Matrix metalloproteinases in asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) are both highly prevalent, chronic inflammatory lung diseases that lead to significant morbidity and mortality. Matrix metalloproteinases (MMPs) are extracellular matrix degrading enzymes that play a critical role in normal development and phys...
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| Published in: | Current opinion in pharmacology Vol. 5; no. 3; pp. 257 - 263 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
01-06-2005
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| Abstract | Asthma and chronic obstructive pulmonary disease (COPD) are both highly prevalent, chronic inflammatory lung diseases that lead to significant morbidity and mortality. Matrix metalloproteinases (MMPs) are extracellular matrix degrading enzymes that play a critical role in normal development and physiological tissue remodeling and repair. In addition, they play an important role in the regulation of the kinetics and function of inflammatory cells. There is increasing evidence that MMPs are involved in the pathogenesis of both asthma and COPD, and several MMPs are possible therapeutic targets in these common chronic airway diseases. |
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| AbstractList | Asthma and chronic obstructive pulmonary disease (COPD) are both highly prevalent, chronic inflammatory lung diseases that lead to significant morbidity and mortality. Matrix metalloproteinases (MMPs) are extracellular matrix degrading enzymes that play a critical role in normal development and physiological tissue remodeling and repair. In addition, they play an important role in the regulation of the kinetics and function of inflammatory cells. There is increasing evidence that MMPs are involved in the pathogenesis of both asthma and COPD, and several MMPs are possible therapeutic targets in these common chronic airway diseases. |
| Author | Pauwels, Romain A Vermaelen, Karim Y Demedts, Ingel K Brusselle, Guy G Bracke, Ken R |
| Author_xml | – sequence: 1 givenname: Ingel K surname: Demedts fullname: Demedts, Ingel K email: M.DemedtsIngelK@UGent.be – sequence: 2 givenname: Guy G surname: Brusselle fullname: Brusselle, Guy G – sequence: 3 givenname: Ken R surname: Bracke fullname: Bracke, Ken R – sequence: 4 givenname: Karim Y surname: Vermaelen fullname: Vermaelen, Karim Y – sequence: 5 givenname: Romain A surname: Pauwels fullname: Pauwels, Romain A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15907912$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Asthma - drug therapy Asthma - enzymology Asthma - etiology Humans Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - adverse effects Matrix Metalloproteinases - physiology Protease Inhibitors - therapeutic use Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - etiology Tissue Inhibitor of Metalloproteinase-1 - therapeutic use |
| Title | Matrix metalloproteinases in asthma and COPD |
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