Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane

Long-term peritoneal dialysis is associated with the development of functional and structural alterations of the peritoneal membrane. Long-term exposure to the high glucose concentrations in conventional peritoneal dialysate has been implicated in the pathogenesis of peritoneal hyperpermeability and...

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Bibliographic Details
Published in:	Journal of the American Society of Nephrology Vol. 12; no. 8; pp. 1734 - 1741
Main Authors:	DE VRIESE, An S, TILTON, Ronald G, STEPHAN, Clifford C, LAMEIRE, Norbert H
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-08-2001
Subjects:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Biological Transport Blood Vessels - pathology Capillary Permeability Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - pathology Emergency and intensive care: renal failure. Dialysis management Endothelial Growth Factors - antagonists & inhibitors Endothelial Growth Factors - immunology Endothelial Growth Factors - physiology Female Fluorescein-5-isothiocyanate - pharmacokinetics Hyperglycemia - physiopathology Intensive care medicine Lymphokines - antagonists & inhibitors Lymphokines - immunology Lymphokines - physiology Medical sciences Microcirculation Peritoneal Dialysis Peritoneum - blood supply Peritoneum - metabolism Rats Rats, Wistar Reference Values Serum Albumin - pharmacokinetics Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Kidney disease Urinary system disease Pathophysiology Rat Rodentia Peritoneal dialysis Extrarenal dialysis Vertebrata Chronic Hyperglycemia Mammalia Vascular endothelium growth factor Treatment Animal Renal failure Complication
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