Modification of the cysteamine side chain of thienamycin. III

Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 40; no. 9; p. 1292
Main Authors:	Sato, M, Takemura, M, Atarashi, S, Higashi, K, Nagahara, T, Furukawa, M, Ikeuchi, T, Osada, Y
Format:	Journal Article
Language:	English
Published:	Japan 01-01-1987
Subjects:	Chemical Phenomena Chemistry, Physical Chromatography, High Pressure Liquid Cysteamine Dipeptidases - metabolism Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Imipenem Microbial Sensitivity Tests Structure-Activity Relationship Thienamycins - pharmacology
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Description
Summary:	Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.40.1292