The Latoia consocia Caterpillar Induces Pain by Targeting Nociceptive Ion Channel TRPV1
Accidental contact with caterpillar bristles causes local symptoms such as severe pain, intense heat, edema, erythema, and pruritus. However, there is little functional evidence to indicate a potential mechanism. In this study, we analyzed the biological characteristics of the crude venom from the l...
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| Published in: | Toxins Vol. 11; no. 12; p. 695 |
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| Main Authors: | , , , , , , , , |
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| Abstract | Accidental contact with caterpillar bristles causes local symptoms such as severe pain, intense heat, edema, erythema, and pruritus. However, there is little functional evidence to indicate a potential mechanism. In this study, we analyzed the biological characteristics of the crude venom from the larval stage of
living in South-West China. Intraplantar injection of the venom into the hind paws of mice induced severe acute pain behaviors in wild type (WT) mice; the responses were much reduced in TRPV1-deficit (TRPV1 KO) mice. The TRPV1-specific inhibitor, capsazepine, significantly attenuated the pain behaviors. Furthermore, the crude venom evoked strong calcium signals in the dorsal root ganglion (DRG) neurons of WT mice but not those of TRPV1 KO mice. Among the pain-related ion channels we tested, the crude venom only activated the TRPV1 channel. To better understand the venom components, we analyzed the transcriptome of the
sebaceous gland region. Our study suggests that TRPV1 serves as a primary nociceptor in caterpillar-induced pain and forms the foundation for elucidating the pain-producing mechanism. |
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| AbstractList | Accidental contact with caterpillar bristles causes local symptoms such as severe pain, intense heat, edema, erythema, and pruritus. However, there is little functional evidence to indicate a potential mechanism. In this study, we analyzed the biological characteristics of the crude venom from the larval stage of
Latoia consocia
living in South-West China. Intraplantar injection of the venom into the hind paws of mice induced severe acute pain behaviors in wild type (WT) mice; the responses were much reduced in TRPV1-deficit (TRPV1 KO) mice. The TRPV1-specific inhibitor, capsazepine, significantly attenuated the pain behaviors. Furthermore, the crude venom evoked strong calcium signals in the dorsal root ganglion (DRG) neurons of WT mice but not those of TRPV1 KO mice. Among the pain-related ion channels we tested, the crude venom only activated the TRPV1 channel. To better understand the venom components, we analyzed the transcriptome of the
L. consocia
sebaceous gland region. Our study suggests that TRPV1 serves as a primary nociceptor in caterpillar-induced pain and forms the foundation for elucidating the pain-producing mechanism. Accidental contact with caterpillar bristles causes local symptoms such as severe pain, intense heat, edema, erythema, and pruritus. However, there is little functional evidence to indicate a potential mechanism. In this study, we analyzed the biological characteristics of the crude venom from the larval stage of Latoia consocia living in South-West China. Intraplantar injection of the venom into the hind paws of mice induced severe acute pain behaviors in wild type (WT) mice; the responses were much reduced in TRPV1-deficit (TRPV1 KO) mice. The TRPV1-specific inhibitor, capsazepine, significantly attenuated the pain behaviors. Furthermore, the crude venom evoked strong calcium signals in the dorsal root ganglion (DRG) neurons of WT mice but not those of TRPV1 KO mice. Among the pain-related ion channels we tested, the crude venom only activated the TRPV1 channel. To better understand the venom components, we analyzed the transcriptome of the L. consocia sebaceous gland region. Our study suggests that TRPV1 serves as a primary nociceptor in caterpillar-induced pain and forms the foundation for elucidating the pain-producing mechanism. Accidental contact with caterpillar bristles causes local symptoms such as severe pain, intense heat, edema, erythema, and pruritus. However, there is little functional evidence to indicate a potential mechanism. In this study, we analyzed the biological characteristics of the crude venom from the larval stage of living in South-West China. Intraplantar injection of the venom into the hind paws of mice induced severe acute pain behaviors in wild type (WT) mice; the responses were much reduced in TRPV1-deficit (TRPV1 KO) mice. The TRPV1-specific inhibitor, capsazepine, significantly attenuated the pain behaviors. Furthermore, the crude venom evoked strong calcium signals in the dorsal root ganglion (DRG) neurons of WT mice but not those of TRPV1 KO mice. Among the pain-related ion channels we tested, the crude venom only activated the TRPV1 channel. To better understand the venom components, we analyzed the transcriptome of the sebaceous gland region. Our study suggests that TRPV1 serves as a primary nociceptor in caterpillar-induced pain and forms the foundation for elucidating the pain-producing mechanism. |
| Author | Han, Yalan Tian, Yuhua Zheng, Jie Yao, Zhihao Kamau, Peter Muiruri Hu, Jingmei Lai, Ren Luo, Lei Luo, Anna |
| AuthorAffiliation | 7 KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of bioactive peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China 9 Center for Biosafety Mega-Science, Chinese Academy of Sciences, No.44, Xiaohongshan, Wuchang District/Huangjin Industrial Park, Zhengdian Street, Jiangxia District, Wuhan 430207, China 5 College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China 6 Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA 1 Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao 266000, China 4 Sino-African Joint Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3 University of Chinese Academy of Sciences, Beijing 100049, |
| AuthorAffiliation_xml | – name: 6 Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA – name: 5 College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China – name: 2 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of bioactive peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China – name: 8 Institute for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai 201203, China – name: 9 Center for Biosafety Mega-Science, Chinese Academy of Sciences, No.44, Xiaohongshan, Wuchang District/Huangjin Industrial Park, Zhengdian Street, Jiangxia District, Wuhan 430207, China – name: 4 Sino-African Joint Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China – name: 1 Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao 266000, China – name: 3 University of Chinese Academy of Sciences, Beijing 100049, China – name: 7 KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| Author_xml | – sequence: 1 givenname: Zhihao surname: Yao fullname: Yao, Zhihao organization: Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao 266000, China – sequence: 2 givenname: Peter Muiruri surname: Kamau fullname: Kamau, Peter Muiruri organization: Sino-African Joint Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China – sequence: 3 givenname: Yalan surname: Han fullname: Han, Yalan organization: University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 4 givenname: Jingmei surname: Hu fullname: Hu, Jingmei organization: College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China – sequence: 5 givenname: Anna surname: Luo fullname: Luo, Anna organization: University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 6 givenname: Lei surname: Luo fullname: Luo, Lei organization: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of bioactive peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China – sequence: 7 givenname: Jie orcidid: 0000-0002-4161-627X surname: Zheng fullname: Zheng, Jie organization: Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA – sequence: 8 givenname: Yuhua surname: Tian fullname: Tian, Yuhua organization: Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao 266000, China – sequence: 9 givenname: Ren surname: Lai fullname: Lai, Ren organization: Center for Biosafety Mega-Science, Chinese Academy of Sciences, No.44, Xiaohongshan, Wuchang District/Huangjin Industrial Park, Zhengdian Street, Jiangxia District, Wuhan 430207, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31783580$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00018_024_05318_9 crossref_primary_10_3389_fimmu_2022_972442 crossref_primary_10_1016_j_bcp_2023_115598 crossref_primary_10_1016_j_cbi_2020_109178 crossref_primary_10_1097_j_pain_0000000000002701 crossref_primary_10_3390_toxins12010015 crossref_primary_10_3390_insects12050396 crossref_primary_10_1080_15384101_2020_1831246 crossref_primary_10_3390_biomedicines8060143 crossref_primary_10_3390_toxins13060415 crossref_primary_10_3390_ijerph19042387 |
| Cites_doi | 10.1146/annurev-ento-120811-153650 10.1074/mcp.M112.018853 10.1016/j.cell.2010.03.052 10.3390/toxins9100326 10.1016/S0300-9084(00)01164-0 10.3390/toxins7114832 10.1016/j.pain.2013.12.030 10.1038/nrn3529 10.1016/j.tips.2016.05.002 10.1038/ncomms9297 10.1002/cphy.c120001 10.1007/s00441-005-0013-3 10.3390/toxins7093671 10.1073/pnas.1714760115 10.1073/pnas.1306285110 10.1038/s41467-019-09965-6 10.3390/toxins9110360 10.1016/j.toxicon.2003.09.003 10.1016/j.toxicon.2006.11.033 10.3390/toxins8010002 10.1016/j.mcn.2015.02.001 10.1016/j.toxicon.2018.04.011 10.1126/sciadv.1700810 10.4269/ajtmh.2005.72.347 10.1016/S0041-0101(01)00086-1 10.1016/j.toxicon.2003.12.003 10.1016/S0041-0101(01)00182-9 10.3390/toxins7030679 10.3390/toxins2122851 10.1146/annurev-cellbio-101011-155833 10.1016/j.toxicon.2018.08.007 |
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| Keywords | caterpillar Latoia consocia pain venom trpv1 |
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| Snippet | Accidental contact with caterpillar bristles causes local symptoms such as severe pain, intense heat, edema, erythema, and pruritus. However, there is little... |
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| SubjectTerms | Animals Annotations Bristles Calcium signalling Capsaicin receptors Capsazepine Caterpillars Dorsal root ganglia Edema Erythema Ion channels Nervous system Pain Pain perception Proteins Pruritus Rodents Sebaceous gland Sebaceous glands Transcriptomes Venom |
| Title | The Latoia consocia Caterpillar Induces Pain by Targeting Nociceptive Ion Channel TRPV1 |
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