Diabetic peripheral neuropathy: amelioration of pain with transcutaneous electrostimulation

• Published in: Diabetes care Vol. 20; no. 11; pp. 1702 - 1705
• Main Authors: KUMAR, D, MARSHALL, H. J
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01-11-1997
• Subjects: Adult; Aged; Analgesics; Angina pectoris; Biological and medical sciences; Cohort Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes. Impaired glucose tolerance; Diabetic Neuropathies - complications; Diabetic Neuropathies - therapy; Diabetic neuropathy; Electrodes; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Male; Management. Various non-drug treatments. Langerhans islet grafts; Medical sciences; Middle Aged; Pain; Pain - etiology; Pain Management; Pain Measurement; Patients; Peripheral Nervous System - physiopathology; Peripheral Nervous System Diseases - complications; Peripheral Nervous System Diseases - therapy; Peripheral neuropathy; Research design; Single-Blind Method; Transcutaneous Electric Nerve Stimulation - standards; Transcutaneous electrical nerve stimulation-TENS; Endocrinopathy; Human; Nervous system diseases; Pain; Treatment; Electrotherapy; Diabetes mellitus; Treatment efficiency; Electrical stimulus; Complication; Peripheral nerve disease; Peripheral neuropathy
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.20.11.1702

Diabetic peripheral neuropathy: amelioration of pain with transcutaneous electrostimulation.
D Kumar and
H J Marshall
Department of Medicine, Los Angeles County University of Southern California Medical Center 90033, USA.
Abstract
OBJECTIVE: To evaluate the efficacy of transcutaneous electrotherapy for chronic painful peripheral neuropathy in patients
with type 2 diabetes. RESEARCH DESIGN AND METHODS: Thirty-one patients with symptoms and signs of peripheral neuropathy were
randomized to the electrotherapy or sham treatment (control) group. The electrostimulation was given by a portable unit (H-Wave
machine) than generated a biphasic, exponentially decaying waveform (pulse width 4 ms, 25-35 V, > or = 2 Hz). Patients treated
each of their lower extremities for 30 min daily for 4 weeks at home. Nine patients from the sham-treatment group participated
for a second period, during which all of them received the active electrotherapy. Patient's degree of pain and discomfort
was graded on a scale of 0 to 5. RESULTS: In the sham-treated group (n = 13), the neuropathic symptoms improved in five (38%)
patients, and the pain score declined from 2.92 +/- 0.13 to 2.38 +/- 0.26 (P < 0.04), suggesting a procedure-related placebo
effect. In the electrotherapy group (n = 18), symptomatic improvement was seen in 15 (83%) cases, 3 of which were completely
asymptomatic; the pain score declined from 3.17 +/- 0.12 to 1.44 +/- 0.25 (P < 0.01) and the posttreatment pain scores were
considerably lower (P < 0.03), indicating a substantial treatment effect over and above any placebo influence. Patients in
the electrotherapy group reported greater reduction in symptoms (52 +/- 7% vs. 27 +/- 10% in control subjects, P < 0.05) on
an analog scale. Moreover, the electrotherapy decreased pain scores (from 3.0 +/- 0.62 to 1.56 +/- 0.32, P < 0.02) in nine
patients who had received sham treatment earlier. CONCLUSIONS: A form of transcutaneous electrotherapy ameliorated the pain
and discomfort associated with peripheral neuropathy. This novel modality offers a potential non-pharmacological treatment
option.