A Nosocomial Outbreak of Fluoroquinolone-Resistant Streptococcus pneumoniae
Over the course of a 20-month period, in a hospital respiratory ward in which ciprofloxacin was often used as empirical antimicrobial therapy for lower respiratory tract infections (LRTIs), 16 patients with chronic bronchitis developed nosocomial LRTIs caused by penicillin- and ciprofloxacin-resista...
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Published in: | Clinical infectious diseases Vol. 33; no. 4; pp. 517 - 522 |
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Main Authors: | , , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Chicago, IL
The University of Chicago Press
15-08-2001
University of Chicago Press |
Subjects: | |
Online Access: | Get full text |
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Summary: | Over the course of a 20-month period, in a hospital respiratory ward in which ciprofloxacin was often used as empirical antimicrobial therapy for lower respiratory tract infections (LRTIs), 16 patients with chronic bronchitis developed nosocomial LRTIs caused by penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae (serotype 23 F). The minimum inhibitory concentration (MIC) of ciprofloxacin for all isolates from the first 9 patients was 4 µg/mL, in association with a parC mutation. Isolates from the subsequent 7 patients all had a ciprofloxacin MIC of 16 µg/mL, in association with an additional mutation in gyrA. The MICs for this isolate were 8 µg/mL of levofloxacin (resistant), 2 µg/mL of moxifloxacin and gatifloxacin (intermediately resistant), and 0.12 µg/mL of gemifloxacin. This outbreak demonstrates the ability of S. pneumoniae to acquire multiple mutations that result in increasing levels of resistance to the fluoroquinolones and to be transmitted from person to person. |
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Bibliography: | ark:/67375/HXZ-K9PBJKSP-V istex:7FDA9A543A5D1B7E43E4F17D593992F5F9AD93FF ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1086/322658 |