The relationships among hemostatic markers, the withdrawal of fondaparinux due to a reduction in hemoglobin and deep vein thrombosis in Japanese patients undergoing major orthopedic surgery

• Published in: Clinica chimica acta Vol. 425; pp. 109 - 113
• Main Authors: Hasegawa, Masahiro, Wada, Hideo, Wakabayashi, Hiroki, Yoshida, Kakunoshin, Miyamoto, Noriki, Asanuma, Kunihiro, Matsumoto, Takeshi, Ohishi, Kohshi, Shimokariya, Yuji, Yamada, Norikazu, Uchida, Atsumasa, Sudo, Akihiro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 21-10-2013
• Subjects: Age Factors; Aged; Aged, 80 and over; Anemia - blood; Anemia - chemically induced; Anemia - pathology; Anti-Xa activity; Anticoagulants - adverse effects; Arthroplasty, Replacement, Knee; Biomarkers - blood; Deep vein thrombosis (DVT); Factor Xa - metabolism; Factor Xa Inhibitors; Female; Fibrin - metabolism; Fibrin Fibrinogen Degradation Products - metabolism; Fibrinogen - metabolism; Fondaparinux; Hemoglobins - metabolism; Humans; Male; Middle Aged; Orthopedic surgery; Polysaccharides - adverse effects; Risk Factors; Venous Thrombosis - blood; Venous Thrombosis - drug therapy; Venous Thrombosis - pathology; Withdrawal; Deep vein thrombosis (DVT); Anti-Xa activity; Orthopedic surgery; Withdrawal; Fondaparinux
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2013.07.009

The relationships among the hemostatic markers, the development of deep vein thrombosis (DVT) and the withdrawal of fondaparinux due to a reduction in the hemoglobin levels were examined.
Two-hundred twenty-one Japanese patients who underwent major orthopedic surgery and were treated with 1.5mg of fondaparinux instead of 2.5mg of fondaparinux were studied. Forty-seven of 221 patients discontinued fondaparinux treatment (withdrawal group) and 37 patients developed DVT.
The age, frequency of total knee arthroplasty (TKA), withdrawal of fondaparinux, reduction of hemoglobin and the plasma levels of soluble fibrin (SF), D-dimer and fibrinogen and fibrin degradation product (FDP) on day 1 after the operation were significantly higher in the patients with DVT. Elevated SF, D-dimer or FDP levels were associated with the risk for DVT. The age, frequency of TKA or DVT, anti-Xa activity and the creatinine, FDP and D-dimer levels were significantly higher in the withdrawal group. An anti-Xa level >0.33mg/l and an elevated D-dimer or FDP level were associated with the risk of withdrawal.
The age and SF levels, TKA and withdrawal of fondaparinux were related to the risk of DVT, and the anti-Xa activity, creatinine level and DVT were related to the risk of withdrawal of fondaparinux due to a reduction in hemoglobin.
•The withdrawal of fondaparinux and TKA were related to the risk of DVT.•The elevated age and SF levels were related to the risk of DVT.•The anti-Xa activities were related to the risk of reduction in hemoglobin.•FDP and D-dimer levels were significantly high in the withdrawal group.