Anticancer potential of 3-hydroxypyridine-2-carboxaldehyde N(4)-methyl and pyrrolidinylthiosemicarbazones and their Zn(II) complexes in different cancers via targeting MAPK superfamily signaling pathway

Anticancer potential of 3-hydroxypyridine-2-carboxaldehyde N(4)-methyl and pyrrolidinylthiosemicarbazones and their Zn(II) complexes in different cancers via targeting MAPK superfamily signaling pathway

Schematic representation of mechanism of action of HHyPyPyrd on cancer cell proliferation. [Display omitted] Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and 3-hydroxy-2-formylpyridine N(4)-pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized and...

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Published in:Results in Chemistry Vol. 3; p. 100104
Main Authors: Shahi, Nerina, Pandey, Vivek, Pathak, Ankita, Thapa, Ram Sundar, Pokhrel, Prabina, Pokharel, Yuba Raj, Yadav, Paras Nath
Format: Journal Article
Language:English
Published: Elsevier B.V 01-01-2021
Elsevier
Subjects:
3-Hydroxypyridine
Anti-cancer activities
ESI-mass spectrometry
MAPK signaling pathway
Thiosemicarbazone
ZN(II) complexes
3-Hydroxypyridine
Anti-cancer activities
ESI-mass spectrometry
Thiosemicarbazone
ZN(II) complexes
MAPK signaling pathway
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Abstract Schematic representation of mechanism of action of HHyPyPyrd on cancer cell proliferation. [Display omitted] Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and 3-hydroxy-2-formylpyridine N(4)-pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized and characterized by elemental analysis, IR, UV–Vis, 1H NMR spectroscopy and mass spectrometry. These compounds were investigated for their antiproliferative potential against PC3 (Prostate Cancer), DU145 (Prostate Cancer), A549 (Lung Cancer), A431 (skin cancer) and Hela (Cervical Cancer cell) cell lines. All the compounds showed good antiproliferative activity against the tested cell lines. However, compound HHyPyPyrd showed remarkable antiproliferative activity against PC3 cell line with an IC50 of 0.69 µM. Cell death analysis by propidium iodide staining showed significant increase in cell death of PC3 cells in a concentration dependent manner. Furthermore, cell cycle analysis showed cell cycle arrest of PC3 cells at S phase. Our study shows that compound HHyPyPyrd induces the downregulation of JNK, c-Jun and Erk.
AbstractList Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and 3-hydroxy-2-formylpyridine N(4)-pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized and characterized by elemental analysis, IR, UV–Vis, 1H NMR spectroscopy and mass spectrometry. These compounds were investigated for their antiproliferative potential against PC3 (Prostate Cancer), DU145 (Prostate Cancer), A549 (Lung Cancer), A431 (skin cancer) and Hela (Cervical Cancer cell) cell lines. All the compounds showed good antiproliferative activity against the tested cell lines. However, compound HHyPyPyrd showed remarkable antiproliferative activity against PC3 cell line with an IC50 of 0.69 µM. Cell death analysis by propidium iodide staining showed significant increase in cell death of PC3 cells in a concentration dependent manner. Furthermore, cell cycle analysis showed cell cycle arrest of PC3 cells at S phase. Our study shows that compound HHyPyPyrd induces the downregulation of JNK, c-Jun and Erk.
Schematic representation of mechanism of action of HHyPyPyrd on cancer cell proliferation. [Display omitted] Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and 3-hydroxy-2-formylpyridine N(4)-pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized and characterized by elemental analysis, IR, UV–Vis, 1H NMR spectroscopy and mass spectrometry. These compounds were investigated for their antiproliferative potential against PC3 (Prostate Cancer), DU145 (Prostate Cancer), A549 (Lung Cancer), A431 (skin cancer) and Hela (Cervical Cancer cell) cell lines. All the compounds showed good antiproliferative activity against the tested cell lines. However, compound HHyPyPyrd showed remarkable antiproliferative activity against PC3 cell line with an IC50 of 0.69 µM. Cell death analysis by propidium iodide staining showed significant increase in cell death of PC3 cells in a concentration dependent manner. Furthermore, cell cycle analysis showed cell cycle arrest of PC3 cells at S phase. Our study shows that compound HHyPyPyrd induces the downregulation of JNK, c-Jun and Erk.
ArticleNumber 100104
Author Pokharel, Yuba Raj
Pandey, Vivek
Yadav, Paras Nath
Pokhrel, Prabina
Pathak, Ankita
Shahi, Nerina
Thapa, Ram Sundar
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Keywords 3-Hydroxypyridine
Anti-cancer activities
ESI-mass spectrometry
Thiosemicarbazone
ZN(II) complexes
MAPK signaling pathway
Language English
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Snippet Schematic representation of mechanism of action of HHyPyPyrd on cancer cell proliferation. [Display omitted] Zinc(II) complexes of 3-hydroxy-2-formylpyridine...
Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and 3-hydroxy-2-formylpyridine N(4)-pyrrolidinyl thiosemicarbazone (2)...
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Publisher
StartPage 100104
SubjectTerms 3-Hydroxypyridine
Anti-cancer activities
ESI-mass spectrometry
MAPK signaling pathway
Thiosemicarbazone
ZN(II) complexes
Title Anticancer potential of 3-hydroxypyridine-2-carboxaldehyde N(4)-methyl and pyrrolidinylthiosemicarbazones and their Zn(II) complexes in different cancers via targeting MAPK superfamily signaling pathway
URI https://dx.doi.org/10.1016/j.rechem.2021.100104
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