Stromelysin (MMP‐3) Synthesis Is Up‐Regulated in Estrogen‐Deficient Mouse Osteoblasts In Vivo and In Vitro

Sex steroids are important regulators of bone cell function and osteoblast‐derived matrix metalloproteinases (MMPs) are key mediators of bone resorption during the initial stage of osteoid removal prior to osteoclast attachment. To investigate the mechanism of bone loss following estrogen deficiency...

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Bibliographic Details
Published in:	Journal of bone and mineral research Vol. 14; no. 11; pp. 1880 - 1890
Main Authors:	Breckon, Jeremy J. W., Papaioannou, Stelios, Kon, Luke W. M., Tumber, Anthony, Hembry, Rosalind M., Murphy, Gillian, Reynolds, John J., Meikle, Murray C.
Format:	Journal Article
Language:	English
Published:	Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01-11-1999 American Society for Bone and Mineral Research
Subjects:	Animals Biological and medical sciences Blotting, Northern - methods Cells, Cultured Collagenases - analysis Collagenases - genetics Diseases of the osteoarticular system Estrogens - metabolism Femur Head - cytology Femur Head - pathology Lumbar Vertebrae - cytology Lumbar Vertebrae - pathology Matrix Metalloproteinase 2 - analysis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 3 - analysis Matrix Metalloproteinase 3 - biosynthesis Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 9 - analysis Matrix Metalloproteinase 9 - genetics matrix metalloproteinases Medical sciences Mice Osteoblasts - cytology Osteoblasts - metabolism Osteoporosis. Osteomalacia. Paget disease Ovariectomy Reverse Transcriptase Polymerase Chain Reaction - methods Space life sciences Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-2 - genetics tissue inhibitors of matrix metalloproteinases Up-Regulation Enzyme Pathogenesis Deficiency Estrogen Rodentia Diseases of the osteoarticular system 17β-Estradiol Enzyme inhibitor Metalloendopeptidases Bone disease Biosynthesis Gene expression Ovarian hormone Osteoarticular system Peptidases Osteoporosis Vertebrata Mammalia Mouse Animal Osteoblast Hydrolases Bone Sex steroid hormone
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