Activation of glucose transport by activatory receptor agonists of adenylate cyclase in rat adipocytes

1. Catecholamine, glucagon, and adrenocorticotropic hormone stimulated 2-deoxyglucose (2-DG) uptake via an increase in glucose transporters in plasma membranes, similarly to insulin. 2. In contrast to the action of insulin, the stimulating effects of these agonists on 2-DG uptake were abolished when...

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Bibliographic Details
Published in:	Comparative biochemistry and physiology. A, Comparative physiology Vol. 97; no. 1; p. 81
Main Authors:	Shirakura, S, Furugohri, T, Tokumitsu, Y
Format:	Journal Article
Language:	English
Published:	England 1990
Subjects:	Adenylyl Cyclases - metabolism Adipose Tissue - drug effects Adipose Tissue - metabolism Adrenocorticotropic Hormone - pharmacology Animals Biological Transport, Active Cholera Toxin - pharmacology Deoxyglucose - pharmacokinetics Epinephrine - pharmacology Glucagon - pharmacology In Vitro Techniques Insulin - pharmacology Male Monosaccharide Transport Proteins - drug effects Monosaccharide Transport Proteins - metabolism Rats Rats, Inbred Strains Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism
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Summary:	1. Catecholamine, glucagon, and adrenocorticotropic hormone stimulated 2-deoxyglucose (2-DG) uptake via an increase in glucose transporters in plasma membranes, similarly to insulin. 2. In contrast to the action of insulin, the stimulating effects of these agonists on 2-DG uptake were abolished when Gi was not activated. 3. The mode of the 2-DG uptake stimulation was partially different among these agonists.
ISSN:	0300-9629
DOI:	10.1016/0300-9629(90)90725-8