A selective peroxisome proliferator-activated receptor δ agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice

Abstract Objective Although peroxisome proliferator-activated receptor (PPAR) δ agonists have been shown to improve the serum lipoprotein profiles in humans, the impact of the changes in these lipoprotein profiles on atherosclerosis remains to be elucidated. The aim of this study was to investigate...

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Bibliographic Details
Published in:	Metabolism, clinical and experimental Vol. 65; no. 1; pp. 16 - 25
Main Authors:	Naya, Noriyuki, Fukao, Keita, Nakamura, Akemi, Hamada, Tadateru, Sugimoto, Masayuki, Kojima, Midori, Yoshimura, Norito, Uwabe, Ken-Ichiro, Imagawa, Keiichi, Nomura, Kohji, Hara, Seijiro, Nakano, Toru, Iwasaki, Takanori, Shinosaki, Toshihiro, Hanasaki, Kohji
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 2016
Subjects:	Animals Apolipoprotein A-I (ApoA-I) Apolipoprotein A-I - blood Apolipoprotein B-100 - genetics Atherosclerosis Atherosclerosis - blood Atherosclerosis - prevention & control Chemokine CCL2 - blood Cholesterol Ester Transfer Proteins - genetics Endocrinology & Metabolism Female High-density lipoprotein (HDL) Humans Hypercholesterolemic dyslipidemia Lipoproteins, HDL - blood Mice Mice, Transgenic Peroxisome proliferator-activated receptor (PPAR) δ agonist Piperidines - pharmacology PPAR delta - agonists Pyrrolidines - pharmacology CETP FXR MCP-1 RXRα retinoic acid receptor alpha cholesteryl ester transfer protein high-density lipoprotein LXR Hypercholesterolemic dyslipidemia Peroxisome proliferator-activated receptor (PPAR) δ agonist apolipoprotein A-I hApoB100/hCETP-dTg macrophage chemoattractant protein-1 HDL PPAR LDL VLDL Atherosclerosis peroxisome proliferator-activated receptor retinoid X receptor High-density lipoprotein (HDL) farnesoid X receptor RARα low-density lipoprotein human apolipoprotein B100 and human cholesteryl ester transfer protein double transgenic ApoA-I TRβ very low-density lipoprotein Liver X receptor thyroid hormone receptor beta Apolipoprotein A-I (ApoA-I)
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