Effect of different forms of tobacco on the oral microbiome in healthy adults: a systematic review

• Published in: Frontiers in oral health Vol. 5; p. 1310334
• Main Authors: Senaratne, Nikitha Lalindri Mareena, Yung On, Cheng, Shetty, Naresh Yedthare, Gopinath, Divya
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20-02-2024
• Subjects: chewers; microbiome; microbiota; oral; Oral Health; smokers; tobacco; microbiota; chewers; oral; tobacco; smokers; microbiome
• ISSN: 2673-4842; 2673-4842
• DOI: 10.3389/froh.2024.1310334

The study aimed to evaluate the impact of tobacco use on the composition and functions of the oral microbiome in healthy adult humans.
We conducted a systematic search on PubMed, Web of Science, and Cinhal databases for literature published until 15 December 2023, to identify studies that have evaluated the oral microbiome with culture-independent next-generation techniques comparing the oral microbiome of tobacco users and non-users. The search followed the PECO format. The outcomes included changes in microbial diversity and abundance of microbial taxa. The quality assessment was performed using the Newcastle-Ottawa Scale (NOS) (PROSPERO ID CRD42022340151).
Out of 2,435 articles screened, 36 articles satisfied the eligibility criteria and were selected for full-text review. Despite differences in design, quality, and population characteristics, most studies reported an increase in bacterial diversity and richness in tobacco users. The most notable bacterial taxa enriched in users were
and
at the phylum level and
,
, and
at the genus level. At the functional level, more similarities could be noted;
and
were increased in tobacco users compared to non-users. Most of the studies were of good quality on the NOS scale.
Tobacco smoking influences oral microbial community harmony, and it shows a definitive shift towards a proinflammatory milieu. Heterogeneities were detected due to sampling and other methodological differences, emphasizing the need for greater quality research using standardized methods and reporting.
CRD42022340151.