Human health screening level risk assessments of tertiary-butyl acetate (TBAC): Calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations

Abstract A screening level risk assessment has been performed for tertiary-butyl acetate (TBAC) examining its primary uses as a solvent in industrial and consumer products. Hazard quotients (HQ) were developed by merging TBAC animal toxicity and dose-response data with population-level, occupational...

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Bibliographic Details
Published in:	Critical reviews in toxicology Vol. 45; no. 2; pp. 142 - 171
Main Authors:	Bus, James S., Banton, Marcy I., Faber, Willem D., Kirman, Christopher R., McGregor, Douglas B., Pourreau, Daniel B.
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare USA, Inc 01-02-2015 Taylor & Francis
Subjects:	Acetates - pharmacokinetics Acetates - toxicity Animals Biotransformation chronic progressive nephropathy consumer product Disease Models, Animal Dose-Response Relationship, Drug Environmental Exposure - adverse effects Environmental Exposure - analysis genotoxicity Hazardous Substances - pharmacokinetics Hazardous Substances - toxicity Humans metabolism methyl tertiary butyl ether (MTBE) neurotoxicity Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - metabolism No-Observed-Adverse-Effect Level occupational Risk Assessment - methods screening level risk assessment solvent Tertiary-butanol (t-butanol) thyroid tier-based toxicity testing Toxicity Tests, Acute - methods Toxicity Tests, Chronic - methods α-2u-globulin chronic progressive nephropathy occupational α-2u-globulin consumer product genotoxicity methyl tertiary butyl ether (MTBE) tier-based toxicity testing neurotoxicity Tertiary-butanol (t-butanol) thyroid screening level risk assessment metabolism solvent
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