Tissue inhibitor of metalloproteinase 1 (TIMP-1) as a biomarker in gastric cancer: a review

• Published in: Scandinavian journal of gastroenterology Vol. 48; no. 8; pp. 899 - 905
• Main Authors: Grunnet, Mie, Mau-Sørensen, Morten, Brünner, Nils
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01-08-2013; Taylor & Francis
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - metabolism; Adenocarcinoma - mortality; Biomarkers, Tumor - metabolism; gastroduodenal-clinical; Humans; oncology-clinical; Prognosis; Stomach Neoplasms - diagnosis; Stomach Neoplasms - metabolism; Stomach Neoplasms - mortality; Survival Rate; Tissue Inhibitor of Metalloproteinase-1 - metabolism
• ISSN: 0036-5521; 1502-7708
• DOI: 10.3109/00365521.2013.812235

Abstract
Objective.
The value of Tissue Inhibitor of MetalloProteinase-1 (TIMP-1) as a biomarker in patients with gastric cancer (GC) is widely debated. The aim of this review is to evaluate available literature describing the association between levels of TIMP-1 in tumor tissue and/or blood and the prognosis of patients suffering from GC.
Material and methods.
Using the search words 'TIMP-1', 'Gastric Cancer' and 'Tumor marker', a search was carried out on PubMed. Exclusion criteria were articles never published in English, articles from before 1995 and articles evaluating tumor markers other than TIMP-1 in GC.
Results.
Of initially 50 articles, 17 were found to fulfill the selection criteria and relevant for this study. The 17 articles evaluated the usefulness of TIMP-1 levels in tumor tissue or blood, respectively, as a prognostic marker in patients with GC.
Conclusions:
A literature search showed that elevated protein levels of TIMP-1 in either tumor tissue extracts or in plasma from patients suffering from GC associates with poor patient outcome.