Does neurofilament phosphorylation regulate axonal transport?
Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present eviden...
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| Published in: | Trends in neurosciences (Regular ed.) Vol. 26; no. 8; pp. 397 - 400 |
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01-08-2003
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| Abstract | Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport. |
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| AbstractList | Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport. |
| Author | Jung, Cheolwha Pant, Harish C Shea, Thomas B |
| Author_xml | – sequence: 1 givenname: Thomas B surname: Shea fullname: Shea, Thomas B email: thomas_shea@uml.edu organization: Center for Cellular Neurobiology and Neurodegeneration Research, Departments of Biological Sciences and Biochemistry, University of Massachusetts (Lowell), One University Avenue, Lowell, MA 01854, USA – sequence: 2 givenname: Cheolwha surname: Jung fullname: Jung, Cheolwha organization: Center for Cellular Neurobiology and Neurodegeneration Research, Departments of Biological Sciences and Biochemistry, University of Massachusetts (Lowell), One University Avenue, Lowell, MA 01854, USA – sequence: 3 givenname: Harish C surname: Pant fullname: Pant, Harish C organization: Center for Cellular Neurobiology and Neurodegeneration Research, Departments of Biological Sciences and Biochemistry, University of Massachusetts (Lowell), One University Avenue, Lowell, MA 01854, USA |
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| Cites_doi | 10.1083/jcb.200202037 10.1038/375061a0 10.1083/jcb.200303138 10.1002/(SICI)1097-0169(1999)42:3<230::AID-CM6>3.0.CO;2-A 10.1083/jcb.151.5.1013 10.1083/jcb.129.6.1629 10.1016/S0079-6603(08)60823-5 10.1034/j.1600-0854.2000.010610.x 10.1016/0092-8674(83)90189-7 10.1046/j.1471-4159.1999.0730972.x 10.1139/o95-063 10.1016/S0006-8993(99)02314-8 10.1083/jcb.107.6.2689 10.1523/JNEUROSCI.03-08-01694.1983 10.1016/S0166-2236(00)01919-6 10.1023/A:1010999509251 10.1083/jcb.135.3.711 10.1083/jcb.143.1.183 10.1002/1097-0169(200010)47:2<120::AID-CM3>3.0.CO;2-6 10.1016/S0955-0674(98)80090-2 |
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| Keywords | Axon Neurofilament Phosphorylation Stability Review Axoplasmic transport |
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| References | Jung, Shea (BIB11) 1999; 43 Sanchez (BIB18) 2000; 151 Pant, Veeranna (BIB4) 1995; 73 Marzalek (BIB12) 1996; 135 Shea, Flanagan (BIB17) 2001; 24 Collard (BIB10) 1995; 375 Lewis, Nixon (BIB9) 1988; 107 Jung (BIB6) 2000; 856 Hoffma (BIB5) 1983; 3 Rao (BIB14) 2002; 158 Ackerley (BIB20) 2003; 161 Shea, Yabe (BIB16) 2000; 1 Jacomy (BIB15) 1999; 73 Tu (BIB19) 1995; 129 Julien, Mushynski (BIB1) 1998; 61 Jung (BIB8) 2000; 47 Zhu (BIB13) 1998; 143 Willard, Simon (BIB7) 1983; 35 Grant, Pant (BIB2) 2000; 29 Nixon (BIB3) 1998; 10 Sanchez (10.1016/S0166-2236(03)00199-1_BIB18) 2000; 151 Jacomy (10.1016/S0166-2236(03)00199-1_BIB15) 1999; 73 Shea (10.1016/S0166-2236(03)00199-1_BIB17) 2001; 24 Ackerley (10.1016/S0166-2236(03)00199-1_BIB20) 2003; 161 Jung (10.1016/S0166-2236(03)00199-1_BIB11) 1999; 43 Collard (10.1016/S0166-2236(03)00199-1_BIB10) 1995; 375 Tu (10.1016/S0166-2236(03)00199-1_BIB19) 1995; 129 Zhu (10.1016/S0166-2236(03)00199-1_BIB13) 1998; 143 Nixon (10.1016/S0166-2236(03)00199-1_BIB3) 1998; 10 Rao (10.1016/S0166-2236(03)00199-1_BIB14) 2002; 158 Lewis (10.1016/S0166-2236(03)00199-1_BIB9) 1988; 107 Grant (10.1016/S0166-2236(03)00199-1_BIB2) 2000; 29 Julien (10.1016/S0166-2236(03)00199-1_BIB1) 1998; 61 Willard (10.1016/S0166-2236(03)00199-1_BIB7) 1983; 35 Pant (10.1016/S0166-2236(03)00199-1_BIB4) 1995; 73 Jung (10.1016/S0166-2236(03)00199-1_BIB6) 2000; 856 Hoffma (10.1016/S0166-2236(03)00199-1_BIB5) 1983; 3 Marzalek (10.1016/S0166-2236(03)00199-1_BIB12) 1996; 135 Shea (10.1016/S0166-2236(03)00199-1_BIB16) 2000; 1 Jung (10.1016/S0166-2236(03)00199-1_BIB8) 2000; 47 |
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| SubjectTerms | Amino Acid Sequence Animals Axonal Transport - drug effects Axonal Transport - physiology Biological and medical sciences Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Mice Neurofilament Proteins - drug effects Neurofilament Proteins - metabolism Neurology Neurons - drug effects Neurons - enzymology Phosphoric Monoester Hydrolases - drug effects Phosphorylation Protein Subunits - metabolism Sequence Deletion Vertebrates: nervous system and sense organs |
| Title | Does neurofilament phosphorylation regulate axonal transport? |
| URI | https://dx.doi.org/10.1016/S0166-2236(03)00199-1 https://www.ncbi.nlm.nih.gov/pubmed/12900166 https://www.proquest.com/docview/218747234 https://search.proquest.com/docview/73534467 |
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