Language: English
• Published: United States 01-07-2002
• Subjects: Adenocarcinoma - radiotherapy; Adenocarcinoma - surgery; Aged; Colectomy - methods; Humans; Male; Middle Aged; Preoperative Care; Radiotherapy, Adjuvant; Rectal Neoplasms - radiotherapy; Rectal Neoplasms - surgery; Retrospective Studies; Sexual Behavior - radiation effects; Treatment Outcome; Urination - radiation effects
• ISSN: 0012-3706
• DOI: 10.1007/s10350-004-6332-8

The purpose of this study was to determine whether preoperative radiotherapy had an influence on the urinary and sexual function of patients having a sphincter-saving, nerve-preserving total mesorectal excision.
Urinary and sexual function of male patients undergoing sphincter-saving, nerve-preserving total mesorectal excision for primary resectable rectal carcinoma between January 1998 and December 1999 were evaluated retrospectively. Assessment was by standardized questionnaires.
Fifty male patients met the inclusion criteria. Three patients had died (hepatic metastases), and five were living outside the European community and could not be contacted. Sixteen patients underwent preoperative radiotherapy (Group 1), and 26 patients were not treated preoperatively (Group 2). There was no perioperative mortality. Age, tumor stage, and localization of the tumor were comparable. Median follow-up was 20 months. Urinary function was not significantly different. One patient in Group 1 and 2 patients in Group 2 were impotent before surgery. All remaining patients in Group 2 (n = 24) and 11 of 15 remaining patients in Group 1 were sexually active (P = 0.016). All sexually active patients (n = 24) in Group 2 and 9 of the 11 sexually active patients in Group 1 have normal ejaculation (P = 0.09).
Preoperative radiotherapy for primary resectable rectal carcinoma treated by total mesorectal excision with autonomic nerve preservation may impair male sexual function.