Failure of preventing 5-fluorouracil cardiotoxicity by prophylactic treatment with verapamil

The most common cardiotoxic effects of 5-fluorouracil (5-FU) are chest pain and ischemic ECG abnormalities. Coronary vasospasm may be the underlying mechanism. If so, prophylactic treatment with calcium channel blockers might have a beneficial effect. In the present study, prophylaxis with verapamil...

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Bibliographic Details

Published in:	Acta oncologica Vol. 29; no. 8; p. 1001
Main Authors:	Eskilsson, J, Albertsson, M
Format:	Journal Article
Language:	English
Published:	England 1990
Subjects:	Adult Aged Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - prevention & control Chest Pain - chemically induced Chest Pain - prevention & control Female Fluorouracil - adverse effects Heart - drug effects Humans Male Middle Aged Verapamil - therapeutic use
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