Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2
CA IX is a tumour‐associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal, benign and malignant breast tissues and compared with expression of breast tumour markers including oestrogen receptor, c‐erbB2, c‐erbB3 and...
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| Published in: | The Journal of pathology Vol. 197; no. 3; pp. 314 - 321 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
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Chichester, UK
John Wiley & Sons, Ltd
01-07-2002
Wiley |
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| Abstract | CA IX is a tumour‐associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal, benign and malignant breast tissues and compared with expression of breast tumour markers including oestrogen receptor, c‐erbB2, c‐erbB3 and CD44. Tissue specimens were analysed using immunohistochemistry and/or reverse transcriptase–polymerase chain reaction (RT‐PCR). CA IX was detected by IHC in 12/26 (46%) malignant tissues, 4/36 (11%) benign lesions, but not in 10 normal breasts. Staining was mostly confined to plasma membranes of abnormal epithelial cells, but in five cases was found in adjacent stroma. Semi‐quantitative RT‐PCR detected CA9 mRNA in 25/39 (64%) malignant tumours, 11/33 (33%) benign lesions, but in none of three normal breasts. Comparative RT‐PCR analysis of malignant tissues revealed a relationship between CA9 positivity and c‐erbB2 overexpression (p=0.05). Moreover, CA9‐positive specimens displayed a significantly higher median level of c‐erbB2 than CA9‐negative ones (p=0.02). No significant association was found with the other markers. The results of this study support the possible importance of CA IX for breast carcinogenesis and suggest its potential use as a breast tumour marker. Copyright © 2002 John Wiley & Sons, Ltd. |
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| AbstractList | CA IX is a tumour‐associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal, benign and malignant breast tissues and compared with expression of breast tumour markers including oestrogen receptor, c‐erbB2, c‐erbB3 and CD44. Tissue specimens were analysed using immunohistochemistry and/or reverse transcriptase–polymerase chain reaction (RT‐PCR). CA IX was detected by IHC in 12/26 (46%) malignant tissues, 4/36 (11%) benign lesions, but not in 10 normal breasts. Staining was mostly confined to plasma membranes of abnormal epithelial cells, but in five cases was found in adjacent stroma. Semi‐quantitative RT‐PCR detected CA9 mRNA in 25/39 (64%) malignant tumours, 11/33 (33%) benign lesions, but in none of three normal breasts. Comparative RT‐PCR analysis of malignant tissues revealed a relationship between CA9 positivity and c‐erbB2 overexpression (p=0.05). Moreover, CA9‐positive specimens displayed a significantly higher median level of c‐erbB2 than CA9‐negative ones (p=0.02). No significant association was found with the other markers. The results of this study support the possible importance of CA IX for breast carcinogenesis and suggest its potential use as a breast tumour marker. Copyright © 2002 John Wiley & Sons, Ltd. CA IX is a tumour-associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal, benign and malignant breast tissues and compared with expression of breast tumour markers including oestrogen receptor, c-erbB2, c-erbB3 and CD44. Tissue specimens were analysed using immunohistochemistry and/or reverse transcriptase-polymerase chain reaction (RT-PCR). CA IX was detected by IHC in 12/26 (46%) malignant tissues, 4/36 (11%) benign lesions, but not in 10 normal breasts. Staining was mostly confined to plasma membranes of abnormal epithelial cells, but in five cases was found in adjacent stroma. Semi-quantitative RT-PCR detected CA9 mRNA in 25/39 (64%) malignant tumours, 11/33 (33%) benign lesions, but in none of three normal breasts. Comparative RT-PCR analysis of malignant tissues revealed a relationship between CA9 positivity and c-erbB2 overexpression (p=0.05). Moreover, CA9-positive specimens displayed a significantly higher median level of c-erbB2 than CA9-negative ones (p=0.02). No significant association was found with the other markers. The results of this study support the possible importance of CA IX for breast carcinogenesis and suggest its potential use as a breast tumour marker. CA IX is a tumour‐associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal, benign and malignant breast tissues and compared with expression of breast tumour markers including oestrogen receptor, c‐erbB2, c‐erbB3 and CD44. Tissue specimens were analysed using immunohistochemistry and/or reverse transcriptase–polymerase chain reaction (RT‐PCR). CA IX was detected by IHC in 12/26 (46%) malignant tissues, 4/36 (11%) benign lesions, but not in 10 normal breasts. Staining was mostly confined to plasma membranes of abnormal epithelial cells, but in five cases was found in adjacent stroma. Semi‐quantitative RT‐PCR detected CA9 mRNA in 25/39 (64%) malignant tumours, 11/33 (33%) benign lesions, but in none of three normal breasts. Comparative RT‐PCR analysis of malignant tissues revealed a relationship between CA9 positivity and c‐erb B2 overexpression ( p =0.05). Moreover, CA9 ‐positive specimens displayed a significantly higher median level of c‐erb B2 than CA9 ‐negative ones ( p =0.02). No significant association was found with the other markers. The results of this study support the possible importance of CA IX for breast carcinogenesis and suggest its potential use as a breast tumour marker. Copyright © 2002 John Wiley & Sons, Ltd. |
| Author | Mucha, Vojtech Pohlodek, Kamil Karttunen, Tuomo J. Parkkila, Seppo Pastorek, Jaromír Galbavý, Štefan Harris, Adrian L. Bartošová, Mária Pastoreková, Silvia |
| Author_xml | – sequence: 1 givenname: Mária surname: Bartošová fullname: Bartošová, Mária organization: Department of Molecular Biology, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic – sequence: 2 givenname: Seppo surname: Parkkila fullname: Parkkila, Seppo organization: Department of Anatomy and Cell Biology, Oulu University, Oulu, Finland – sequence: 3 givenname: Kamil surname: Pohlodek fullname: Pohlodek, Kamil organization: Department of Gynaecology and Obstetrics II, School of Medicine, Comenius University, Bratislava, Slovak Republic – sequence: 4 givenname: Tuomo J. surname: Karttunen fullname: Karttunen, Tuomo J. organization: Department of Pathology, Oulu University, Oulu, Finland – sequence: 5 givenname: Štefan surname: Galbavý fullname: Galbavý, Štefan organization: Department of Pathology, School of Medicine, Comenius University, Bratislava, Slovak Republic – sequence: 6 givenname: Vojtech surname: Mucha fullname: Mucha, Vojtech organization: Department of Molecular Biology, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic – sequence: 7 givenname: Adrian L. surname: Harris fullname: Harris, Adrian L. organization: Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK – sequence: 8 givenname: Jaromír surname: Pastorek fullname: Pastorek, Jaromír organization: Department of Molecular Biology, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic – sequence: 9 givenname: Silvia surname: Pastoreková fullname: Pastoreková, Silvia email: virupast@savba.sk organization: Department of Molecular Biology, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic |
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| Copyright | Copyright © 2002 John Wiley & Sons, Ltd. 2002 INIST-CNRS Copyright 2002 John Wiley & Sons, Ltd. |
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| Issue | 3 |
| Keywords | Human Immunohistochemistry Carcinoma Enzyme Gene overexpression Lyases Tumoral marker Malignant tumor Gene expression Carcinogenesis Polymerase chain reaction Pathology Mammary gland diseases C-Onc gene Carbonate dehydratase Mammary gland Benign neoplasm Molecular biology Carbon-oxygen lyases Protooncogene Hydro-lyases |
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| Snippet | CA IX is a tumour‐associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal,... CA IX is a tumour-associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication. Its distribution was examined in normal,... |
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| SubjectTerms | Adult Aged Aged, 80 and over Antigens, Neoplasm Biological and medical sciences Biomarkers, Tumor - analysis Breast - chemistry breast carcinogenesis Breast Neoplasms - chemistry Breast Neoplasms - genetics c-erbB2 Carbonic Anhydrase IX Carbonic Anhydrases - analysis Chi-Square Distribution Female Genes, erbB-2 Gynecology. Andrology. Obstetrics Humans Hyaluronan Receptors - analysis Immunohistochemistry Mammary gland diseases Medical sciences Middle Aged Neoplasm Proteins - analysis Receptors, Estrogen - analysis Reverse Transcriptase Polymerase Chain Reaction semi-quantitative RT-PCR Tumors |
| Title | Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2 |
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