Non-alcoholic fatty liver disease in patients with psoriasis: therapeutic implications
Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome - obesity,...
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Published in: | Postȩpy dermatologii i alergologii Vol. 37; no. 4; pp. 468 - 474 |
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Abstract | Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome - obesity, lipid abnormalities, hypertension, and type 2 diabetes - significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks related to the liver, especially in patients with NAFLD. |
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AbstractList | Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing a more severe form of the disease with poorer outcomes. The components of the metabolic syndrome – obesity, lipid abnormalities, hypertension, and type 2 diabetes – significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks related to the liver, especially in patients with NAFLD. Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the West. Psoriatic patients are at higher risk of having NAFLD, and at higher risk of experiencing the more severe form of the disease, with poorer outcomes. The components of the metabolic syndrome – obesity, lipid abnormalities, hypertension, and type 2 diabetes – significantly correlate with NAFLD progression. The inflammatory state present in psoriasis plays a significant role in development of NAFLD and the metabolic syndrome. All patients with psoriasis and insulin resistance and risk factors for metabolic syndrome should also been screened for NAFLD, and planning of the treatment options should always take into consideration the possible risks for the liver, especially in patients with NAFLD. |
Author | Klujszo, Elzbieta H Krecisz, Beata Witkowska, Anna B Parcheta, Piotr |
AuthorAffiliation | 3 Faculty of Medicine and Health Science, Jan Kochanowski University, Kielce, Poland 2 Graduate of Medical University, Szeged, Hungary 1 Department of Dermatology, Regional Hospital, Kielce, Poland |
AuthorAffiliation_xml | – name: 1 Department of Dermatology, Regional Hospital, Kielce, Poland – name: 3 Faculty of Medicine and Health Science, Jan Kochanowski University, Kielce, Poland – name: 2 Graduate of Medical University, Szeged, Hungary |
Author_xml | – sequence: 1 givenname: Elzbieta H surname: Klujszo fullname: Klujszo, Elzbieta H organization: Department of Dermatology, Regional Hospital, Kielce, Poland – sequence: 2 givenname: Piotr surname: Parcheta fullname: Parcheta, Piotr organization: Department of Dermatology, Regional Hospital, Kielce, Poland – sequence: 3 givenname: Anna B surname: Witkowska fullname: Witkowska, Anna B organization: Graduate of Medical University, Szeged, Hungary – sequence: 4 givenname: Beata surname: Krecisz fullname: Krecisz, Beata organization: Faculty of Medicine and Health Science, Jan Kochanowski University, Kielce, Poland |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32994765$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Copyright | Copyright: © 2019 Termedia Sp. z o. o. 2019. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright: © 2019 Termedia Sp. z o. o. 2019 |
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Keywords | methotrexate biologic agents liver disease psoriasis |
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Snippet | Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the western countries. Psoriatic patients are at higher risk of having NAFLD,... Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology in the West. Psoriatic patients are at higher risk of having NAFLD, and at higher... |
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StartPage | 468 |
SubjectTerms | Insulin resistance Liver diseases Metabolic syndrome Psoriasis Review Paper |
Title | Non-alcoholic fatty liver disease in patients with psoriasis: therapeutic implications |
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