Establishment and characterization of a MALT lymphoma cell line carrying an API2‐MALT1 translocation
MALT lymphomas with API2(BIRC3)‐MALT1 translocation usually have an indolent clinical course and rarely transform into aggressive lymphoma, and there have been no lymphoma cell lines carrying API2‐MALT1 translocation reported to date. We established a novel lymphoma cell line named BMA19, carrying t...
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| Published in: | Genes chromosomes & cancer Vol. 59; no. 9; pp. 517 - 524 |
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| Abstract | MALT lymphomas with API2(BIRC3)‐MALT1 translocation usually have an indolent clinical course and rarely transform into aggressive lymphoma, and there have been no lymphoma cell lines carrying API2‐MALT1 translocation reported to date. We established a novel lymphoma cell line named BMA19, carrying the API2‐MALT1 translocation from a patient with histologic transformation of intestinal MALT lymphoma. The cells were suggested to carry API2‐MALT1 and MYC‐IGH translocations by chromosomal analysis, and these translocations were confirmed by polymerase chain reaction analysis. The expression of MYC was shown to be enhanced as a result of the MYC‐IGH translocation, and it is considered to have played a role in the histologic transformation of MALT lymphoma. Whole exome sequencing of BMA19 identified several nucleotide variations in genes reported to be mutated in previous studies of marginal zone lymphomas. The MALT1 inhibitor MI‐2 specifically decreased cell growth, and the BMA19 cell line was suggested to be still dependent on the API2‐MALT1 signal. Subtractive microarray analysis showed that one of the earliest events resulting from MALT1 inhibition is increased susceptibility to endoplasmic reticulum stress‐induced apoptosis. The BMA19 cell line is considered to conserve the biological properties of MALT lymphoma and is expected to be a valuable tool for research into the pathogenesis of MALT lymphoma with an API2‐MALT1 translocation. |
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| AbstractList | MALT lymphomas with API2(BIRC3)‐MALT1 translocation usually have an indolent clinical course and rarely transform into aggressive lymphoma, and there have been no lymphoma cell lines carrying API2‐MALT1 translocation reported to date. We established a novel lymphoma cell line named BMA19, carrying the API2‐MALT1 translocation from a patient with histologic transformation of intestinal MALT lymphoma. The cells were suggested to carry API2‐MALT1 and MYC‐IGH translocations by chromosomal analysis, and these translocations were confirmed by polymerase chain reaction analysis. The expression of MYC was shown to be enhanced as a result of the MYC‐IGH translocation, and it is considered to have played a role in the histologic transformation of MALT lymphoma. Whole exome sequencing of BMA19 identified several nucleotide variations in genes reported to be mutated in previous studies of marginal zone lymphomas. The MALT1 inhibitor MI‐2 specifically decreased cell growth, and the BMA19 cell line was suggested to be still dependent on the API2‐MALT1 signal. Subtractive microarray analysis showed that one of the earliest events resulting from MALT1 inhibition is increased susceptibility to endoplasmic reticulum stress‐induced apoptosis. The BMA19 cell line is considered to conserve the biological properties of MALT lymphoma and is expected to be a valuable tool for research into the pathogenesis of MALT lymphoma with an API2‐MALT1 translocation. MALT lymphomas with API2(BIRC3)‐MALT1 translocation usually have an indolent clinical course and rarely transform into aggressive lymphoma, and there have been no lymphoma cell lines carrying API2‐MALT1 translocation reported to date. We established a novel lymphoma cell line named BMA19, carrying the API2‐MALT1 translocation from a patient with histologic transformation of intestinal MALT lymphoma. The cells were suggested to carry API2‐MALT1 and MYC‐IGH translocations by chromosomal analysis, and these translocations were confirmed by polymerase chain reaction analysis. The expression of MYC was shown to be enhanced as a result of the MYC‐IGH translocation, and it is considered to have played a role in the histologic transformation of MALT lymphoma. Whole exome sequencing of BMA19 identified several nucleotide variations in genes reported to be mutated in previous studies of marginal zone lymphomas. The MALT1 inhibitor MI‐2 specifically decreased cell growth, and the BMA19 cell line was suggested to be still dependent on the API2‐MALT1 signal. Subtractive microarray analysis showed that one of the earliest events resulting from MALT1 inhibition is increased susceptibility to endoplasmic reticulum stress‐induced apoptosis. The BMA19 cell line is considered to conserve the biological properties of MALT lymphoma and is expected to be a valuable tool for research into the pathogenesis of MALT lymphoma with an API2‐MALT1 translocation. |
| Author | Otsuka, Yasuyuki Nakao, Kensuke Takaori‐Kondo, Akifumi Izumi, Kiyotaka Nishikori, Momoko Yuan, Hepei |
| Author_xml | – sequence: 1 givenname: Kiyotaka surname: Izumi fullname: Izumi, Kiyotaka organization: Graduate School of Medicine, Kyoto University – sequence: 2 givenname: Momoko orcidid: 0000-0003-4171-2162 surname: Nishikori fullname: Nishikori, Momoko email: nishikor@kuhp.kyoto-u.ac.jp organization: Graduate School of Medicine, Kyoto University – sequence: 3 givenname: Hepei surname: Yuan fullname: Yuan, Hepei organization: Graduate School of Medicine, Kyoto University – sequence: 4 givenname: Yasuyuki surname: Otsuka fullname: Otsuka, Yasuyuki organization: Graduate School of Medicine, Kyoto University – sequence: 5 givenname: Kensuke surname: Nakao fullname: Nakao, Kensuke organization: Graduate School of Medicine, Kyoto University – sequence: 6 givenname: Akifumi surname: Takaori‐Kondo fullname: Takaori‐Kondo, Akifumi organization: Graduate School of Medicine, Kyoto University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32348592$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/j.1349-7006.2002.tb01306.x 10.3324/haematol.2018.214957 10.1111/j.1349-7006.2003.tb01518.x 10.1038/nrc3748 10.1158/0008-5472.CAN-17-2485 10.1158/1078-0432.CCR-15-2296 10.1016/S0002-9440(10)64157-0 10.1016/S0002-9440(10)64988-7 10.1097/MOH.0000000000000051 10.1016/j.molimm.2020.01.006 10.1016/j.semcancer.2013.11.005 10.1182/blood.V88.3.985.bloodjournal883985 10.1046/j.1365-2141.2003.04035.x 10.1126/science.1198946 10.1038/onc.2014.186 10.1182/blood.V95.3.802.003k19_802_806 10.1016/S1074-7613(03)00029-3 10.1038/nm.3884 10.1016/S0002-9440(10)65012-2 10.1007/s12185-019-02810-y 10.1038/nprot.2008.211 10.1101/gad.871201 10.1182/blood-2002-11-3502 10.1084/jem.20120904 10.1074/jbc.271.10.5513 10.1016/S0002-9440(10)64948-6 10.1016/j.ccr.2012.11.003 10.1002/(SICI)1096-9896(199704)181:4<381::AID-PATH787>3.0.CO;2-I 10.1371/journal.pone.0083244 10.1038/nrc1409 10.1074/jbc.M009984200 10.1093/nar/gkq603 10.1093/nar/gkn923 |
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| Keywords | MALT lymphoma microarray analysis API2-MALT1 cell line MALT1 inhibitor |
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| References | 2015; 34 2010; 38 2004; 4 2019; 104 2000; 95 2014; 24 2003; 18 1997; 181 2000; 156 2003; 94 2013; 8 2011; 331 2014; 21 2012; 209 2001; 276 2002; 161 2017; 77 1997; 57 2015; 21 1996; 271 2014; 14 2020; 111 2001; 15 2002; 93 2009; 4 2003; 102 2012; 22 2020; 119 2009; 37 2003; 120 1996; 88 2016; 22 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 Ott G (e_1_2_8_27_1) 1997; 57 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_15_1 e_1_2_8_16_1 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1 |
| References_xml | – volume: 21 start-page: 309 issue: 4 year: 2014 end-page: 319 article-title: The origin and targeting of mucosa‐associated lymphoid tissue lymphomas publication-title: Curr Opin Hematol – volume: 77 start-page: 7038 issue: 24 year: 2017 end-page: 7048 article-title: MALT1 inhibition is efficacious in both naive and ibrutinib‐resistant chronic lymphocytic leukemia publication-title: Cancer Res – volume: 21 start-page: 922 issue: 8 year: 2015 end-page: 926 article-title: Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma publication-title: Nat Med – volume: 4 start-page: 44 issue: 1 year: 2009 end-page: 57 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nat Protoc – volume: 119 start-page: 35 year: 2020 end-page: 45 article-title: EZH2 inhibitors restore epigenetically silenced CD58 expression in B‐cell lymphomas publication-title: Mol Immunol – volume: 111 start-page: 724 issue: 5 year: 2020 end-page: 732 article-title: Histologic transformation of t(11;18)‐positive MALT lymphoma presented with aberrant T‐cell marker expression publication-title: Int J Hematol – volume: 4 start-page: 644 issue: 8 year: 2004 end-page: 653 article-title: MALT lymphoma: from morphology to molecules publication-title: Nat Rev Cancer – volume: 94 start-page: 774 issue: 9 year: 2003 end-page: 781 article-title: Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B‐cell lymphoma publication-title: Cancer Sci – volume: 93 start-page: 677 issue: 6 year: 2002 end-page: 684 article-title: Clinicopathologic comparison between the API2‐MALT1 chimeric transcript‐positive and ‐negative gastric low‐grade B‐cell lymphoma of mucosa‐associated lymphoid tissue type publication-title: Jpn J Cancer Res – volume: 34 start-page: 2406 issue: 18 year: 2015 end-page: 2409 article-title: A common functional consequence of tumor‐derived mutations within c‐MYC publication-title: Oncogene – volume: 22 start-page: 3593 issue: 14 year: 2016 end-page: 3605 article-title: Clinical and biologic significance of MYC genetic mutations in de novo diffuse large B‐cell lymphoma publication-title: Clin Cancer Res – volume: 38 issue: 16 year: 2010 article-title: ANNOVAR: functional annotation of genetic variants from high‐throughput sequencing data publication-title: Nucleic Acids Res – volume: 57 start-page: 3944 issue: 18 year: 1997 end-page: 3948 article-title: The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low‐grade but not high‐grade malignant non‐Hodgkin's lymphomas of the mucosa‐associated lymphoid tissue (MALT‐) type publication-title: Cancer Res – volume: 156 start-page: 1433 issue: 4 year: 2000 end-page: 1439 article-title: The product of the t(11;18), an API2‐MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation publication-title: Am J Pathol – volume: 14 start-page: 502 issue: 7 year: 2014 end-page: 509 article-title: New PARP targets for cancer therapy publication-title: Nat Rev Cancer – volume: 120 start-page: 97 issue: 1 year: 2003 end-page: 100 article-title: High frequency of t(11;18) in gastric mucosa‐associated lymphoid tissue lymphomas in Taiwan, including one patient with high‐grade transformation publication-title: Br J Haematol – volume: 18 start-page: 301 issue: 2 year: 2003 end-page: 312 article-title: Regulation of marginal zone B cell development by MINT, a suppressor of notch/RBP‐J signaling pathway publication-title: Immunity – volume: 271 start-page: 5513 issue: 10 year: 1996 end-page: 5518 article-title: Functional analysis of Burkitt's lymphoma mutant c‐Myc proteins publication-title: J Biol Chem – volume: 102 start-page: 1012 issue: 3 year: 2003 end-page: 1018 article-title: Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma publication-title: Blood – volume: 331 start-page: 468 issue: 6016 year: 2011 end-page: 472 article-title: Cleavage of NIK by the API2‐MALT1 fusion oncoprotein leads to noncanonical NF‐kappaB activation publication-title: Science – volume: 15 start-page: 1140 issue: 9 year: 2001 end-page: 1151 article-title: Sharp, an inducible cofactor that integrates nuclear receptor repression and activation publication-title: Genes Dev – volume: 181 start-page: 381 issue: 4 year: 1997 end-page: 386 article-title: c‐myc gene abnormalities in mucosa‐associated lymphoid tissue (MALT) lymphomas publication-title: J Pathol – volume: 8 issue: 12 year: 2013 article-title: Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma publication-title: PLoS One – volume: 88 start-page: 985 issue: 3 year: 1996 end-page: 994 article-title: Application of long‐distance polymerase chain reaction to detection of junctional sequences created by chromosomal translocation in mature B‐cell neoplasms publication-title: Blood – volume: 156 start-page: 1183 issue: 4 year: 2000 end-page: 1188 article-title: Incidence and subtype specificity of API2‐MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas publication-title: Am J Pathol – volume: 95 start-page: 802 issue: 3 year: 2000 end-page: 806 article-title: Mucosa‐associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed publication-title: Blood – volume: 209 start-page: 1537 issue: 9 year: 2012 end-page: 1551 article-title: The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development publication-title: J Exp Med – volume: 22 start-page: 812 issue: 6 year: 2012 end-page: 824 article-title: MALT1 small molecule inhibitors specifically suppress ABC‐DLBCL in vitro and in vivo publication-title: Cancer Cell – volume: 161 start-page: 63 issue: 1 year: 2002 end-page: 71 article-title: Mucosa‐associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa‐associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways publication-title: Am J Pathol – volume: 156 start-page: 807 issue: 3 year: 2000 end-page: 812 article-title: API2‐MALT1 chimeric transcripts involved in mucosa‐associated lymphoid tissue type lymphoma predict heterogeneous products publication-title: Am J Pathol – volume: 104 start-page: e558 issue: 12 year: 2019 end-page: e561 article-title: Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses publication-title: Haematologica – volume: 24 start-page: 33 year: 2014 end-page: 42 article-title: Chronic inflammation and extra‐nodal marginal‐zone lymphomas of MALT‐type publication-title: Semin Cancer Biol – volume: 276 start-page: 19012 issue: 22 year: 2001 end-page: 19019 article-title: Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF‐kappa B signaling pathway publication-title: J Biol Chem – volume: 37 start-page: 1 issue: 1 year: 2009 end-page: 13 article-title: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists publication-title: Nucleic Acids Res – ident: e_1_2_8_10_1 doi: 10.1111/j.1349-7006.2002.tb01306.x – ident: e_1_2_8_20_1 doi: 10.3324/haematol.2018.214957 – ident: e_1_2_8_12_1 doi: 10.1111/j.1349-7006.2003.tb01518.x – ident: e_1_2_8_24_1 doi: 10.1038/nrc3748 – ident: e_1_2_8_34_1 doi: 10.1158/0008-5472.CAN-17-2485 – ident: e_1_2_8_22_1 doi: 10.1158/1078-0432.CCR-15-2296 – ident: e_1_2_8_7_1 doi: 10.1016/S0002-9440(10)64157-0 – ident: e_1_2_8_30_1 doi: 10.1016/S0002-9440(10)64988-7 – ident: e_1_2_8_4_1 doi: 10.1097/MOH.0000000000000051 – ident: e_1_2_8_13_1 doi: 10.1016/j.molimm.2020.01.006 – ident: e_1_2_8_3_1 doi: 10.1016/j.semcancer.2013.11.005 – ident: e_1_2_8_11_1 doi: 10.1182/blood.V88.3.985.bloodjournal883985 – ident: e_1_2_8_6_1 doi: 10.1046/j.1365-2141.2003.04035.x – ident: e_1_2_8_35_1 doi: 10.1126/science.1198946 – ident: e_1_2_8_21_1 doi: 10.1038/onc.2014.186 – ident: e_1_2_8_25_1 doi: 10.1182/blood.V95.3.802.003k19_802_806 – ident: e_1_2_8_16_1 doi: 10.1016/S1074-7613(03)00029-3 – ident: e_1_2_8_33_1 doi: 10.1038/nm.3884 – volume: 57 start-page: 3944 issue: 18 year: 1997 ident: e_1_2_8_27_1 article-title: The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low‐grade but not high‐grade malignant non‐Hodgkin's lymphomas of the mucosa‐associated lymphoid tissue (MALT‐) type publication-title: Cancer Res contributor: fullname: Ott G – ident: e_1_2_8_28_1 doi: 10.1016/S0002-9440(10)65012-2 – ident: e_1_2_8_8_1 doi: 10.1007/s12185-019-02810-y – ident: e_1_2_8_14_1 doi: 10.1038/nprot.2008.211 – ident: e_1_2_8_17_1 doi: 10.1101/gad.871201 – ident: e_1_2_8_31_1 doi: 10.1182/blood-2002-11-3502 – ident: e_1_2_8_18_1 doi: 10.1084/jem.20120904 – ident: e_1_2_8_23_1 doi: 10.1074/jbc.271.10.5513 – ident: e_1_2_8_29_1 doi: 10.1016/S0002-9440(10)64948-6 – ident: e_1_2_8_32_1 doi: 10.1016/j.ccr.2012.11.003 – ident: e_1_2_8_26_1 doi: 10.1002/(SICI)1096-9896(199704)181:4<381::AID-PATH787>3.0.CO;2-I – ident: e_1_2_8_19_1 doi: 10.1371/journal.pone.0083244 – ident: e_1_2_8_2_1 doi: 10.1038/nrc1409 – ident: e_1_2_8_5_1 doi: 10.1074/jbc.M009984200 – ident: e_1_2_8_9_1 doi: 10.1093/nar/gkq603 – ident: e_1_2_8_15_1 doi: 10.1093/nar/gkn923 |
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| Snippet | MALT lymphomas with API2(BIRC3)‐MALT1 translocation usually have an indolent clinical course and rarely transform into aggressive lymphoma, and there have been... MALT lymphomas with API2(BIRC3)-MALT1 translocation usually have an indolent clinical course and rarely transform into aggressive lymphoma, and there have been... MALT lymphomas with API2(BIRC3)‐MALT1 translocation usually have an indolent clinical course and rarely transform into aggressive lymphoma, and there have been... |
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| SubjectTerms | API2‐MALT1 Apoptosis cell line Chromosome translocations Endoplasmic reticulum Genetic transformation Heavy chains Immunoglobulins Intestine Lymphoma MALT lymphoma MALT1 inhibitor microarray analysis Mucosal-associated lymphoid tissue Myc protein Polymerase chain reaction Tumor cell lines |
| Title | Establishment and characterization of a MALT lymphoma cell line carrying an API2‐MALT1 translocation |
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