Non-endothelial cell endothelin-B receptors limit neointima formation following vascular injury

The potent vasoconstrictor endothelin-1 (ET-1), acting on the endothelin-A (ETA) receptor, promotes intimal lesion formation following vascular injury. The endothelin-B (ETB) receptor, which mediates nitric oxide release and ET-1 clearance in endothelial cells, may moderate lesion formation, but thi...

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Bibliographic Details

Published in:	Cardiovascular research Vol. 95; no. 1; pp. 19 - 28
Main Authors:	KIRKBY, Nicholas S, DUTHIE, Karolina M, MILLER, Eileen, KOTELEVTSEV, Yuri V, BAGNALL, Alan J, WEBB, David J, HADOKE, Patrick W. F
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-07-2012
Subjects:	Animals Blood Pressure - drug effects Endothelin B Receptor Antagonists Endothelin-1 - pharmacology Male Mice Mice, Inbred C57BL Neointima - prevention & control Pyrrolidines - pharmacology Receptor, Endothelin A - physiology Receptor, Endothelin B - physiology Vascular System Injuries - pathology
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