Hemagglutinin-neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore
During 1999–2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin‐neuraminidase (HN) gene of eigh...
Saved in:
| Published in: | Journal of medical virology Vol. 70; no. 2; pp. 287 - 292 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New York
Wiley Subscription Services, Inc., A Wiley Company
01-06-2003
Wiley-Liss |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | During 1999–2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin‐neuraminidase (HN) gene of eight mumps virus isolates from patients with parotitis in Singapore were determined and compared with those of known vaccine strains. Phylogenetic trees constructed on the basis of HN nucleotide and amino acid sequences showed that the Singapore mumps virus isolates were more closely related to the Urabe strain and belonged to a different cluster from the Rubini and Jeryl‐Lynn strains. The Rubini vaccine showed only ∼93% nucleotide and ∼96% amino acid sequence similarity to Urabe and Singapore isolates. Compared with the vaccine strains, six of the eight isolates lacked the extracellular glycosylation site at residues 400–402. Other significant amino acid disparities (e.g., at residue 354) may also affect the antigenic properties of the HN protein. These findings suggest that the evolution and adaptation of the currently circulating mumps virus strains in the community has led to the emergence of genetically distinct viral strains. The low vaccine efficacy of the Rubini strain represents a major reason for the recent mumps resurgence and failure of mumps immunization in Singapore. J. Med. Virol. 70: 287–292, 2003. © 2003 Wiley‐Liss, Inc. |
|---|---|
| AbstractList | During 1999–2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin‐neuraminidase (HN) gene of eight mumps virus isolates from patients with parotitis in Singapore were determined and compared with those of known vaccine strains. Phylogenetic trees constructed on the basis of HN nucleotide and amino acid sequences showed that the Singapore mumps virus isolates were more closely related to the Urabe strain and belonged to a different cluster from the Rubini and Jeryl‐Lynn strains. The Rubini vaccine showed only ∼93% nucleotide and ∼96% amino acid sequence similarity to Urabe and Singapore isolates. Compared with the vaccine strains, six of the eight isolates lacked the extracellular glycosylation site at residues 400–402. Other significant amino acid disparities (e.g., at residue 354) may also affect the antigenic properties of the HN protein. These findings suggest that the evolution and adaptation of the currently circulating mumps virus strains in the community has led to the emergence of genetically distinct viral strains. The low vaccine efficacy of the Rubini strain represents a major reason for the recent mumps resurgence and failure of mumps immunization in Singapore. J. Med. Virol. 70: 287–292, 2003. © 2003 Wiley‐Liss, Inc. During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isolates from patients with parotitis in Singapore were determined and compared with those of known vaccine strains. Phylogenetic trees constructed on the basis of HN nucleotide and amino acid sequences showed that the Singapore mumps virus isolates were more closely related to the Urabe strain and belonged to a different cluster from the Rubini and Jeryl-Lynn strains. The Rubini vaccine showed only ~93% nucleotide and ~96% amino acid sequence similarity to Urabe and Singapore isolates. Compared with the vaccine strains, six of the eight isolates lacked the extracellular glycosylation site at residues 400-402. Other significant amino acid disparities (e.g. at residue 354) may also affect the antigenic properties of the HN protein. These findings suggest that the evolution and adaptation of the currently circulating mumps virus strains in the community has led to the emergence of genetically distinct viral strains. The low vaccine efficacy of the Rubini strain represents a major reason for the recent mumps resurgence and failure of mumps immunization in Singapore. During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isolates from patients with parotitis in Singapore were determined and compared with those of known vaccine strains. Phylogenetic trees constructed on the basis of HN nucleotide and amino acid sequences showed that the Singapore mumps virus isolates were more closely related to the Urabe strain and belonged to a different cluster from the Rubini and Jeryl-Lynn strains. The Rubini vaccine showed only approximately 93% nucleotide and approximately 96% amino acid sequence similarity to Urabe and Singapore isolates. Compared with the vaccine strains, six of the eight isolates lacked the extracellular glycosylation site at residues 400-402. Other significant amino acid disparities (e.g., at residue 354) may also affect the antigenic properties of the HN protein. These findings suggest that the evolution and adaptation of the currently circulating mumps virus strains in the community has led to the emergence of genetically distinct viral strains. The low vaccine efficacy of the Rubini strain represents a major reason for the recent mumps resurgence and failure of mumps immunization in Singapore. Abstract During 1999–2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin‐neuraminidase (HN) gene of eight mumps virus isolates from patients with parotitis in Singapore were determined and compared with those of known vaccine strains. Phylogenetic trees constructed on the basis of HN nucleotide and amino acid sequences showed that the Singapore mumps virus isolates were more closely related to the Urabe strain and belonged to a different cluster from the Rubini and Jeryl‐Lynn strains. The Rubini vaccine showed only ∼93% nucleotide and ∼96% amino acid sequence similarity to Urabe and Singapore isolates. Compared with the vaccine strains, six of the eight isolates lacked the extracellular glycosylation site at residues 400–402. Other significant amino acid disparities (e.g., at residue 354) may also affect the antigenic properties of the HN protein. These findings suggest that the evolution and adaptation of the currently circulating mumps virus strains in the community has led to the emergence of genetically distinct viral strains. The low vaccine efficacy of the Rubini strain represents a major reason for the recent mumps resurgence and failure of mumps immunization in Singapore. J. Med. Virol. 70: 287–292, 2003. © 2003 Wiley‐Liss, Inc. |
| Author | Lim, C.S. Goh, K.T. Chow, Vincent T.K. Chan, K.P. |
| Author_xml | – sequence: 1 givenname: C.S. surname: Lim fullname: Lim, C.S. organization: Department of Microbiology, Programme in Infectious Diseases, Faculty of Medicine, National University of Singapore, Kent Ridge, Singapore – sequence: 2 givenname: K.P. surname: Chan fullname: Chan, K.P. organization: Department of Pathology, Singapore General Hospital, Singapore – sequence: 3 givenname: K.T. surname: Goh fullname: Goh, K.T. organization: Quarantine and Epidemiology Department, National Environment Agency, Singapore – sequence: 4 givenname: Vincent T.K. surname: Chow fullname: Chow, Vincent T.K. email: micctk@nus.edu.sg organization: Department of Microbiology, Programme in Infectious Diseases, Faculty of Medicine, National University of Singapore, Kent Ridge, Singapore |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14747654$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12696120$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU1v1DAQhi3Uim4LB_4A8gUkDqH-ip0cUQUtVb9EoRwtx5ksLomd2snC3vjpuOyWnhCnGb3zvDMavftoxwcPCL2g5C0lhB3eDqvc8Jo_QQtKalnURNEdtCBUyEJKWu6h_ZRuCSFVzdhTtEeZrCVlZIF-ncBglst-npx3vvAwRzPktjUJcIK7GbwFbHyLx2_rPizBw-RsFky_TpBw6PAwD2PCKxfnhF0KvZmy3sUwYINXxlrns5L9YZzzzAWPncfXzi_NGCI8Q7ud6RM839YD9OXD-89HJ8XZ5fHHo3dnhRWM8EJJ1talEmVDSgmgZAeSNgpkw1oJhjeVEZ20UjRtQ2rb1lYpwa3kDSUVJ4IfoNebvWMM-as06cElC31vPIQ5acVpxUrC_wvSShFRKpbBNxvQxpBShE6P0Q0mrjUl-j4XnXPRf3LJ7Mvt0rkZoH0kt0Fk4NUWMMmavovGW5ceOaGEkuX9G4cb7ofrYf3vi_r0_ObhdLFxuDTBz78OE79rqbgq9deLY3316eaUX1xf6Yr_BqTnt_0 |
| CODEN | JMVIDB |
| CitedBy_id | crossref_primary_10_1097_01_inf_0000183746_92218_f9 crossref_primary_10_1093_glycob_cwy053 crossref_primary_10_1002_jmv_20047 crossref_primary_10_1002_jmv_20587 crossref_primary_10_47102_annals_acadmedsg_V36N12p969 crossref_primary_10_1080_00365540600606382 crossref_primary_10_3390_v14061335 crossref_primary_10_1186_1743_422X_7_195 crossref_primary_10_1002_rmv_1819 crossref_primary_10_1128_JVI_06019_11 crossref_primary_10_1111_j_1600_0463_2006_apm_463_x crossref_primary_10_1016_j_jinf_2004_10_001 crossref_primary_10_1016_j_meegid_2008_04_007 crossref_primary_10_1016_j_virol_2006_09_040 crossref_primary_10_1016_j_virol_2011_05_003 crossref_primary_10_1002_jmv_20065 crossref_primary_10_1002_jmv_21087 crossref_primary_10_1016_j_virusres_2004_11_013 crossref_primary_10_1099_vir_0_80200_0 crossref_primary_10_1002_jmv_20064 crossref_primary_10_1099_vir_0_062943_0 |
| Cites_doi | 10.1016/0168-1702(90)90073-K 10.1001/archpedi.1995.02170200064010 10.1016/0042-6822(87)90431-4 10.1128/CDLI.5.6.799-803.1998 10.1099/0022-1317-80-11-2923 10.4049/jimmunol.132.5.2622 10.1086/514170 10.1002/(SICI)1099-1654(199807/09)8:3<129::AID-RMV213>3.0.CO;2-Z 10.1016/S0140-6736(89)90332-2 10.1016/S0140-6736(99)02853-6 10.1086/517353 10.1099/0022-1317-71-4-987 10.3109/00365549609027163 10.1099/0022-1317-77-10-2491 10.1128/jvi.68.8.5093-5099.1994 10.1002/(SICI)1096-9071(199708)52:4<349::AID-JMV1>3.0.CO;2-1 10.1093/infdis/174.3.619 10.1016/S0264-410X(97)00174-6 10.1099/0022-1317-83-10-2489 10.1002/jmv.1890400211 10.1099/0022-1317-78-12-3187 10.1007/s705-002-8317-y 10.1007/s007050170088 10.1099/0022-1317-74-5-917 10.1099/0022-1317-82-11-2675 10.1093/infdis/169.1.77 |
| ContentType | Journal Article |
| Copyright | Copyright © 2003 Wiley‐Liss, Inc. 2003 INIST-CNRS Copyright 2003 Wiley-Liss, Inc. |
| Copyright_xml | – notice: Copyright © 2003 Wiley‐Liss, Inc. – notice: 2003 INIST-CNRS – notice: Copyright 2003 Wiley-Liss, Inc. |
| DBID | BSCLL IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U9 H94 7X8 |
| DOI | 10.1002/jmv.10393 |
| DatabaseName | Istex Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Virology and AIDS Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE - Academic MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1096-9071 |
| EndPage | 292 |
| ExternalDocumentID | 10_1002_jmv_10393 12696120 14747654 JMV10393 ark_67375_WNG_PRVJ3NSP_8 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Asia Singapore |
| GeographicLocations_xml | – name: Singapore |
| GrantInformation_xml | – fundername: Biomedical Research Council, Singapore |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 3O- 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AI. AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBD EBS ECGQY EJD ELTNK EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M65 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RGB RIWAO RJQFR ROL RWI RX1 RYL SAMSI SUPJJ SV3 TEORI TUS UB1 V2E VH1 W8V W99 WBKPD WHG WIB WIH WIJ WIK WJL WNSPC WOHZO WQJ WRC WUP WXI WXSBR WYISQ X7M XG1 XPP XV2 ZGI ZXP ZZTAW ~IA ~KM ~WT 08R AAUGY AAVGM ABHUG ACXME ADAWD ADDAD AFVGU AGJLS IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U9 H94 7X8 |
| ID | FETCH-LOGICAL-c4203-762d95745b056ee76fe61b7e6b2d6ea3b8a4f6c64bdb09cd9c7743c63b1083043 |
| IEDL.DBID | 33P |
| ISSN | 0146-6615 |
| IngestDate | Thu Aug 15 23:49:22 EDT 2024 Sat Aug 17 01:29:35 EDT 2024 Fri Aug 23 00:17:40 EDT 2024 Sat Sep 28 07:47:27 EDT 2024 Sun Oct 22 16:07:19 EDT 2023 Sat Aug 24 00:49:18 EDT 2024 Wed Oct 30 09:55:40 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Human Genetic variability Enzyme Hemagglutinin Glycoprotein Genotype Phylogeny Paramyxoviridae Infection Virus Paramyxovirinae Mononegavirales Glycosidases Viral disease Exo-α-sialidase Rubulavirus Hydrolases Mumps Mumps virus O-Glycosidases Clinical isolate |
| Language | English |
| License | CC BY 4.0 Copyright 2003 Wiley-Liss, Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4203-762d95745b056ee76fe61b7e6b2d6ea3b8a4f6c64bdb09cd9c7743c63b1083043 |
| Notes | Biomedical Research Council, Singapore ark:/67375/WNG-PRVJ3NSP-8 istex:2FFBDADFE85D5BE8B103E22562248DE10572152A ArticleID:JMV10393 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| PMID | 12696120 |
| PQID | 18704572 |
| PQPubID | 23462 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_73182503 proquest_miscellaneous_18704572 crossref_primary_10_1002_jmv_10393 pubmed_primary_12696120 pascalfrancis_primary_14747654 wiley_primary_10_1002_jmv_10393_JMV10393 istex_primary_ark_67375_WNG_PRVJ3NSP_8 |
| PublicationCentury | 2000 |
| PublicationDate | June 2003 |
| PublicationDateYYYYMMDD | 2003-06-01 |
| PublicationDate_xml | – month: 06 year: 2003 text: June 2003 |
| PublicationDecade | 2000 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: New York, NY – name: United States |
| PublicationTitle | Journal of medical virology |
| PublicationTitleAlternate | J. Med. Virol |
| PublicationYear | 2003 |
| Publisher | Wiley Subscription Services, Inc., A Wiley Company Wiley-Liss |
| Publisher_xml | – name: Wiley Subscription Services, Inc., A Wiley Company – name: Wiley-Liss |
| References | Jorgensen ED, Collins PL, Lomedico PT. 1987. Cloning and nucleotide sequence of Newcastle disease virus hemagglutinin-neuraminidase mRNA: identification of a putative sialic acid binding site. Virology 156: 12-24. Cusi MG, Correale P, Valassina M, Sabatino M, Valensin PE, Donati M, Gluck R. 2001. Comparative study of the immune response in mice immunized with four live attenuated strains of mumps virus by intranasal or intramuscular route. Arch Virol 146: 1241-1248. Chow VTK, Leong PWF. 1999. Complete nucleotide sequence, genomic organization and phylogenetic analysis of a novel genital human papillomavirus type, HLT7474-S. J Gen Virol 80: 2923-2929. Tecle T, Mickiene A, Johansson B, Lindquist L, Orvell C. 2002. Molecular characterisation of two mumps virus genotypes circulating during an epidemic in Lithuania from 1998 to 2000. Arch Virol 147: 243-253. Brown EG, Wright KE. 1998. Genetic studies on a mumps vaccine strain associated with meningitis. Rev Med Virol 8: 129-142. Wandel G. 1999. Mumps component in combined measles, mumps, and rubella vaccines. Vaccine 17: 511. Schwarzer S, Reibel S, Lang AB, Struck MM, Finkel B, Gerike E, Tischer A, Gassner M, Gluck R, Stuck B, Cryz SJ. 1998. Safety and characterization of the immune response engendered by two combined measles, mumps and rubella vaccines. Vaccine 16: 298-304. Cheek JE, Baron R, Atlas H, Wilson DL, Crider RD. 1995. Mumps outbreak in a highly vaccinated school population. Evidence for large-scale vaccination failure. Arch Pediatr Adolesc Med 149: 774-778. Briss PA, Fehrs LJ, Parker RA, Wright PF, Sannella EC, Hutcheson RH, Schaffner W. 1994. Sustained transmission of mumps in a highly vaccinated population: assessment of primary vaccine failure and waning vaccine-induced immunity. J Infect Dis 169: 77-82. Chungue E, Roche C, Lefevre MF, Barbazan P, Chanteau S. 1993. Ultra-rapid, simple, sensitive, and economical silica method for extraction of dengue viral RNA from clinical specimens and mosquitoes by reverse transcriptase-polymerase chain reaction. J Med Virol 40: 142-145. Germann D, Strohle A, Eggenberger K, Steiner CA, Matter L. 1996. An outbreak of mumps in a population partially vaccinated with the Rubini strain. Scand J Infect Dis 28: 235-238. Orvell C, Alsheikhly AR, Kalantari M, Johansson B. 1997. Characterization of genotype-specific epitopes of the HN protein of mumps virus. J Gen Virol 78: 3187-3193. Kovamees J, Rydbeck R, Orvell C, Norrby E. 1990. Hemagglutinin-neuraminidase (HN) amino acid alterations in neutralization escape mutants of Kilham mumps virus. Virus Res 17: 119-129. Chamot E, Toscani L, Egger P, Germann D, Bourquin C. 1998. Estimation of the efficacy of three strains of mumps vaccines during an epidemic of mumps in the Geneva canton (Switzerland). Rev Epidemiol Sante Pub 46: 100-107. Gray JA, Burns SM. 1989. Mumps meningitis following measles, mumps, and rubella immunization. Lancet 2: 98. Afzal MA, Yates PJ, Minor PD. 1998. Nucleotide sequence at position 1081 of the hemagglutinin-neuraminidase gene in the mumps Urabe vaccine strain. J Infect Dis 177: 265-266. Brown EG, Dimock K, Wright KE. 1996. The Urabe AM9 mumps vaccine is a mixture of viruses differing at amino acid 335 of the hemagglutinin-neuraminidase gene with one form associated with disease. J Infect Dis 174: 619-622. Afzal MA, Pickford AR, Forsey T, Heath AB, Minor PD. 1993. The Jeryl Lynn vaccine strain of mumps virus is a mixture of two distinct isolates. J Gen Virol 74: 917-920. Crennell S, Takimoto T, Portner A, Taylor G. 2000. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nat Struct Biol 11: 1068-1074. Forsey T, Mawn JA, Yates PJ, Bentley ML, Minor PD. 1990. Differentiation of vaccine and wild mumps viruses using the polymerase chain reaction and dideoxynucleotide sequencing. J Gen Virol 71: 987-990. Narita M, Matsuzono Y, Takekoshi Y, Yamada S, Itakura O, Kubota M, Kikuta H, Togashi T. 1998. Analysis of mumps vaccine failure by means of avidity testing for mumps virus-specific immunoglobulin G. Clin Diagn Lab Immunol 5: 799-803. Yates PJ, Afzal MA, Minor PD. 1996. Antigenic and genetic variation of the HN protein of mumps virus strains. J Gen Virol 77: 2491-2497. Tecle T, Bottiger B, Orvell C, Johansson B. 2001. Characterization of two decades of temporal co-circulation of four mumps virus genotypes in Denmark: identification of a new genotype. J Gen Virol 82: 2675-2680. Afzal MA, Buchanan J, Dias JA, Cordeiro M, Bentley ML, Shorrock CA, Minor PD. 1997. RT-PCR based diagnosis and molecular characterisation of mumps viruses derived from clinical specimens collected during the 1996 mumps outbreak in Portugal. J Med Virol 52: 349-353. Orvell C. 1984. The reactions of monoclonal antibodies with structural proteins of mumps virus. J Immunol 132: 2622-2629. Schulze IT. 1997. Effects of glycosylation on the properties and functions of influenza virus hemagglutinin. J Infect Dis 176(suppl 1): S24-S28. Committee on Epidemic Diseases. 2000. Efficacy of mumps virus vaccine. Epidemiol News Bull 26: 45-47. Mirza AM, Deng R, Iorio RM. 1994. Site-directed mutagenesis of a conserved hexapeptide in the paramyxovirus hemagglutinin-neuraminidase glycoprotein: effects on antigenic structure and function. J Virol 68: 5093-5099. Goh KT. 1999. Resurgence of mumps in Singapore caused by the Rubini mumps virus vaccine strain. Lancet 354: 1355-1356. Orvell C, Tecle T, Johansson B, Saito H, Samuelson A. 2002. Antigenic relationships between six genotypes of the small hydrophobic protein gene of mumps virus. J Gen Virol 83: 2489-2496. 1989; 2 2001; 146 1993; 40 2000; 26 1990; 17 1997; 176 1994; 68 1998; 177 1999; 80 1998; 46 1996; 77 1998; 16 2001; 82 1987; 156 1984; 132 1996; 28 1994; 169 2002; 83 1997; 52 1999; 17 2000; 11 2002; 147 1993; 74 1997; 78 1995; 149 1996; 174 1999; 354 1998; 5 1990; 71 1998; 8 Mirza AM (e_1_2_1_21_1) 1994; 68 Chow VTK (e_1_2_1_10_1) 1999; 80 e_1_2_1_20_1 Crennell S (e_1_2_1_13_1) 2000; 11 e_1_2_1_24_1 e_1_2_1_22_1 e_1_2_1_27_1 Wandel G (e_1_2_1_30_1) 1999; 17 e_1_2_1_28_1 e_1_2_1_25_1 e_1_2_1_26_1 e_1_2_1_29_1 Orvell C (e_1_2_1_23_1) 1984; 132 Committee on Epidemic Diseases (e_1_2_1_12_1) 2000; 26 Chamot E (e_1_2_1_8_1) 1998; 46 e_1_2_1_7_1 e_1_2_1_31_1 e_1_2_1_5_1 e_1_2_1_6_1 e_1_2_1_3_1 e_1_2_1_4_1 e_1_2_1_2_1 e_1_2_1_11_1 e_1_2_1_16_1 e_1_2_1_17_1 e_1_2_1_14_1 e_1_2_1_15_1 e_1_2_1_9_1 e_1_2_1_18_1 e_1_2_1_19_1 |
| References_xml | – volume: 174 start-page: 619 year: 1996 end-page: 622 article-title: The Urabe AM9 mumps vaccine is a mixture of viruses differing at amino acid 335 of the hemagglutinin‐neuraminidase gene with one form associated with disease publication-title: J Infect Dis – volume: 177 start-page: 265 year: 1998 end-page: 266 article-title: Nucleotide sequence at position 1081 of the hemagglutinin‐neuraminidase gene in the mumps Urabe vaccine strain publication-title: J Infect Dis – volume: 354 start-page: 1355 year: 1999 end-page: 1356 article-title: Resurgence of mumps in Singapore caused by the Rubini mumps virus vaccine strain publication-title: Lancet – volume: 82 start-page: 2675 year: 2001 end-page: 2680 article-title: Characterization of two decades of temporal co‐circulation of four mumps virus genotypes in Denmark: identification of a new genotype publication-title: J Gen Virol – volume: 74 start-page: 917 year: 1993 end-page: 920 article-title: The Jeryl Lynn vaccine strain of mumps virus is a mixture of two distinct isolates publication-title: J Gen Virol – volume: 80 start-page: 2923 year: 1999 end-page: 2929 article-title: Complete nucleotide sequence, genomic organization and phylogenetic analysis of a novel genital human papillomavirus type, HLT7474‐S publication-title: J Gen Virol – volume: 28 start-page: 235 year: 1996 end-page: 238 article-title: An outbreak of mumps in a population partially vaccinated with the Rubini strain publication-title: Scand J Infect Dis – volume: 2 start-page: 98 year: 1989 article-title: Mumps meningitis following measles, mumps, and rubella immunization publication-title: Lancet – volume: 132 start-page: 2622 year: 1984 end-page: 2629 article-title: The reactions of monoclonal antibodies with structural proteins of mumps virus publication-title: J Immunol – volume: 83 start-page: 2489 year: 2002 end-page: 2496 article-title: Antigenic relationships between six genotypes of the small hydrophobic protein gene of mumps virus publication-title: J Gen Virol – volume: 176 start-page: S24 issue: suppl 1 year: 1997 end-page: S28 article-title: Effects of glycosylation on the properties and functions of influenza virus hemagglutinin publication-title: J Infect Dis – volume: 26 start-page: 45 year: 2000 end-page: 47 article-title: Efficacy of mumps virus vaccine publication-title: Epidemiol News Bull – volume: 147 start-page: 243 year: 2002 end-page: 253 article-title: Molecular characterisation of two mumps virus genotypes circulating during an epidemic in Lithuania from 1998 to 2000 publication-title: Arch Virol – volume: 52 start-page: 349 year: 1997 end-page: 353 article-title: RT‐PCR based diagnosis and molecular characterisation of mumps viruses derived from clinical specimens collected during the 1996 mumps outbreak in Portugal publication-title: J Med Virol – volume: 71 start-page: 987 year: 1990 end-page: 990 article-title: Differentiation of vaccine and wild mumps viruses using the polymerase chain reaction and dideoxynucleotide sequencing publication-title: J Gen Virol – volume: 40 start-page: 142 year: 1993 end-page: 145 article-title: Ultra‐rapid, simple, sensitive, and economical silica method for extraction of dengue viral RNA from clinical specimens and mosquitoes by reverse transcriptase‐polymerase chain reaction publication-title: J Med Virol – volume: 11 start-page: 1068 year: 2000 end-page: 1074 article-title: Crystal structure of the multifunctional paramyxovirus hemagglutinin‐neuraminidase publication-title: Nat Struct Biol – volume: 5 start-page: 799 year: 1998 end-page: 803 article-title: Analysis of mumps vaccine failure by means of avidity testing for mumps virus‐specific immunoglobulin G publication-title: Clin Diagn Lab Immunol – volume: 156 start-page: 12 year: 1987 end-page: 24 article-title: Cloning and nucleotide sequence of Newcastle disease virus hemagglutinin‐neuraminidase mRNA: identification of a putative sialic acid binding site publication-title: Virology – volume: 17 start-page: 511 year: 1999 article-title: Mumps component in combined measles, mumps, and rubella vaccines publication-title: Vaccine – volume: 146 start-page: 1241 year: 2001 end-page: 1248 article-title: Comparative study of the immune response in mice immunized with four live attenuated strains of mumps virus by intranasal or intramuscular route publication-title: Arch Virol – volume: 149 start-page: 774 year: 1995 end-page: 778 article-title: Mumps outbreak in a highly vaccinated school population. Evidence for large‐scale vaccination failure publication-title: Arch Pediatr Adolesc Med – volume: 77 start-page: 2491 year: 1996 end-page: 2497 article-title: Antigenic and genetic variation of the HN protein of mumps virus strains publication-title: J Gen Virol – volume: 16 start-page: 298 year: 1998 end-page: 304 article-title: Safety and characterization of the immune response engendered by two combined measles, mumps and rubella vaccines publication-title: Vaccine – volume: 169 start-page: 77 year: 1994 end-page: 82 article-title: Sustained transmission of mumps in a highly vaccinated population: assessment of primary vaccine failure and waning vaccine‐induced immunity publication-title: J Infect Dis – volume: 17 start-page: 119 year: 1990 end-page: 129 article-title: Hemagglutinin‐neuraminidase (HN) amino acid alterations in neutralization escape mutants of Kilham mumps virus publication-title: Virus Res – volume: 8 start-page: 129 year: 1998 end-page: 142 article-title: Genetic studies on a mumps vaccine strain associated with meningitis publication-title: Rev Med Virol – volume: 46 start-page: 100 year: 1998 end-page: 107 article-title: Estimation of the efficacy of three strains of mumps vaccines during an epidemic of mumps in the Geneva canton (Switzerland) publication-title: Rev Epidemiol Sante Pub – volume: 68 start-page: 5093 year: 1994 end-page: 5099 article-title: Site‐directed mutagenesis of a conserved hexapeptide in the paramyxovirus hemagglutinin‐neuraminidase glycoprotein: effects on antigenic structure and function publication-title: J Virol – volume: 78 start-page: 3187 year: 1997 end-page: 3193 article-title: Characterization of genotype‐specific epitopes of the HN protein of mumps virus publication-title: J Gen Virol – ident: e_1_2_1_20_1 doi: 10.1016/0168-1702(90)90073-K – ident: e_1_2_1_9_1 doi: 10.1001/archpedi.1995.02170200064010 – ident: e_1_2_1_19_1 doi: 10.1016/0042-6822(87)90431-4 – volume: 11 start-page: 1068 year: 2000 ident: e_1_2_1_13_1 article-title: Crystal structure of the multifunctional paramyxovirus hemagglutinin‐neuraminidase publication-title: Nat Struct Biol contributor: fullname: Crennell S – ident: e_1_2_1_22_1 doi: 10.1128/CDLI.5.6.799-803.1998 – volume: 80 start-page: 2923 year: 1999 ident: e_1_2_1_10_1 article-title: Complete nucleotide sequence, genomic organization and phylogenetic analysis of a novel genital human papillomavirus type, HLT7474‐S publication-title: J Gen Virol doi: 10.1099/0022-1317-80-11-2923 contributor: fullname: Chow VTK – volume: 132 start-page: 2622 year: 1984 ident: e_1_2_1_23_1 article-title: The reactions of monoclonal antibodies with structural proteins of mumps virus publication-title: J Immunol doi: 10.4049/jimmunol.132.5.2622 contributor: fullname: Orvell C – volume: 46 start-page: 100 year: 1998 ident: e_1_2_1_8_1 article-title: Estimation of the efficacy of three strains of mumps vaccines during an epidemic of mumps in the Geneva canton (Switzerland) publication-title: Rev Epidemiol Sante Pub contributor: fullname: Chamot E – ident: e_1_2_1_26_1 doi: 10.1086/514170 – ident: e_1_2_1_6_1 doi: 10.1002/(SICI)1099-1654(199807/09)8:3<129::AID-RMV213>3.0.CO;2-Z – ident: e_1_2_1_18_1 doi: 10.1016/S0140-6736(89)90332-2 – ident: e_1_2_1_17_1 doi: 10.1016/S0140-6736(99)02853-6 – ident: e_1_2_1_4_1 doi: 10.1086/517353 – ident: e_1_2_1_15_1 doi: 10.1099/0022-1317-71-4-987 – ident: e_1_2_1_16_1 doi: 10.3109/00365549609027163 – ident: e_1_2_1_31_1 doi: 10.1099/0022-1317-77-10-2491 – volume: 68 start-page: 5093 year: 1994 ident: e_1_2_1_21_1 article-title: Site‐directed mutagenesis of a conserved hexapeptide in the paramyxovirus hemagglutinin‐neuraminidase glycoprotein: effects on antigenic structure and function publication-title: J Virol doi: 10.1128/jvi.68.8.5093-5099.1994 contributor: fullname: Mirza AM – volume: 17 start-page: 511 year: 1999 ident: e_1_2_1_30_1 article-title: Mumps component in combined measles, mumps, and rubella vaccines publication-title: Vaccine contributor: fullname: Wandel G – ident: e_1_2_1_3_1 doi: 10.1002/(SICI)1096-9071(199708)52:4<349::AID-JMV1>3.0.CO;2-1 – ident: e_1_2_1_7_1 doi: 10.1093/infdis/174.3.619 – ident: e_1_2_1_27_1 doi: 10.1016/S0264-410X(97)00174-6 – volume: 26 start-page: 45 year: 2000 ident: e_1_2_1_12_1 article-title: Efficacy of mumps virus vaccine publication-title: Epidemiol News Bull contributor: fullname: Committee on Epidemic Diseases – ident: e_1_2_1_25_1 doi: 10.1099/0022-1317-83-10-2489 – ident: e_1_2_1_11_1 doi: 10.1002/jmv.1890400211 – ident: e_1_2_1_24_1 doi: 10.1099/0022-1317-78-12-3187 – ident: e_1_2_1_29_1 doi: 10.1007/s705-002-8317-y – ident: e_1_2_1_14_1 doi: 10.1007/s007050170088 – ident: e_1_2_1_2_1 doi: 10.1099/0022-1317-74-5-917 – ident: e_1_2_1_28_1 doi: 10.1099/0022-1317-82-11-2675 – ident: e_1_2_1_5_1 doi: 10.1093/infdis/169.1.77 |
| SSID | ssj0008922 |
| Score | 1.8811343 |
| Snippet | During 1999–2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini... During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini... Abstract During 1999–2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the... |
| SourceID | proquest crossref pubmed pascalfrancis wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 287 |
| SubjectTerms | Amino Acid Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics HN gene HN Protein - chemistry HN Protein - genetics Human viral diseases Humans Infectious diseases Medical sciences Microbiology Molecular Sequence Data Mumps - virology Mumps Vaccine - administration & dosage mumps virus Mumps virus - classification Mumps virus - genetics Mumps virus - isolation & purification Parotitis - virology Phylogeny Polymerase Chain Reaction Rubini vaccine failure Sequence Analysis, DNA Singapore Treatment Failure Tropical medicine Vaccination Viral diseases Viral diseases of the respiratory system and ent viral diseases Virology |
| Title | Hemagglutinin-neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore |
| URI | https://api.istex.fr/ark:/67375/WNG-PRVJ3NSP-8/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmv.10393 https://www.ncbi.nlm.nih.gov/pubmed/12696120 https://search.proquest.com/docview/18704572 https://search.proquest.com/docview/73182503 |
| Volume | 70 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1fi9QwEA96gvjif8_65wwi4ku4Nk2TBp9E7zwObllcPX0LSZMeq2z32N4uPoqfwM_oJ3Em3XZZ8EDwrYQkbTKTyW-azG8IeYFqoaUPTAeXMiGsYs5Lzrws68IJUWcqJrGdqNGX8t0B0uS87mNhOn6I4Ycbroxor3GBW9fub0hDv85WGDGukekTvIQYvpGPBytc6u4EASwBgz2o6FmFUr4_tNzai67htH7Hu5G2hempu7wWfwOe2zg2bkSHt_5rCLfJzTX-pG86hblDroTmLrl-sj5hv0d-HoWZPTtDfWymze8fv5Dw0iIBiYf9jvY3r6ltPAUJgeUEYwl9QQGym4SWzms6Ax1p6Wq6WLZ0CsqNeJZiIAu1dGUreBOUQPsheRidNnSCybnBGwj3yafDg49vj9g6TwOrBE9zBvbU60KJwgGaCkHJOsjMqSAd9zLY3JVW1LKSwnmX6srrCjBnXsncZQAAU5E_IDvNvAkPCfUiD-A146GDFSL1WoRaY0gj6A93WZaQ573EzHlHx2E64mVuYDZNnM2EvIyyHGrYxTe8v6YK83n03ow_nB7no8nYlAnZ2xL2pksBXpYsREKe9dI3sOzwLMU2Yb5sTQZ2ThSKX15DgbUEfAlfs9upzaZ3LjUAyzQhr6J2XD4Sc3xyGh8e_XvVx-QG71JEsjR7QnYuFsvwlFxt_XIvrpA_u2YU-w |
| link.rule.ids | 315,782,786,1408,27935,27936,46066,46490 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFD5imwS8cL-Ey2YhhHiJlsSOE0u8INgoY60qOgZvlh07Uzc1RQ2teET8An4jv4RzkqZVJSYh8RZFthP7XPz5cr4D8JzUQknnQ-VtFAphstA6mYRO5mVqhSjjrEliO8oGX_K3B0ST86qLhWn5IVYbbmQZjb8mA6cN6f01a-j5ZEEh44pvwY6QQlHiBs6HKz-cq_YMAX1BiLNQ2vEKRcn-qurGbLRDA_udbkeaGgeobDNb_A16biLZZio6vPl_nbgFN5YQlL1udeY2XPHVHbjaXx6y34WfPT8xZ2ekktW4-v3jF3FeGuIgcTjlse7yNTOVYygkdJ7oL7EtfEEEJ75m05JNUE1qthjP5jUbo34TpGUUy8IMW5gCv4RvsP4qfxgbV2xE-blxQeDvwafDg5M3vXCZqiEsRBLxEF2qU2kmUouAyvtMll7GNvPSJk56w21uRCkLKayzkSqcKhB28kJyGyMGjAS_D9vVtPIPgTnBPS6c6dzBCBE5JXypKKoRVSixcRzAs05k-mvLyKFb7uVE42jqZjQDeNEIc1XCzC7oCluW6s-Dd3r48fSID0ZDnQewuyHtdZMCF1oyFQHsdeLXaHl0nGIqP53XOkZXJ9IsubxEhg4TISb-zYNWb9atJ1IhtowCeNmox-U90Uf90-bh0b8X3YNrvZP-sT5-P_jwGK4nbcbIMIqfwPa32dw_ha3azXcbc_kDBmwZHA |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RVqq48H6ER2shhLhETRzHicUJ0S6l0NWKhcLNsmOnWtBmqw274oj4BfxGfgkzySarlaiExC2ybCeeGY8_x55vAJ6SWSjpfKi8jUIhTBZaJ3noZF6mVogyzpoktuNs-Dk_PCKanBddLEzLD9H_cKOZ0fhrmuAXrjxYk4Z-mS4pYlwlW7AjCIZT_EYy6t1wrtojBHQFIS5CaUcrFPGDvunGYrRDcv1OlyNNjfIp28QWf0Oem0C2WYkG1_9rDDfg2gqAspetxdyEK766BbunqyP22_Dz2E_N-TkZZDWpfv_4RYyXhhhIHC54rLt6zUzlGKoIXSd6S-wLC4jexNdsVrIpGknNlpP5omYTtG4CtIwiWZhhS1Pgm7AE2_fZw9ikYmPKzo3bAX8HPg6OPrw6DleJGsJC8CgJ0aE6lWYitQinvM9k6WVsMy8td9KbxOZGlLKQwjobqcKpAkFnUsjExogAI5Hche1qVvn7wJxIPG6b6dTBCBE5JXypKKYRDYjbOA7gSacxfdHyceiWeZlrlKZupBnAs0aXfQ0z_0oX2LJUfxq-1qP3ZyfJcDzSeQB7G8pedylwmyVTEcB-p32N844OU0zlZ4tax-joRJrxy2tk6C4RYOLX3GvNZt07lwqRZRTA88Y6Lh-JPjk9ax4e_HvVfdgdHQ70uzfDtw_hKm_TRYZR_Ai2v80X_jFs1W6x10yWP67tF8s |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hemagglutinin%E2%80%90neuraminidase+sequence+and+phylogenetic+analyses+of+mumps+virus+isolates+from+a+vaccinated+population+in+Singapore&rft.jtitle=Journal+of+medical+virology&rft.au=Lim%2C+C.S.&rft.au=Chan%2C+K.P.&rft.au=Goh%2C+K.T.&rft.au=Chow%2C+Vincent+T.K.&rft.date=2003-06-01&rft.pub=Wiley+Subscription+Services%2C+Inc.%2C+A+Wiley+Company&rft.issn=0146-6615&rft.eissn=1096-9071&rft.volume=70&rft.issue=2&rft.spage=287&rft.epage=292&rft_id=info:doi/10.1002%2Fjmv.10393&rft.externalDBID=10.1002%252Fjmv.10393&rft.externalDocID=JMV10393 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0146-6615&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0146-6615&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0146-6615&client=summon |