Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40

• Published in: Gynecological endocrinology Vol. 30; no. 4; pp. 311 - 315
• Main Authors: Aziz, M., Wissing, M. L. M., Naver, K. V., Faber, J., Skouby, S. O.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01-04-2014; Taylor & Francis
• Subjects: Adipokines - blood; Adolescent; Adult; Androgens; Biomarkers - blood; Body Mass Index; C-Reactive Protein - metabolism; Chitinase-3-Like Protein 1; Cross-Sectional Studies; Denmark; Female; Humans; Inflammation - blood; Insulin - blood; Insulin Resistance; Lectins - blood; low-grade inflammation; PCOS; Polycystic Ovary Syndrome - blood; Prospective Studies; Regression Analysis; Triglycerides - blood; Waist Circumference; Young Adult
• ISSN: 0951-3590; 1473-0766
• DOI: 10.3109/09513590.2013.879854

Abstract
Objective: To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP.
Design: Cross-sectional study.
Setting: Gynecological clinics at three Danish University Hospitals.
Patients: One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria.
Main outcome measures: Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR.
Results: No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40.
Conclusion: YKL-40, the marker of low-grade inflammation is not increased in women with PCOS.