Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents

[Display omitted] In this work, we developed imidazole nucleoside derivatives with anti-dengue virus (DENV) activity was examined. First, compounds in a nucleosides library were screened to find lead compounds which inhibit replication of DENV. As a result, 5-ethynyl-(1-β-d-ribofuranosyl)imidazole-4...

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Bibliographic Details

Published in:	Bioorganic & medicinal chemistry Vol. 27; no. 11; pp. 2181 - 2186
Main Authors:	Okano, Yuki, Saito-Tarashima, Noriko, Kurosawa, Madoka, Iwabu, Ai, Ota, Masashi, Watanabe, Tadashi, Kato, Fumihiro, Hishiki, Takayuki, Fujimuro, Masahiro, Minakawa, Noriaki
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2019
Subjects:	4′-Seleno-modification 4′-Thio-modification Antiviral activity Dengue virus Imidazole nucleoside Imidazole nucleoside 4′-Seleno-modification Dengue virus 4′-Thio-modification Antiviral activity
Online Access:	Get full text
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