Muscular Strength and Quality of Life in Older Adults: The Role of ACTN3 R577X Polymorphism

• Published in: International journal of environmental research and public health Vol. 18; no. 3; p. 1055
• Main Authors: Fernández-Araque, Ana, Giaquinta-Aranda, Andrea, Rodríguez-Díez, Jose Andrés, Carretero-Molinero, Silvia, López-López, Jorge, Verde, Zoraida
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25-01-2021; MDPI
• Subjects: Actinin - genetics; Activities of daily living; Adults; Age; Aged; Aging; Comorbidity; Female; Gender; Gene polymorphism; Genes; Genotype; Genotyping; Grip strength; Hand Strength; Humans; Male; Mortality; Muscle strength; Muscle Strength - genetics; Musculoskeletal system; Nutritional status; Older people; Patient admissions; Physical activity; Polymorphism; Polymorphism, Genetic; Population; Proteins; Public health; Quality of Life; Questionnaires; Regression analysis; Regression coefficients; Sarcopenia; Variance analysis; Womens health; United States > US; mobility; ACTN3; elderly population; multimorbidity; genetic variant; hand grip strength; quality of life
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph18031055

As longevity is increasing, the 65-year-old and older population is projected to increase in the next decades, as are the consequences of age-related muscle deterioration on the quality of life. The purpose of this study was to examine the associations of the
polymorphism with quality of life and muscular strength in an older Spanish population. In total, 281 older adults participated in this study. Anthropometric measurements, chronic diseases, prescribed medications, quality of life, hand grip strength, and physical activity and nutritional status data were collected.
genotyping was determined using Taqman probes. Multivariate regression analysis revealed in adjusted model that, in men, the
genotype was significantly associated with hand grip strength (HGS), regression coefficient (β) = 1.23,
= 0.008, dimension 1 of the five-dimension questionnaire EuroQoL (EQ-5D, mobility), (β) = -1.44,
= 0.006, and clinical group risk (CGR) category (β) = -1.38,
= 0.006. In women, a marginal association between the
genotype and the CGR category was observed, with a regression coefficient of (β) = -0.97, (
= 0.024). Our findings suggest that the
genotype may influence the decline in muscle strength and quality of life in older Spanish adult males.