Caco-2 cells permeability evaluation of nifuroxazide derivatives with potential activity against methicillin-resistant Staphylococcus aureus (MRSA)

Abstract Throughout the period of evaluation and selection in drug development, the assessment of the permeability potential of a compound to achieve an efficient refinement of the molecular structure has been widely appraised by the transport of substances across cell monolayers. This study aims to...

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Bibliographic Details
Published in:	Drug development and industrial pharmacy Vol. 41; no. 7; pp. 1066 - 1072
Main Authors:	B. Fernandes, Mariane, Gonçalves, José E., C. Tavares, Leoberto, Storpirtis, Sílvia
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare USA, Inc 01-07-2015 Informa Healthcare
Subjects:	5-Nitro-heterocyclic Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacokinetics Anti-Infective Agents - pharmacology anti-infectives biopharmacy Caco-2 Cells Chromatography, High Pressure Liquid drug development Humans Hydroxybenzoates - administration & dosage Hydroxybenzoates - pharmacokinetics Hydroxybenzoates - pharmacology intestinal absorption Methicillin-Resistant Staphylococcus aureus - drug effects Nitrofurans - administration & dosage Nitrofurans - pharmacokinetics Nitrofurans - pharmacology Permeability Solubility Spectrophotometry, Ultraviolet biopharmacy drug development 5-Nitro-heterocyclic intestinal absorption anti-infectives
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