Protective Effect of Sufentanil on Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting Endoplasmic Reticulum Stress
Objective. Sufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective mechanism of sufentanil on rat myocardial ischemia-reperfusion (I/R) injury. Methods. A rat I/R model was established by ligating the left anter...
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| Published in: | Computational and mathematical methods in medicine Vol. 2022; pp. 6267720 - 8 |
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| Abstract | Objective. Sufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective mechanism of sufentanil on rat myocardial ischemia-reperfusion (I/R) injury. Methods. A rat I/R model was established by ligating the left anterior descending coronary artery. A total of 24 SD male rats were enrolled and divided randomly into the control group, I/R group, sufentanil group (SUF; 3 μg/kg), and diltiazem group (DLZ; 20 mg/kg; positive control). The rat hearts were subjected to 30 min of ischemia followed by 120 min of reperfusion. Subsequently, hemodynamics, pathological changes of myocardial tissue, serum biochemical parameters, oxidative stress factors, the level of serum inducible nitric oxide synthases (iNOS), interleukin-6 (IL-6), and other bioactive factors were analyzed in the rats. Result. Compared with the I/R group, sufentanil significantly improved cardiac action, myocardial fiber, and cardiomyocyte morphology and reduced inflammatory cell infiltration in rats in the SUF group. And the level of creatine kinase isoenzyme (CK-MB), troponin (cTn), lactate dehydrogenase (LDH), malondialdehyde (MDA), iNOS, and IL-6 was significantly declined in the serum of SUF group, while the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly activated in the myocardial tissues. In addition, sufentanil also significantly decreased the protein expression of GRP78, CHOP, Caspase 12, and ATF6 in the myocardial tissue of the SUF group. Conclusion. Sufentanil has a significant protective activity on myocardial I/R injury in rats, the mechanism of which may be associated with the inhibition of endoplasmic reticulum stress and oxidative stress. |
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| AbstractList | Objective. Sufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective mechanism of sufentanil on rat myocardial ischemia-reperfusion (I/R) injury. Methods. A rat I/R model was established by ligating the left anterior descending coronary artery. A total of 24 SD male rats were enrolled and divided randomly into the control group, I/R group, sufentanil group (SUF; 3 μg/kg), and diltiazem group (DLZ; 20 mg/kg; positive control). The rat hearts were subjected to 30 min of ischemia followed by 120 min of reperfusion. Subsequently, hemodynamics, pathological changes of myocardial tissue, serum biochemical parameters, oxidative stress factors, the level of serum inducible nitric oxide synthases (iNOS), interleukin-6 (IL-6), and other bioactive factors were analyzed in the rats. Result. Compared with the I/R group, sufentanil significantly improved cardiac action, myocardial fiber, and cardiomyocyte morphology and reduced inflammatory cell infiltration in rats in the SUF group. And the level of creatine kinase isoenzyme (CK-MB), troponin (cTn), lactate dehydrogenase (LDH), malondialdehyde (MDA), iNOS, and IL-6 was significantly declined in the serum of SUF group, while the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly activated in the myocardial tissues. In addition, sufentanil also significantly decreased the protein expression of GRP78, CHOP, Caspase 12, and ATF6 in the myocardial tissue of the SUF group. Conclusion. Sufentanil has a significant protective activity on myocardial I/R injury in rats, the mechanism of which may be associated with the inhibition of endoplasmic reticulum stress and oxidative stress. Sufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective mechanism of sufentanil on rat myocardial ischemia-reperfusion (I/R) injury. A rat I/R model was established by ligating the left anterior descending coronary artery. A total of 24 SD male rats were enrolled and divided randomly into the control group, I/R group, sufentanil group (SUF; 3 g/kg), and diltiazem group (DLZ; 20 mg/kg; positive control). The rat hearts were subjected to 30 min of ischemia followed by 120 min of reperfusion. Subsequently, hemodynamics, pathological changes of myocardial tissue, serum biochemical parameters, oxidative stress factors, the level of serum inducible nitric oxide synthases (iNOS), interleukin-6 (IL-6), and other bioactive factors were analyzed in the rats. Compared with the I/R group, sufentanil significantly improved cardiac action, myocardial fiber, and cardiomyocyte morphology and reduced inflammatory cell infiltration in rats in the SUF group. And the level of creatine kinase isoenzyme (CK-MB), troponin (cTn), lactate dehydrogenase (LDH), malondialdehyde (MDA), iNOS, and IL-6 was significantly declined in the serum of SUF group, while the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly activated in the myocardial tissues. In addition, sufentanil also significantly decreased the protein expression of GRP78, CHOP, Caspase 12, and ATF6 in the myocardial tissue of the SUF group. Sufentanil has a significant protective activity on myocardial I/R injury in rats, the mechanism of which may be associated with the inhibition of endoplasmic reticulum stress and oxidative stress. ObjectiveSufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective mechanism of sufentanil on rat myocardial ischemia-reperfusion (I/R) injury. MethodsA rat I/R model was established by ligating the left anterior descending coronary artery. A total of 24 SD male rats were enrolled and divided randomly into the control group, I/R group, sufentanil group (SUF; 3 μg/kg), and diltiazem group (DLZ; 20 mg/kg; positive control). The rat hearts were subjected to 30 min of ischemia followed by 120 min of reperfusion. Subsequently, hemodynamics, pathological changes of myocardial tissue, serum biochemical parameters, oxidative stress factors, the level of serum inducible nitric oxide synthases (iNOS), interleukin-6 (IL-6), and other bioactive factors were analyzed in the rats. ResultCompared with the I/R group, sufentanil significantly improved cardiac action, myocardial fiber, and cardiomyocyte morphology and reduced inflammatory cell infiltration in rats in the SUF group. And the level of creatine kinase isoenzyme (CK-MB), troponin (cTn), lactate dehydrogenase (LDH), malondialdehyde (MDA), iNOS, and IL-6 was significantly declined in the serum of SUF group, while the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly activated in the myocardial tissues. In addition, sufentanil also significantly decreased the protein expression of GRP78, CHOP, Caspase 12, and ATF6 in the myocardial tissue of the SUF group. ConclusionSufentanil has a significant protective activity on myocardial I/R injury in rats, the mechanism of which may be associated with the inhibition of endoplasmic reticulum stress and oxidative stress. |
| Author | Zhong, Guochen Lin, Jiayin Qiu, Liuji Sun, Laibao Hou, Zhiqi |
| AuthorAffiliation | 2 Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China 1 Department of Anesthesiology, Huizhou Central People's Hospital, Huizhou, Guangdong 516001, China |
| AuthorAffiliation_xml | – name: 1 Department of Anesthesiology, Huizhou Central People's Hospital, Huizhou, Guangdong 516001, China – name: 2 Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China |
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| Cites_doi | 10.1152/ajpheart.2001.280.5.H2313 10.1007/s12035-014-9033-x 10.21037/atm.2018.05.29 10.1007/s10753-020-01410-x 10.1152/ajpheart.00783.2002 10.1038/s41569-019-0218-x 10.1126/science.1209038 10.1371/journal.pone.0033491 10.1002/jcp.26848 10.1016/j.ejps.2011.02.005 10.1016/j.jacc.2015.02.032 10.1074/jbc.M701917200 10.1111/j.1399-6576.2011.02456.x 10.3390/molecules191016158 10.3892/ijmm.2019.4414 10.1146/annurev-pathol-012513-104649 10.1016/j.pharmthera.2011.11.004 10.1128/MCB.21.4.1249-1259.2001 10.1016/j.canlet.2008.07.005 10.1155/2019/6935147 10.1016/j.bbadis.2020.165768 10.1007/s10616-017-0127-y 10.1590/1414-431X20175861 10.1016/j.ijcard.2016.03.176 10.1159/000485089 10.1097/FJC.0b013e31824a7b60 10.3892/etm.2013.900 10.1002/jat.3249 10.1080/08923970701812530 10.1186/s12871-017-0331-5 10.1016/0891-5849(96)00177-3 10.1111/jcmm.16691 10.3389/fimmu.2018.03083 10.18632/aging.202276 10.1053/jcan.2002.128415 10.1016/j.jare.2020.09.001 10.1016/j.jss.2012.05.081 10.1186/1479-5876-9-73 10.1016/S0254-6272(13)60106-5 10.5114/ceji.2014.45939 10.1002/cphy.c160006 |
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| References | 37416180 - Comput Math Methods Med. 2023 Jun 28;2023:9815360 22 44 23 45 25 26 27 C. Wang (30) 2013; 29 28 M. B. Khosravi (24) 2019; 14 K. D. McCullough (9) 2001; 21 W. Quan (19) 2013; 33 31 L. He (39) 2017; 44 10 32 12 34 35 14 36 15 16 38 17 18 A. A. Nassiri (29) 2012; 6 L. D. Horwitz (37) 1996; 21 1 K. Gerlach (13) 2002; 16 2 3 E. Hochhauser (42) 2003; 284 4 Z. Chen (40) 2001; 280 J. Wu (33) 2018; 10 6 7 8 L. G. Hu (11) 2013; 5 E. Robin (5) 2007; 282 41 20 21 43 |
| References_xml | – volume: 280 start-page: H2313 issue: 5 year: 2001 ident: 40 article-title: Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice publication-title: American Journal of Physiology. Heart and Circulatory Physiology doi: 10.1152/ajpheart.2001.280.5.H2313 contributor: fullname: Z. Chen – ident: 34 doi: 10.1007/s12035-014-9033-x – ident: 2 doi: 10.21037/atm.2018.05.29 – ident: 18 doi: 10.1007/s10753-020-01410-x – volume: 10 start-page: 1109 issue: 4 year: 2018 ident: 33 article-title: Osthole attenuates myocardial ischemia/reperfusion injury in rats by inhibiting apoptosis and inflammation publication-title: American Journal of Translational Research contributor: fullname: J. Wu – volume: 284 start-page: H2351 issue: 6 year: 2003 ident: 42 article-title: Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice publication-title: American Journal of Physiology. Heart and Circulatory Physiology doi: 10.1152/ajpheart.00783.2002 contributor: fullname: E. Hochhauser – ident: 1 doi: 10.1038/s41569-019-0218-x – ident: 7 doi: 10.1126/science.1209038 – ident: 25 doi: 10.1371/journal.pone.0033491 – ident: 3 doi: 10.1002/jcp.26848 – ident: 41 doi: 10.1016/j.ejps.2011.02.005 – ident: 23 doi: 10.1016/j.jacc.2015.02.032 – volume: 282 start-page: 19133 issue: 26 year: 2007 ident: 5 article-title: Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion publication-title: The Journal of Biological Chemistry doi: 10.1074/jbc.M701917200 contributor: fullname: E. Robin – ident: 14 doi: 10.1111/j.1399-6576.2011.02456.x – ident: 28 doi: 10.3390/molecules191016158 – ident: 17 doi: 10.3892/ijmm.2019.4414 – ident: 8 doi: 10.1146/annurev-pathol-012513-104649 – ident: 38 doi: 10.1016/j.pharmthera.2011.11.004 – volume: 21 start-page: 1249 issue: 4 year: 2001 ident: 9 article-title: Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.21.4.1249-1259.2001 contributor: fullname: K. D. McCullough – ident: 10 doi: 10.1016/j.canlet.2008.07.005 – ident: 4 doi: 10.1155/2019/6935147 – ident: 35 doi: 10.1016/j.bbadis.2020.165768 – ident: 16 doi: 10.1007/s10616-017-0127-y – ident: 27 doi: 10.1590/1414-431X20175861 – volume: 6 start-page: 203 issue: 3 year: 2012 ident: 29 article-title: Differences in cardiovascular disease risk factors associated with maximum and mean carotid intima-media thickness among hemodialysis patients publication-title: Iranian Journal of Kidney Diseases contributor: fullname: A. A. Nassiri – ident: 6 doi: 10.1016/j.ijcard.2016.03.176 – volume: 44 start-page: 532 issue: 2 year: 2017 ident: 39 article-title: Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species publication-title: Cellular Physiology and Biochemistry doi: 10.1159/000485089 contributor: fullname: L. He – ident: 43 doi: 10.1097/FJC.0b013e31824a7b60 – volume: 5 start-page: 807 issue: 3 year: 2013 ident: 11 article-title: Effects of different doses of sufentanil and remifentanil combined with propofol in target-controlled infusion on stress reaction in elderly patients publication-title: Experimental and Therapeutic Medicine doi: 10.3892/etm.2013.900 contributor: fullname: L. G. Hu – volume: 29 start-page: 20 issue: 1 year: 2013 ident: 30 article-title: Panax quinquefolium saponins protect rat myocardium from ischemia/reperfusion injure through attenuating excessive endoplasmic reticulum stress publication-title: Chinese Journal of Pathophysiology contributor: fullname: C. Wang – ident: 31 doi: 10.1002/jat.3249 – ident: 45 doi: 10.1080/08923970701812530 – ident: 26 doi: 10.1186/s12871-017-0331-5 – volume: 14 start-page: 177 issue: 4 year: 2019 ident: 24 article-title: Effect of the aortic root infusion of sufentanil on ischemia-reperfusion injury in patients undergoing coronary artery bypass grafting: a randomized clinical trial publication-title: The Journal of Tehran Heart Center contributor: fullname: M. B. Khosravi – volume: 21 start-page: 743 issue: 6 year: 1996 ident: 37 article-title: Efficacy of lipid soluble, membrane-protective agents against hydrogen peroxide cytotoxicity in cardiac myocytes publication-title: Free Radical Biology & Medicine doi: 10.1016/0891-5849(96)00177-3 contributor: fullname: L. D. Horwitz – ident: 20 doi: 10.1111/jcmm.16691 – ident: 44 doi: 10.3389/fimmu.2018.03083 – ident: 22 doi: 10.18632/aging.202276 – volume: 16 start-page: 703 issue: 6 year: 2002 ident: 13 article-title: Remifentanil-clonidine-propofol versus sufentanil-propofol anesthesia for coronary artery bypass surgery publication-title: Journal of Cardiothoracic and Vascular Anesthesia doi: 10.1053/jcan.2002.128415 contributor: fullname: K. Gerlach – ident: 21 doi: 10.1016/j.jare.2020.09.001 – ident: 15 doi: 10.1016/j.jss.2012.05.081 – ident: 32 doi: 10.1186/1479-5876-9-73 – volume: 33 start-page: 85 issue: 1 year: 2013 ident: 19 article-title: Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro publication-title: Journal of Traditional Chinese Medicine doi: 10.1016/S0254-6272(13)60106-5 contributor: fullname: W. Quan – ident: 12 doi: 10.5114/ceji.2014.45939 – ident: 36 doi: 10.1002/cphy.c160006 |
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| Snippet | Objective. Sufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective... Sufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective mechanism of... ObjectiveSufentanil is the most common drug in clinical practice for the treatment of ischemic heart disease. This study is to investigate the protective... |
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| SubjectTerms | Animals Endoplasmic Reticulum Stress Humans Male Malondialdehyde Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Myocardium - pathology Rats Sufentanil - metabolism Sufentanil - pharmacology Sufentanil - therapeutic use |
| Title | Protective Effect of Sufentanil on Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting Endoplasmic Reticulum Stress |
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