Metastatic cutaneous squamous cell carcinoma treated successfully with surgery, radiotherapy and S‐1/cisplatin chemotherapy

• Published in: Journal of dermatology Vol. 37; no. 7; pp. 666 - 670
• Main Authors: MATSUSHITA, Shigeto, KAWAI, Kazuhiro, TADA, Ko‐ichi, MERA, Kentaro, KUBO, Hidemichi, IBUSUKI, Atsuko, YOSHII, Noriko, KANEKURA, Takuro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-07-2010
• Subjects: Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - surgery; Carcinoma, Squamous Cell - therapy; Cisplatin - therapeutic use; Combined Modality Therapy - methods; concurrent chemoradiotherapy; cutaneous squamous cell carcinoma; Drug Combinations; histoculture drug response assay; Humans; lymph node metastasis; Lymphatic Metastasis; Male; Middle Aged; Oxonic Acid - therapeutic use; Skin Neoplasms - drug therapy; Skin Neoplasms - pathology; Skin Neoplasms - radiotherapy; Skin Neoplasms - surgery; Skin Neoplasms - therapy; S‐1/cisplatin; Tegafur - therapeutic use; Treatment Outcome
• ISSN: 0385-2407; 1346-8138
• DOI: 10.1111/j.1346-8138.2010.00829.x

Primary cutaneous squamous cell carcinoma (SCC) is a malignant tumor that arises from keratinizing cells of the epidermis or its appendages. We present a patient with cutaneous SCC on the left instep with metastases to multiple lymph nodes in the para‐aortic, iliac and groin region. We chose a combination of surgery and concurrent chemoradiotherapy. The chemotherapeutic agent S‐1/cisplatin was selected based on results of the histoculture drug response assay. The patient responded dramatically to this multidisciplinary treatment and complete remission was achieved.