Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha‐1 antitrypsin via inhibition of bad

Z alpha‐1 antitrypsin (AAT) deficiency is a genetic disease associated with accumulation of misfolded AAT in the endoplasmic reticulum (ER) of hepatocytes. ZAAT‐expressing cells display ER stress responses including nuclear factor kappaB activation and apoptosis. Using an in vitro model of ZAAT ER a...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 46; no. 2; pp. 496 - 503
Main Authors:	Miller, Stanley D.W., Greene, Catherine M., McLean, Caitriona, Lawless, Matthew W., Taggart, Clifford C., O'Neill, Shane J., McElvaney, Noel G.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-08-2007 Wiley
Subjects:	alpha 1-Antitrypsin - physiology Apoptosis - drug effects bcl-Associated Death Protein - antagonists & inhibitors bcl-Associated Death Protein - metabolism Biological and medical sciences Caspase 3 - metabolism Caspases, Initiator - physiology Cells, Cultured Cytochromes c - secretion Errors of metabolism Humans Medical sciences Metabolic diseases Phosphatidylinositol 3-Kinases - physiology Phosphorylation Proteins and glycoproteins Taurochenodeoxycholic Acid - pharmacology Prognosis Enzyme Pathogenesis Glycoprotein Caspase Metabolic diseases Hepatic disease Tauroursodeoxycholic acid Enzymopathy In vitro Survival Stress α1-Antitrypsin Genetic disease Peptidases Treatment Digestive diseases Hydrolases α1-Antitrypsine deficiency Apoptosis
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