A Calcium Pump in Vascular Smooth Muscle

A microsomal cell fraction derived from the intimal-medial layer of rabbit aorta takes up calcium in the presence of magnesium and adenosine triphosphate. The rate of uptake of calcium is slower than that observed in skeletal muscle microsomes. Uptake of calcium by mitochondria from the aorta is eve...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 176; no. 4032; pp. 305 - 306
Main Authors:	Fitzpatrick, David F., Landon, Erwin J., Debbas, Gamil, Hurwitz, Leon
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 21-04-1972
Subjects:	Adenosine Triphosphate - metabolism Animals Aorta Aorta - cytology Aorta - metabolism Calcium Calcium - metabolism Calcium Isotopes Cell Fractionation Diploidy Kinetics Magnesium - metabolism Microscopy, Electron Microsomes Microsomes - metabolism Muscle tonus Muscle, Smooth - metabolism Muscles Ova Rabbits Smooth muscle Spermatozoa Triploidy
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Summary:	A microsomal cell fraction derived from the intimal-medial layer of rabbit aorta takes up calcium in the presence of magnesium and adenosine triphosphate. The rate of uptake of calcium is slower than that observed in skeletal muscle microsomes. Uptake of calcium by mitochondria from the aorta is even more limited and, unlike microsomal uptake, is inhibited by azide.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.176.4032.305