Non-alcoholic fatty liver disease in patients with psoriasis: therapeutic implications

Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome - obesity,...

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Published in:Postȩpy dermatologii i alergologii Vol. 37; no. 4; pp. 468 - 474
Main Authors: Klujszo, Elzbieta H, Parcheta, Piotr, Witkowska, Anna B, Krecisz, Beata
Format: Journal Article
Language:English
Published: Poland Termedia Publishing House 01-01-2020
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Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome - obesity, lipid abnormalities, hypertension, and type 2 diabetes - significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks related to the liver, especially in patients with NAFLD.
AbstractList Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome – obesity, lipid abnormalities, hypertension, and type 2 diabetes – significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks related to the liver, especially in patients with NAFLD.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the West. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing the more severe form of the disease, with poorer outcomes. The components of the metabolic syndrome – obesity, lipid abnormalities, hypertension, and type 2 diabetes – significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks for the liver, especially in patients with NAFLD.
Author Klujszo, Elzbieta H
Krecisz, Beata
Witkowska, Anna B
Parcheta, Piotr
AuthorAffiliation 3 Faculty of Medicine and Health Science, Jan Kochanowski University, Kielce, Poland
2 Graduate of Medical University, Szeged, Hungary
1 Department of Dermatology, Regional Hospital, Kielce, Poland
AuthorAffiliation_xml – name: 1 Department of Dermatology, Regional Hospital, Kielce, Poland
– name: 3 Faculty of Medicine and Health Science, Jan Kochanowski University, Kielce, Poland
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  organization: Department of Dermatology, Regional Hospital, Kielce, Poland
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  givenname: Piotr
  surname: Parcheta
  fullname: Parcheta, Piotr
  organization: Department of Dermatology, Regional Hospital, Kielce, Poland
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  givenname: Anna B
  surname: Witkowska
  fullname: Witkowska, Anna B
  organization: Graduate of Medical University, Szeged, Hungary
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  givenname: Beata
  surname: Krecisz
  fullname: Krecisz, Beata
  organization: Faculty of Medicine and Health Science, Jan Kochanowski University, Kielce, Poland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32994765$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords methotrexate
biologic agents
liver disease
psoriasis
Language English
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Snippet Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD,...
Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the West. Psoriatic patients are at higher risk of having NAFLD, and at higher...
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StartPage 468
SubjectTerms Insulin resistance
Liver diseases
Metabolic syndrome
Psoriasis
Review Paper
Title Non-alcoholic fatty liver disease in patients with psoriasis: therapeutic implications
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