Oral leiomyosarcomas: report of two cases with immunohistochemical profile

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 104; no. 4; pp. e50 - e55
• Main Authors: Rodini, Camila Oliveira, DDS, MSc, Corrêa Pontes, Flávia Sirotheau, DDS, MSc, Rebelo Pontes, Hélder Antônio, DDS, MSc, da Silva Santos, Paulo Sérgio, DDS, MSc, Gallottini Magalhães, Marina, DDS, PhD, Santos Pinto, Décio, DDS, PhD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01-10-2007
• Subjects: Actins - analysis; Dentistry; Female; Gingival Neoplasms - chemistry; Gingival Neoplasms - pathology; Humans; Immunohistochemistry; Intermediate Filament Proteins - analysis; Leiomyosarcoma - chemistry; Leiomyosarcoma - pathology; Male; Maxillary Neoplasms - chemistry; Maxillary Neoplasms - pathology; Middle Aged; Surgery
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/j.tripleo.2007.05.005

Leiomyosarcoma of the oral cavity is a very rare tumor associated with aggressive clinical behavior and low survival. In this paper, we report 2 cases of leiomyosarcoma, affecting the gingival mucosa of a 54-year-old female and the maxillary bone of a 63-year-old male. Histologically, the tumors were composed of variably oriented fascicles of spindle-shaped cells with cigar-shaped nuclei and eosinophilic cytoplasm. The lesions were treated by surgical resection. Immunoreactivity to anti-vimentin, anti–smooth muscle actin, anti-desmin, anti-laminin, and anti–muscle-specific actin antibodies were found; conversely, the tumor cells were negative for anti-S100 and AE1/AE3 proteins. This report emphasizes the role of immunohistochemical study for correct diagnosis of leiomyosarcoma.