Plaque morphology predictors of side branch occlusion after provisional stenting in coronary bifurcation lesion: Results of optical coherence tomography bifurcation study (ORBID)

• Published in: Catheterization and cardiovascular interventions Vol. 89; no. 2; pp. 259 - 268
• Main Authors: Kini, Annapoorna S., Vengrenyuk, Yuliya, Pena, Jacobo, Yoshimura, Takahiro, Panwar, Sadik R., Motoyama, Sadako, Kezbor, Safwan, Hasan, Choudhury M., Palkhiwala, Sameet, Kovacic, Jason C., Moreno, Pedro, Baber, Usman, Mehran, Roxana, Narula, Jagat, Sharma, Samin K.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-02-2017
• Subjects: Aged; bifurcation lesion; Chi-Square Distribution; Coronary Angiography; coronary artery disease; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - metabolism; Coronary Artery Disease - pathology; Coronary Artery Disease - therapy; Coronary Occlusion - diagnostic imaging; Coronary Occlusion - etiology; Coronary Occlusion - pathology; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - metabolism; Coronary Stenosis - pathology; Coronary Stenosis - therapy; Coronary Vessels - chemistry; Coronary Vessels - diagnostic imaging; Coronary Vessels - pathology; Drug-Eluting Stents; Female; Humans; Lipids - analysis; Logistic Models; Male; Middle Aged; Multivariate Analysis; New York City; Odds Ratio; optical coherence tomography; Percutaneous Coronary Intervention - adverse effects; Percutaneous Coronary Intervention - instrumentation; Plaque, Atherosclerotic; Predictive Value of Tests; Prospective Studies; provisional stenting; Risk Factors; side branch occlusion; Time Factors; Tomography, Optical Coherence; Treatment Outcome; coronary artery disease; optical coherence tomography; provisional stenting; side branch occlusion; bifurcation lesion
• ISSN: 1522-1946; 1522-726X
• DOI: 10.1002/ccd.26524

Objectives
The aim of this study was to identify the predictors of side branch (SB) ostial stenosis developed after provisional stenting of the main vessel (MV) using optical coherence tomography (OCT).
Background
Provisional stenting remains the main approach to treatment of bifurcation lesions; however, it may result in the narrowing of SB ostium. There is little information about underlying plaque morphology of the MV lesion and its potential impact on the SB after provisional stenting.
Methods
Patients with stable coronary disease with angiographic MV lesion not involving SB were included in a prospective single center study. The primary outcome was significant SB ostium stenosis (SBOS), defined as residual stenosis of >50% after MV stenting.
Results
Thirty bifurcation lesions in 30 patients were analyzed in the study. Poststenting significant SBOS was observed in 30% of patients. The MV lesions with SBOS > 50% were characterized by a higher prevalence of lipid rich plaques (100 vs. 64%, p = 0.040) and spotty calcifications (60 vs. 0%, p = 0.005). Maximal lipid arcs were greater (257° vs. 132°, p = 0.001) and lipid volume index was higher (1380 vs. 574, p = 0.012) in the SBOS >50% group. Multivariate logistic regression analysis identified maximal lipid arc (odds ratio (OR): 1.014, p = 0.038) and the presence of lipid plaque contralateral to SB ostium (OR: 8.14, p = 0.046) before stenting as independent predictors of significant SBOS after PCI.
Conclusions
High lipid content of the MV lesion and a contralateral location of lipid in the bifurcation area may contribute to SBOS after provisional stenting. © 2016 Wiley Periodicals, Inc.