A Polymorphism in the Cytidine Deaminase Promoter Predicts Severe Capecitabine-Induced Hand-Foot Syndrome

Hand-foot syndrome (HFS) is one of the most relevant dose-limiting adverse effects of capecitabine, an oral prodrug of 5-fluorouracil used in the standard treatment of breast and colorectal cancer. We investigated the association between grade 3 HFS and genetic variations in genes involved in capeci...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 17; no. 7; pp. 2006 - 2013
Main Authors:	CARONIA, Daniela, MARTIN, Miguel, GONZALEZ-NEIRA, Anna, SASTRE, Javier, DE LA TORRE, Julio, ANGEL GARCIA-SAENZ, José, ALONSO, Maria R, MORENO, Leticia T, PITA, Guillermo, DIAZ-RUBIO, Eduardo, BENITEZ, Javier
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-04-2011
Subjects:	5-Fluorouracil Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - adverse effects Antineoplastic agents Base Sequence Binding Sites Biological and medical sciences Breast Neoplasms - drug therapy Capecitabine Cell Line, Tumor Colorectal Neoplasms - drug therapy Cytidine Deaminase - genetics Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Dermatology E2F Transcription Factors - metabolism Epstein-Barr virus Erythema - chemically induced Erythema - genetics Female Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Foot Dermatoses - chemically induced Foot Dermatoses - genetics Genetic Association Studies Genetic Predisposition to Disease Hand Dermatoses - chemically induced Hand Dermatoses - genetics Haplotypes Humans Logistic Models Male Medical sciences Middle Aged Pain - chemically induced Pharmacology. Drug treatments Polymorphism, Single Nucleotide Prodrugs - adverse effects Promoter Regions, Genetic Sequence Analysis, DNA Syndrome Transcription, Genetic Vascular disorders of the skin Antineoplastic agent Acrosyndrome Skin disease Genetic variability Enzyme Capecitabine Fluoropyrimidine derivatives Cardiovascular disease Genotype Prodrug Vascular disease Promoter Hydrolases Capillary vessel disease Erythromelalgia Predictive factor Pyrimidine nucleoside Cytidine deaminase Polymorphism
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