Global prevalence of pre-existing HCV variants resistant to direct-acting antiviral agents (DAAs): mining the GenBank HCV genome data

Direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) proteins open a whole new era for anti-HCV therapy, but DAA resistance associated variants (RAVs) could jeopardize the effectiveness of DAAs. We reported the global prevalence of DAA RAVs using published GenBank data. 58.7% of seq...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 20310
Main Authors:	Chen, Zhi-wei, Li, Hu, Ren, Hong, Hu, Peng
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04-02-2016 Nature Publishing Group
Subjects:	631/1647 692/4020 Antiviral agents Antiviral Agents - pharmacology Data processing Databases, Genetic Drug Resistance, Viral - drug effects Drug Resistance, Viral - genetics Gene Frequency Genomes Genotype Geography Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - metabolism Hepatitis C Hepatitis C - epidemiology Hepatitis C - virology Humanities and Social Sciences Humans Interferon multidisciplinary Prevalence Protease inhibitors Protease Inhibitors - pharmacology Proteinase inhibitors Science Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism
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